ANZCTR search results

These search results are from the Australian New Zealand Clinical Trials Registry (ANZCTR).

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31167 results sorted by trial registration date.
  • Peer Tree: A smartphone application for young people (aged 16-25) with psychosis and other mental health conditions

    The aim of the research project is to deliver and test an innovative digital smartphone intervention, Peer Tree, which is designed to reduce loneliness in young people with psychosis and other mental health conditions. The intervention is administered daily for 6 weeks. Young people aged 16-25 years who report high levels of loneliness and have a diagnosis of a psychotic disorder or a different disorder that has psychotic features will be recruited. In accordance with a randomised control trial study design, after participants complete the baseline assessment, they will be randomised to either the treatment as usual or intervention group. Those in the waitlist group will complete treatment as usual but will be provided with the same content once they have completed the research project. This will be provided in the form of +Connect, the predecessor of Peer Tree that doesn’t not contain the forums. Our research is expected to contribute to the development of personalised, modular mental health interventions that are cost-effective and efficient. There are currently no personalised, modular interventions available to address loneliness in young people.

  • Exercise-therapy and education for knee osteoarthritis: comparison of telerehabilitation with face-to-face delivery

    This research project aims to determine the feasibility of completing a randomised controlled trial (RCT), to establish if tele-rehabilitation (exercise and education) is as effective as face-to-face delivery in people with knee osteoarthritis (OA). Osteoarthritis affects approximately 2.2 million Australians. People with OA are 2-3 times more likely to be out of work, report poor health, and have high psychological distress and severe pain. Knee OA is the most common presentation of OA and a National Health Priority. This study aims to determine the feasibility of completing a non-inferiority randomised controlled trial (RCT), to establish if telerehabilitation (exercise and education) is as effective as face-to-face delivery in people with knee osteoarthritis (OA).

  • Enhancing Treatment for Depressed Youth: A Randomised Trial of Adjunct Memory Specificity Training

    Current effects of treatment for depression in youth are modest. There is clear scope to enhance intervention in this critical period of early-onset depression. One way to do this is to target known cognitive vulnerabilities. This study will examine the effect of computerised memory specificity training (c-MeST) in addition to usual care, and test whether it enhances treatment effects and reduces risk of depression at follow-up. Youth aged 15-25 presenting to participating mental health service providers will be randomised to usual care + c-MeST or usual care. c-MeST involves completing a series of online modules providing personal memories with feedback to encourage more specific and detailed account of experiences. It is hypothesised that: • The c-MeST + usual care group will report significantly higher rates of remission of clinical and subclinical depression and lower severity of depressive symptoms at 1, 3, and 6 six-month follow-up, relative to a usual care group. • Improvements in memory specificity at 2 weeks will predict improvements in remission rates and severity of depressive symptoms at 1, 3 months and at 6 month follow-up. • The c-MeST + usual care group will report significant improvements on secondary outcomes of suicidal ideation, rumination, executive functioning, and problem-solving ability at 1, 3 months and six-month follow-up, relative to a usual care group.

  • Sleepwear fibre and sleep quality in menopausal women

    This study compares the sleep outcomes (sleep quality) between two different sleepwear type (closely matched for fabric thickness and weight) in peri- and post-menopausal women. It is hypothesised that sleepwearA provides beneficial measured sleep outcomes (sleep quality and quantity, and sleep encephalograph power density) over sleepwearB.

  • Study of RadianiX™ as a skin health supplement.

    This study aims to demonstrate the safety and effectiveness of a wafer containing glutathione (an anti-oxidant) as a therapeutic skin health supplement. The treatment involves taking glutathione wafer under the tongue 2 times daily for 12 weeks.

