ANZCTR search results

The primary purpose of this study is to compare the differences between two daily disposable contact lenses over a period of 30 days. The study will compare the visual performance, lens comfort and handling between the two lenses. Given the similarity in their design, it is hypoethised that there will be minimal differences between the 2 lenses, in regards to vision, comfort and lens handling.

A transdiagnostic, cognitive behavioural and biopsychosocially-based digital health program for decreasing symptoms of anxiety and depression (called LIFE FLeX) will be evaluated in various treatment intensities. People who consent will be given access to the LIFE FLeX program immediately however if their symptoms of anxiety and depression do not improve within the first two to three weeks will be offered to have their treatment stepped-up and randomly allocated to one of two groups 1) LIFE FLeX program + allocation of a therapist for up to 10 minutes of weekly support conducted via video-chat technology and; 2) LIFE FLeX program + allocation of a therapist for up to 50 minutes of weekly support conducted via video-chat technology. LIFE FLeX is designed to assist people with their anxiety and depressive symptoms and contains six 'core' modules, plus an introduction module delivered over 8 weeks. There will also be a short 'Booster' Module released three weeks after the final module is completed. Each module will take approximately 25 minutes to complete. In addition, in order to reinforce the module-based information, there are 20-30 minutes of offline activities each week. Participants will also receive automated emails (e.g., to remind them to log on, when to complete post/follow-up questionnaires) and will be asked to self-monitor their mood and daily lifestyle events (e.g., sleep) and asked several questions at the beginning of each module, to monitor their progress. Participants will complete a pre-intervention assessment (Week 0), during intervention (Weeks 3, 6) assessments, post-intervention assessment (Week 9) and a 3-month follow-up assessment (Week 21). In addition, participants who withdraw from the study, or those who progress to a therapist condition will be invited to complete a semi-structured interview to explore their reasons around disengagement and experiences of the therapeutic alliance and effects of video-chat as a delivery method on the therapeutic alliance. Interviews will be conducted via telephone, instant messaging or video-chat. It is expected that people who have their treatment program (LIFE FLeX) augmented with a therapist will show greater reductions in anxiety and/or depressive symptoms at post-intervention assessment and follow-up assessment time points, as well as increases in positive affect and emotional regulation, in comparison to people in the maintenance of the 'no support' LIFE FLeX program.

We hypothesize that a significant percentage of patients with suspected or confirmed COVID-19 infection will require admission to the intensive care unit, mechanical ventilation and ECMO for refractory hypoxemia., In addition, it is hypothesized that a substantial proportion of patients will also present with concurrent coagulation disorders and thrombosis. Objectives: To describe clinical features; severity of pulmonary dysfunction; incidence of ICU admission and use of mechanical ventilation, coagulatory and thrombotic derangement, and ECMO technical characteristics; duration of ECMO; complications; and survival of patients with suspected or confirmed COVID-19.

Community rehabilitation after stroke may be limited due to factors as difficulties getting to appointments and limited access. Telerehabilitation, delivery of rehabilitation through communication technologies has emerged as a promising platform, and may overcome many of these difficulties. The primary aim of the pilot Randomized Controlled Trial (RCT) is to determine the effect of home-delivered telerehabilitation on physical activity compared with centre-based community rehabilitation in people with stroke with matched scheduled therapy time across both interventions. We hypothesize that people with stroke who receive home-delivered telerehabilitation will demonstrate 1) Increased daily physical activity and 2) better clinical, patient related and economic outcomes when compared with those receiving centre-based community rehabilitation.

This study is investigating the efficacy of chloroquine phosphate as a phophylactic against SARS-CoV-2 in health care workers at high risk of exposure.

We will investigate if exercise is effective in increasing muscle strength in people with Prader-Willi syndrome (PWS). We will conduct a phase II, multi-site, double-blind, randomised controlled trial with 6-month follow-up. Sixty participants with PWS aged 13 to 60 years will be randomised to receive one of two exercise programs. Participants will exercise twice a week for 24 weeks at their local gym supervised by an exercise health professional (usually a physiotherapist). We will measure muscle strength, muscle mass, functional strength, physical activity, community participation, and health-related quality of life at baseline (week 0), after the intervention (week 25) and 6 months later (week 52): We will recruit participants through PWS advocacy groups, specialist PWS clinics, and PWS registries and clinical databases.

