ANZCTR search results

Older drivers have relatively high crash rates and are increasing in number. We aim to evaluate the relative effectiveness and cost-efficiency of interventions for older drivers. A randomised control trial comparing driving lessons, personalised feedback on driving skill, and a group based road-rules refresher course will be conducted. If effective, interventions will improve driving safety, reduce costs associated with crashes, and maintain social participation.

This is an international research project to test the primary hypothesis that jockeys and riders who have been trained in fall safety skills will have reduced injury severity in falls. Participants will be assigned to training intervention or control groups and those assigned to the training intervention groups will undertake an 8.5 hour skills-based fall safety training program. Following a data collection period, participants who are assigned to the control groups will be offered the same fall safety training program. The training is based upon modified gymnastics skills, and all training will be directly supervised by Lindsay Nylund who is a former Olympic gymnast with qualifications in physical education, vocational training, advanced accreditation in gymnastics coaching.

The purpose of this study is to test the safety and tolerability of a potential breast cancer treatment called endoxifen. Who is it for? You may be eligible for this study if you are a healthy female aged 18-65. [***Please note participants who have cancer are not eligible for this study.***] Study details Participants in this study will receive tablets, to be taken by mouth and will be randomised (by chance) to either the active drug or a placebo. Neither the participant nor investigators will know who gets the active or placebo drug. Initially, only a single tablet will be taken. After checking the results of this first day, participants continue into the second part of the study where they will take their assigned tablet once a day for another 14 days. As part of this study, all participants will need to provide blood samples, urine samples, answer questionnaires and have a physical exam.

Purpose / Hypothesis: This study seeks to determine the level of blood ketone in patients who fast for surgery. We also examine various risk factors which potentially lead to high ketone levels, and try to establish relationship between these factors and the presence of high ketone level. Methods: Participants will have two very small blood samples taken, one immediately before and one immediately after surgery. The relationship between the risk factors and the ketone levels is analysed to determine how strongly each factor affects the ketone level. By improving our understanding of ketone levels in patients fasting for surgery, this study will improve the clinical care we deliver by improving how we detect and treat patients who develop high ketone levels.

Older people living in residential care facilities (RACFs) are some of the most vulnerable in society with increasingly complex health and personal care needs. Transfers to Emergency Departments and hospitalization are common. The Aged Care Emergency Program was developed to better support acutely unwell residents in RACFs. It is a multi-component service level intervention designed to support RACF staff in identifying and addressing medical needs with an aim to reduce unnecessary hospital admissions. Using a stepped wedge non-randomised cluster design, a large scale evaluation was made of the roll out of the program across a broad geographic area of Hunter New England local health district.

This study compared brief intervals of stair climbing to moderate-intensity walking and physical activity guidelines for adults with metabolic syndrome.

This study examines the difference between implanting a conventional pacemaker and a novel technique in pacemaker implantation where the pacing lead is implanted in the His-bundle and deep septal region of the heart. This novel technique could circumvent the known adverse effects of conventional pacemakers, and result in improved patient outcomes. Conduction system pacemaker is hypothesised to result in improved cardiac function compared to conventional pacemakers.

Broken ribs are common and hurt. The pain from broken ribs can restrict breathing and may cause serious problems (for example lung infections) for some people. Two common techniques used for managing pain are the Paravertebral Block, and the Erector Spinae block. Both techniques can be effective, but it is not clear which technique is better or safer. This pragmatic study is looking to see if these techniques are the same or not, in terms of both benefits (e.g. relieving pain, improved lung function), and potential harms (e.g. collapsed lung, need for intensive care).

The aim of this study is to investigate whether a course of water based exercises, in addition to usual Physiotherapy, improves symptoms and quality of life in patients with Persistent Pelvic Pain due to endometriosis, when compared to usual Physiotherapy alone. If women in this study gain relief from their symptoms, hydrotherapy may become another treatment option for this condition. The results of this research will be used to decide whether hydrotherapy is useful to help treat this condition and whether it can be provided by the RBWH Physiotherapy Department.

This first in human study of LMR-123 will investigate the safety, tolerability and PK of single ascending doses of LMR-123 compared to placebo in healthy subjects.