  • CardiacRehabPlus: Innovation to improve outcomes for TIA and cardiac rehabilitation patients

    Transient ischemic attack and minor stroke (TIA/mS) are common cerebrovascular events affecting tens of thousands of Australians. People with TIA/mS usually receive minimal, if any, rehabilitation despite high risk of further stroke, and in many, mild balance and gait problems. Also, people who have had a cardiac event are offered cardiac rehabilitation but do not necessarily have their balance assessed. This project addresses these two substantial gaps. People with TIA/mS will receive rehabilitation through existing cardiac rehabilitation services and the people with cardiac conditions who are participating in cardiac rehabilitation programs will be assessed for balance and gait dysfunction. If deficits are identified, balance and agility exercises will be provided.

  • Community Exercise for persons with multiple sclerosis

    This project will seek to identify 1) If a home based exercise programme which includes telephone/internet calls and an email newsletter to encourage compliance and long term adherence can be delivered by healthcare professionals to persons with mild to moderate MS living in rural Australia. 2) What is the best model of delivery by first establishing a 1:1 (1 healthcare professional to 1 person with MS) method, and next establishing a 1:group (1 healthcare professional to >2 person with MS) method. 3) The training requirements for healthcare professionals to deliver the program. 4) What are the effects of the exercise program on outcomes of physical activity, MS symptoms, and exercise adherence.

  • Modified forced expiration technique using expiratory resistance in adults with cystic fibrosis: A pilot study.

    The development of an effective airway clearance regimen is important to minimise development of irreversible airway obstruction in people with cystic fibrosis. Positive expiratory pressure (PEP) is often used as it helps to provide resistance during expiration, improve collateral ventilation and aid in the shearing of mucus from airways. The use of PEP and other expiratory resistive devices (ERD) as airway clearance techniques (ACT) in this population is well established in the literature but there is no literature which looks at the use of an ERD combined with masks during huffing, to improve sputum clearance. The proposed study will investigate the effect of using an ERD during a huff on ease of expectoration, sputum volume, and coughing, when compared to a huff without resistance. The hypothesis is that using an ERD during a huff will improve ease of expectoration, sputum volume and reduce amount of coughing required.

  • Feasibility of acupressure for post-operative nausea and vomiting

    Post-operative nausea and vomiting (PONV) occurs in 30-50% of patients, and can prolong the hospital stay. Acupressure can safely and effectively reduce the incidence of PONV by up to 30%. Over 80% of surgical patients would be willing to try acupressure for PONV, however this intervention has not been incorporated into routine peri-operative care. This study is embedded in a large project that aims to systematically examine the barriers and enablers in the implementation of acupressure for PONV, and to develop and implement strategies for successful application of acupressure. The specific aim of this feasibility study was to identify the suitable form(s) of acupressure to be used in a peri-operative setting. We used FAME approach to study its feasibility, appropriateness, meaningfulness and effectiveness and safety. Our initial FAME analysis of the existing literature indicates moderate to strong support to the feasibility of per-operative acupressure for preventing and treating PONV. The two forms of acupressure identified from the literature were wristband and auricular acupressure. In this study, we trialled out these two forms of acupressure and to identify if, when and how acupressure could be implemented. We hypothesised that this simple, non-drug intervention would be well-accepted by patients and staff, and with modification could be integrated into the per-operative setting without any difficulties. Acupressure could reduce PONV incidents and / or medication use. Data from the study also helped us identify barriers and enablers for later implementation. This study was conducted among patients undergoing elective surgery at Northern Hospital.

  • Use of cadaveric donor blood in liver transplant.

    Liver transplant (LT) can be associated with large volume blood loss and subsequent transfusion. Allogenic transfusion of bank blood (BB) has been associated with increased morbidity and mortality. In addition BB has increased cost implications. In our center cadaveric donor blood (DB) is collected in all instate recipients who are ABO and CMV compatible. Briefly DB is collected by inserting a 32Fr chest drain into the inferior vena cava and draining under suction into a cell saver reservoir prior to aortic cross clamping. Following a full cross match the DB is then processed by the cell saver and transfused into the recipient in preference to BB. A retrospective review of transfusion requirements for all patients undergoing LT was conducted to see the effects of DB on transfusion requirements in LT.

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