Overactive sympathetic nervous system (SNS) signaling to major metabolic organs plays a pivotal role in the development & progression of Metabolic Syndrome (MetS) into several concurrent cardiometabolic disorders. Given the close relationship between the MetS & overactive SNS signaling, a minimally invasive treatment approach targeting inhibition of SNS to central metabolic organs (kidney & liver) is being proposed. The objective is to evaluate the safety of hepatic or renal artery denervation or a combination of both in a single intravascular procedure intended to improve one or more cardiometabolic parameters for hypertension (HTN) & glycaemic control. 45 patients with HTN with coexistent type-2 diabetes who qualify & consent, will be assigned to one of the 3 arms.

Zenker diverticulum is a herniation of the oesophageal mucosa resulting in pouch formation which can result in dysphagia and spontaneous regurgitation. Treatment with flexible endoscopic myotomy demonstrates lower morbidity compared to previous modalities. However, there is no established standard approach with unknown optimal technique. While the principal is to cut the cricopharyngeal muscle, a careful balance needs to be achieved to not cause perforation, while noting that an incomplete myotomy leads to higher recurrence rates. Intra-procedural measurement of distensibility across the Zenker's using the endoscopic Functional Lumen Imaging Probe (FLIP) could allow real-time determination of whether further incision will be required. Through retrospective review of medical records we hope to determine the feasibility of intra-procedural FLIP measurements in these patients, and assess whether there is a correlation between changes of distensibility following myotomy with symptoms and pouch size. We expect approximately 10 patients and hope to show that intra-procedural measurements will help to guide extent of myotomy to minimise risk of perforation as well as recurrence.

The purpose of this study is to determine if a multimodal (exercise, nutrition and nursings support) prehabilitation program for patient undergoing major gastrointestinal cancer surgery for curative intent can be built into routine care. Who is it for? Patients with stage I-III or limited stage IV colorectal or upper gastrointestinal cancer undergoing curative intent surgery at concord repatriation general hospital. Study Details The study will involve both an exercise and diet program 2-4 weeks prior to major gastrointestinal surgery. All participants will receive the intervention. 1.Exercise: The exercise component will involve supervised and tailored 60-minute group-based exercise sessions per week using a combination of resistance and aerobic exercises delivered by an accredited exercise physiologist. In addition, 3 x homebased exercise training. 2. Nutrition: The nutritional component will involve Oral high protein supplements (Fresubin® Protein Energy) containing 20g protein, recommended to be consumed daily within one-hour post exercise to capitalize on muscle synthesis (day one until two days prior to surgery). In addition, nutritional advice will be provided delivered by a dietitian to achieve adequate oral protein intake. 3.Nursing support: One (15-20 minute) nurse-led phone support session per week of intervention Assessment Involvement in the study will involve a variety of body measurements and questionnaires, including questions about quality of life and patient satisfaction. It is hoped this study will further insight into how prehabilitation can decrease length of stay, lead to better surgical outcomes, whilst evaluating the change in functional, nutritional and psychological status.

Fatigue is one of the most common and debilitating symptoms in patients on dialysis. The prevalence of fatigue ranges from 55% to as high as 97% in adult patients on dialysis and is associated with impaired quality of life and increased mortality. Fatigue is also consistently ranked as critically important by patient on dialysis, even higher than death. Our global Standardised Outcomes in Nephrology (SONG) initiative, involving over 2000 patients receiving dialysis, caregivers, and health professionals across 100 countries, established fatigue as a critically important core outcome. Lifestyle (including exercise) interventions was the top priority identified through the research priority setting partnership. Evidence for exercise interventions remains very uncertain due to factors such as the plethora of measurements used to assess fatigue and small sample size. A patient workshop was convened to identify and prioritise exercise interventions for the M-FIT study to ensure acceptability and feasibility. M-FIT is a multi-centre, adaptive randomised comparative effectiveness trial of three structured exercise programs and a control in patients receiving dialysis. The primary outcome of this trial is fatigue as measured by FACIT-Fatigue at 12 weeks. Secondary outcomes include additional measures of fatigue, quality of life, mood, life participation, body composition, exercise capacity, neuromuscular fitness, balance, physical activity, sleep, exercise adherence, SONG core outcomes, hospital admissions, cost-effectiveness, app usability, preference and safety.