ANZCTR search results

This study is hybrid II effectiveness-implementation study with data collected in outpatient clinics at a specialist paediatric children’s hospital. The study will involve a pragmatic randomised controlled trial which will be conducted after the intervention is refined using interviews, underpinned by the Consolidated Framework for Implementation Research framework, and conducted with a sample of children with skin conditions. A mixed methods process evaluation and cost effectiveness analysis will be conducted. Children will be randomised to one of two intervention groups: completion of patient-reported outcome measures plus graphical displays of patient-reported outcome measure information provided to caregivers, older children and treating clinicians in consultations versus completion of PROMs without graphical display of the information in consultations (results will be provided at the end of the study). The primary outcome of the effectiveness trial will be overall health-related quality of life of children.

The purpose of this study is to trial a new method for rebuilding the tongue after cancer surgery Who is it for? You may be eligible for this study if you are aged 18 or over and have tongue cancer which requires at least half the tongue to be removed. Study details All participants in the study will undergo a reconstructive surgery where a piece of thigh muscle will be used to rebuild part of the tongue. This procedure takes place general anaesthesia during the same surgical procedure where the excision of the tongue cancer takes place, and the entire proceduretakes approximately 8-10 hours. As part of the study, all participants will have post-op assessments of tongue function and answer some questionnaires. It is hoped this study will help us better understand and standardize tongue reconstruction to improve speech and swallowing outcomes.

The study will involve patients who have a CMV or EBV infection requiring treatment following allogeneic blood or marrow transplantation. Patients with CMV or EBV requiring therapy will be randomly allocated to receive best available therapy or to best available therapy plus infusions of immune cells directed at CMV and EBV. The aim of the study is to assess whether the combination of best available therapy and immune cells improved the outcomes for patients.

This study will aim to explore men's reasons for transitioning from active surveillance to further treatment in prostate cancer management, and the factors which may have contributed to this decision. Who is it for? Men eligible for this study must be registered on the South Australian Prostate Cancer Clinic Outcomes Collaborative (SA-PCCOC) or the Prostate Cancer Outcomes Registry in Victoria (PCOR-VIC). Eligible men will have been diagnosed with prostate cancer from 2014 - 2019 and aged 75 or younger at diagnosis. In addition, you have previously consented to registry data collection and questionnaires. Study details All participants will be required to complete a one-time survey (sent via mail but may be completed on paper, online, or via telephone). This survey consists of questions relating to social-ecological factors (i.e., personal, social, community, organisation, policy) and your experience on active surveillance. It is hoped this research will provide further insight into the psychosocial factors that influence men to actively seek treatment prior to disease progression.

This is a pilot study of pain psychology therapy delivered by virtual reality to chest trauma patients admitted to hospital with acute pain. In this research study, VR software to deliver a suite of pain psychological therapies has been created. The suite contains three distinct modules; a pain education module, teaching the method of progressive muscle relaxation, and pain visualisation therapy. Patients will be provided the VR therapy as an adjunct to their existing acute pain management protocol of opioid medications and catheter-based local anaesthesia nerve block infusions. The primary objective of this prospective pilot study of 40 patients is to confirm feasibility, acceptability, and obtain initial effectiveness results on pain scores, opioid consumption, and pulmonary function.

This is a single-arm, uncontrolled feasibility and pilot study of a lifestyle weight management program for Duchenne muscular dystrophy (DMD). The aims of this study are to: * assess feasibility and acceptability of SNOW-P * determine the impact of SNOW-P on: weight, BMI, physical function, physical activity level, blood pressure, quality of life, fatigue, dietary intake and adverse events This study will recruit young people with DMD who have obesity. The expected outcomes for this study will be improved understanding of how to manage obesity in DMD and improved nutrition and wellbeing for young people after participating in a weight management program.

It is suggested that incomplete digestion of proline-rich proteins, including gluten, may be a cause of food intolerance and food allergies in some people, and lead to gut discomfort and distress. Foods containing these proline-rich proteins are widespread in our diet and are present in a broad range of foods. To improve the digestibility of the protein in these foods, Biohawk has developed a unique enzyme blend that can be added during food manufacturing. Anecdotal evidence suggests that bread made with gluten-rich flour treated with this enzyme blend is well tolerated by people who report having sensitivity to wheat-based products. However, independent testing is needed to confirm this, and to determine whether total protein and proline digestibility is improved. The main aim of this project is to evaluate the protein digestibility of bread products made from gluten-rich flour treated with an enzyme blend in healthy ileostomy participants.

The purpose of the proposed project is to examine the acceptability and efficacy of a low-intensity CBT-based self-management program, the Wellbeing Neuro Course to support the emotional wellbeing of adults with neurological disorders. The Course contains a 6-lesson 10-week internet delivered program. Participants will have brief weekly contact with a psychologist as they work through the Course. A two-group CONSORT-R Compliant randomised controlled trial (RCT) design will be employed, where participants are randomised to one of two groups: 1. Treatment Group (n = 100) 2. Waitlist Control Group (n = 100) Participants in the Active Treatment Group will receive full access to the Wellbeing Neuro Course. Participants are asked to complete standardised questionnaires at 4 main time points: Pre-treatment, mid-treatment, post-treatment, and 3-month follow-up. The Waitlist Control Group will receive the same treatment after the Active Treatment Group has completed the 10-week Course

This study aims to investigate whether a short period of coaching sessions, delivered in person with a clinician or via videocall, helps families of young children who have recently become aware that there may be a risk of autism spectrum disorder. We hypothesise that families need support and guidance in this period, and that these needs are not currently being met by health or disability services. is the researchers' hope that findings from this study will help families in limbo, waiting for diagnostic assessments and unsure what to do or how to help their child in the meantime. This may assist to minimise wasteful waiting periods in a child's early years, when intervention can be of great benefit to children, families and communities.

In this study we propose to investigate the effects of applying TMS using a novel individualised site targeting methodology with a behavioural outcome for the purpose of enhancing cognitive flexibility.