ANZCTR search results

The purpose of this study is to examine the effects of a brief 2-hour Compassionate Mind Training intervention on self-compassion levels of parents of autistic children from 3 to 17 years of age. The intervention incorporates physical and mental skills that cultivate compassion, such as grounding, rhythmic breathing, mindfulness, and developing more compassionate ways of relating to the self and others. It is predicted that parents in the treatment group will report higher levels of self-compassion, better mental well-being and emotion regulation, and fewer negative emotions.

Adult survivors of child sexual abuse and other gendered violence are at heighten risk of both mental and physical health conditions. We seek to evaluate a peer-led program, Left Write Hook, which incorporates boxing and expressive writing, to empower survivors. This Type II Hybrid effectiveness-implementation randomised control trial aims to (1) evaluate effects of Left Write Hook in improving self-efficacy (primary effectiveness outcome), and subsequently, modifiable indicators for chronic disease (secondary effectiveness outcomes), in adult survivors of child sexual abuse and other gendered/family violence, and to (2) determine the fidelity of the train-the-champion implementation strategy for intervention training and delivery (primary implementation outcome). Compared to boxing-only, we expect Left Write Hook to meaningfully improve both mental and physical health outcomes.

Title: The Impact of an interprofessional exercise program on improving glycaemic management in children and adolescents with type 1 diabetes Short Title: T1DM & Exercise Study Sites: Tweed Valley hospital SCU gymnasium, Bilinga NSW 4225 Study Aims/Objectives/Hypothesis: The aim of this research is to answer the following two research questions. 1. Does participation in an interprofessional exercise program reduce the incidence of exercise induced hypoglycaemia and nocturnal hypoglycaemia? 2. Does participation in an interprofessional exercise program, improve the confidence of individuals and families to manage T1DM? Study Design: Pre/post intervention trial Study Outcome Measures: Problem Areas In Diabetes (PAID) (Welch, 1997) Diabetes Distress Scale (DSS) (Fenwick, 2018) Physical Activity Questionnaire for Children and Young People (Kowalski, 2004) Incidence of exercise induced hypo/hyperglycaemia Nocturnal hypoglycaemia. Study Population: children and young people between the age of 12 to 18 with T1DM, who are current clients of our Paediatric and Young Adult Diabetes Outpatient clinics Number of participants: Due to the focus of this study, recruitment will target 12- to 18-year-olds, who attend the Tweed hospital for management of T1DM. We currently see 70 children/young people for T1DM management. On average, over the last two years, 10 children/young people are new to the service each year. We estimate a convenient sample size of approximately 20 to 25 participants from our paediatric and young person’s diabetes service will be eligible to participate. Translation to Clinical Practice: Development of protocol for exercise physiologists to support children and young people with T1DM to maintain physical activity through the life span. Key Ethical and Safety Considerations: Management of hypo/hyperglycaemia, trips/slips and falls and developing their confidence in maintaining lifelong exercise. Working with children and young people and ensuring that consent is informed and appropriate based on age.

Follicular lymphoma (FL) is a common type of slow-growing blood cancer. In Australia, the standard treatment for FL is a combination of drugs and immunotherapy. However, this treatment can have side effects, and the cancer can come back without clear options for further treatment. Researchers are now focusing on finding better options to treat FL with fewer side effects and better outcomes for patients. Who is it for? You may be eligible for this study if you are aged 18 and have been diagnosed with follicular lymphoma. Study details LS25 will operate as a sub-study of an AbbVie-sponsored clinical trial called EPCORE-FL2, with the aim to closely monitor how the immune system responds to treatment for FL over time. EPCORE-FL2 patients can choose to participate in LS25, where they will provide extra blood samples, biopsy sample and collect gastrointestinal microbiota sampling. These samples will help researchers understand how the immune system is working inside the tumor and in the bloodstream during treatment. The hope is that by studying these samples, treatments can be tailored more effectively for people with FL, potentially leading to better outcomes.

Schools have been an ideal setting for intervention studies to take place. In PE settings, interventions targeting the psychomotor domain have been the most dominant. With amendments to educational policy, a gap has emerged where interventions targeting ‘other’ outcomes has promoted research into the cognitive, affective and social domains. This intervention study is aimed at evaluating the effect of social domains on high school students. This will be done through the Teaching Personal and Social Responsibility framework, developed by Don Hellison which was initially designed to re-engage students from low socio-economic status backgrounds in PE classes. Whilst TPSR studies have been scattered throughout the world with positive outcomes (academic and otherwise). TPSR has not yet been featured in high schools in Australia.

To date, Moderated Online Social Therapy (MOST) has only been trialled in clinical research settings with referrals from clinical services. The Evaluating the Impact of a Digital Youth Mental Health Service study: A pragmatic randomised controlled trial of a digital mental health service for youth with anxiety and depression (EVOLVE), seeks to extend upon previous feasibility, acceptability, and efficacy research in these settings by testing the effectiveness and cost-effectiveness of MOST in a real-world, community sample. Evolve is a prospective, parallel two-group, CONSORT-R compliant, superiority RCT. Young people in the general community aged 15-25 years, with self-reported anxiety and depression symptoms, will be recruited through a targeted social media campaign.

A 2 year clinical study to compare the clinical results of a new design to existing designs, of an acetabular hip cup aimed to resist dislocation while allowing normal motion, after total hip replacement surgery for patients 50 and over suffering a fracture of the neck of the femur. The study hypothesis is that at a minimum of 2 years, the new design is at least as safe and effective as existing standard total hip cups used to treat femoral neck fractures, and the new design reduces the risk of revision for dislocation in the first year versus those standard cups.

Pre-operative fasting is an important part of preparing for anaesthesia. Fasting reduces the volume and acidity of the stomach contents, which serves to reduce the risk of regurgitation and pulmonary aspiration. Fasting can be particularly stressful for young children, which can in turn lead to negative psychosocial and physiological outcomes. In this study, we wish to investigate if a pre-procedural carbohydrate-based chewables can help children to better tolerate pre-operative fasting.

Pre-operative fasting is an important part of preparing for anaesthesia. Fasting reduces the volume andacidity of the stomach contents, which serves to reduce the risk of regurgitation and pulmonary aspiration. Fasting can be particularly stressful for young children, which can in turn lead to negative psychosocial and physiological outcomes. In this study, we wish to investigate if a pre-procedural carbohydrate-based chewables can help children to reduce the negative effects of pre-operative fasting. We hope to provide evidence that these chewables are able to help kids tolerate fasting by improving their fasting discomfort, and reduce their post-operative nausea and vomitting.

This research study tests whether people, who are feeling unwell with an influenza-like illness, find swabbing themselves at home to be an acceptable method of detecting influenza and other viruses. Patients experiencing cough, fever, and fatigue will be provided with a home-swab kit by their GPs. After they swab themselves at home, patients will return the swab by post to the pathology provider, and answer survey questions about their experience.