ANZCTR search results

Returning to work after a stroke is an important rehabilitation milestone, and is associated with better physical and mental health outcomes. This study will pilot and evaluate feasibility of a return to work coordination service (known as RESET) that uses telecommunication to increase access to people who have had a stroke. The overall aim of this study is to test procedures and assessment measures that can be used in a full clinical trial of RESET, evaluating acceptability to participants, and satisfaction with the intervention.

Pulmonary Rehabilitation is recommended as a cost effective way of improving exercise capacity and quality of life for people with chronic obstructive pulmonary disease. In spite of the strong evidence for the effectiveness of pulmonary rehabilitation, many people are not referred and if they are referred they do not attend. We have developed and tested a series of three short patient education videos that address known barriers to patients attending pulmonary rehabilitation. These videos were piloted at Liverpool Hospital and we have subsequently been awarded funding from the Agency for Clinical Innovation to test their effectiveness. The aim of this multi-centre randomised controlled trial is to determine whether the use of the short videos delivered to people with chronic respiratory disease during a hospital admission increases the uptake of pulmonary rehabilitation.

This is a phase 1, single-center, randomized, double-blind, two-way crossover study comparing Abcertin and EU-sourced Cerezyme® in healthy volunteers between the ages of 18 and 45 years (inclusive). The purpose of this trial is to evaluate, characterize, and compare the pharmacokinetics, and short term safety and tolerability of single-dose intravenously administered Abcertin with EU sourced Cerezyme® in healthy volunteers.

The purpose of this study to enhance our understanding of the interactions between medications and the bacterial populations (which together comprise the microbiome) in the nose and sinuses. Our hypothesis is that both oral and topical steroids will differentially alter bacterial profiles in patients with CRS to influencing the clinical outcomes in patients. We will target patients in the pre-operative clinic presenting with symptoms consistent with a diagnosis of CRS. Patients who require medical management of their symptoms and consent to participate will be randomised to one of three groups, each of which consists of one of the standard treatment regimens for the pre-operative medical management of CRS (oral steroid or topical steroid or oral antibiotic).

The purpose of this study is to evaluate the effects of incorporating periodical rest periods within exercise sets to alleviate shortness of breath and improve psychosocial response to exercise in patients with advanced lung cancer. Who is it for? You may be eligible for this study if you are an adult who has advanced lung cancer ( stage IIIB-IV) Study details All participants in this study will receive 3 exercises targeting both the upper and lower body. Exercises will include leg press, seated row and chest press. There are two treatment conditions. One condition is the traditional set (TS) exercise, with no rests between repetitions. Participants will complete 10 repetitions in a row without rest. The other condition is the cluster set (CS) where participants will rest for 20 seconds after two repetitions until 10 repetitions are reached. Participants will complete 3 sets of exercise in both conditions and will wait at least 72 hours between the two conditions. Part of the study will involve questionnaires on shortness of breath and self confidence. It is hoped this study will identify a novel method of targeted exercise medicine that may alleviate shortness of breath and improve clinical outcomes in people with advanced lung cancer.

Heart failure is a common and serious problem in our community. It is unclear whether preventative treatment in people at high risk of heart failure, such as those with type 2 diabetes mellitus, works. Dapagliflozin is an anti-diabetic medication that has been shown to be effective in treating heart failure and reducing death. We are trying to determine whether using dapagliflozin in people with early features of heart failure prevents the progression of the condition.

The Risk Reduction for Dementia Initiative – North West (RReDI-NoW) will involve community members in 9 centres across northwest Tasmania to evaluate the Preventing Dementia massive open online course (PD MOOC) with or without additional community led dementia risk reduction initiatives. The effectiveness of the PD MOOC and community initiatives will be measured against providing written information about dementia risk reduction in a randomised controlled trial. The aims of the study are: • To examine the impact of the PD MOOC on dementia risk reduction knowledge, attitudes and behaviour, and risk states. • To examine whether engaging communities in dementia risk reduction initiatives has additional benefits above education through the MOOC alone. • To examine the sustainability of any improvements in dementia risk reduction knowledge, attitudes and behaviour, and risk states.

The main aim of the PAWalks study will be to examine the effectiveness of a technology-based dog-walking intervention for increasing daily physical activity (PA) of dog owners. The intervention is based on behaviour change theory and a commercially available wearable dog activity tracker (primary outcome: daily number of steps). The secondary objectives will be to examine if intervention-induced increases in PA are accompanied by improvements in sedentary behaviour (SB) and psychosocial health of owners (secondary outcomes: SB time, psychological distress, loneliness, positive affect, dog-ownership attributed social connections, dog-owner relationship), and frequency of canine behavioural problems.

Purpose of the study is to compare if orthopaedic patients with mild cognitive impairment who recieve computer based cognitive therapy have better changes in cognitive function, activities of daily living and overall rehabilitation outcomes when compared to patients receiving standard care. The secondary aim is evaluate the usability of computer based cognitive therapy for orthopedic patients in rehabilitation

In the 21st century there have been some significant advances in how we think about ‘health’ and about ‘family-centred services’. As a result, we are changing the ways we try to work with families to help them manage their children’s developmental disabilities. These ideas have been developed and ‘packaged’ – by a team of health services researchers, clinicians and parents – into a set of 5 weekly workshops for parents new to their journey as parents of children with long-term developmental disabilities. These workshops are collectively referred to as ENVISAGE: ENabling VISions And Growing Expectations. ENVISAGE aims to empower caregivers of children with disabilities to build self-efficacy, autonomy, and sense of competence; to increase their skills as parents of children with complicated lives; and to connect with other caregivers to improve parent and family outcomes. We hypothesize that the primary outcomes of ENVISAGE will be positive trends in the caregiver-reported outcomes of family empowerment and caregiver confidence.