ANZCTR search results

The primary purpose of this study was to evaluate the current practice at a single inflammatory bowel (IBD) tertiary referral center, in order to identify the optimal surgical and medical management of the rectal stump after an subtotal colectomy for severe colitis. We hypothesize that an extra-fascial management of the rectal stump will have lower complication rates compared to an in-situ management of the rectal stump.

Headache is a common reason for presentation to emergency departments (ED). Headache presentations have been shown to comprise 1.35% (95%CI 1.34-1.36%) of total public hospital ED presentations across Queensland. There are a wide range of possible causes including primary headache (benign headache), migraine, trigeminal neuralgia, tumours, ntracranial haemorrhage, meningitis/ encephalitis/ cerebral abscess, toxicities and cerebrovascular events. This study will provide aninter-regional and international perspective on the epidemiology of non-trauma-related headache, its investigation, treatment and outcome.

The colpotomiser is a key instrument utilised at laparoscopic hysterectomy. In the Western Sydney Local Health District (WSLHD), the Rumi II® [Cooper Surgical] and the Biswas [Storz] are two commonly used uterine manipulators during laparoscopic hysterectomy. Both of these devices are FDA approved and already in general use. Currently, there are multiple published articles evaluating the effectiveness of individual colpotomisers at hysterectomy, however there are few randomised controlled trials comparing devices, and none comparing Rumi II and Biswas. The study aims to recruit 96 patients over a 12 month period. The primary outcome is operative time. Secondary outcomes include standard peri-operative measures including blood loss, blood transfusion, complications, readmission, return to theatre, and conversion to an alternative colpotomiser device. A subjective surgeon assessment using a Likert scale will assess the ease of insertion, manipulation, surgical access and maintenance of pneumoperitoneum.

The purpose of this project is to provide evidence for an alternative administration method for short term continuous intravenous (IV) antibiotic infusion in patient with only peripherally inserted venous cannula (PIVC) access. The evidence may allow our Hospital In The Home (HITH) to broaden service provision locally but will ultimately provide evidence for those HITH services considering to expand infusion modality, or to those previously relying on anecdotal and observational evidence. It is hypothesised that a Baxter LV10 elastomeric infusor paired with a PIVC when compared to a CADD-solis 2120 programmable pump will deliver at least 90% of the intravenous antibiotic volume after at least 22 of the 24 hours of continuous infusion.

The purpose of this study is to determine if new imaging technologies are a valid and accurate method of detecting lymph node metastases. Who is it for? You may be eligible for this study if you are an adult who has been diagnosed with prostate cancer. Study details All participants will have 2 specialised imaging scans (68Ga-PSMA PET and nano-MRL) prior to a prostatectomy and lymph node dissection. It is hoped that this research will help determine if these two imaging tests are useful in providing accurate but non-invasive methods of diagnosing metastatic prostate cancer. Thus guiding better targeted treatment.

The primary purpose of this study is to investigate the effects a brief, one-off writing exercise can have on the psychological outcomes of individuals living with a stoma. The study design is a mixed analysis of variances (MANOVA) comparing 2 groups (intervention and control condition) across 3 time points (baseline, one week and one month following the writing exercise). It is hypothesised that those in the intervention condition will see statistically significant improvements in a range of psychological outcomes, and more so in comparison to those in the control condition.

This is a nationwide study funded by the National Health and Medical Research Council that will determine the clinical efficacy, cost -effectiveness and patient acceptability of a new treatment for children who have anxiety disorders. For many children and their parents, anxiety can be highly disruptive and prevent children from doing things that other children their age can do. Participants will be 380 anxious children aged 7 - 12 years. This project will examine two computer-delivered treatment conditions and determine if they are as effective as each other in alleviating children’s anxiety disorders. Children will be randomly assigned into one of two treatment conditions that are delivered via computer at home. One treatment condition is called positive search training (PST), this will take 30 minutes to complete, 4 times a week over 3 weeks on a computer, laptop or tablet. Children view a wide variety of pictures and learn to focus their attention on the positive and calm pictures among them. PST also includes verbalisations, catch phrases and interactive games. The second treatment program is called cognitive behavioural training (CBT). Children complete 10 sessions (one per week) over 10 weeks and parents complete 6 sessions over 10 weeks, on a computer, laptop or tablet. The sessions are 20 - 60 minutes in duration, and include a variety of interactive games, quizzes and animations. Both treatment conditions are accompanied with instructions and phone calls to assist with setting up the treatment at home and children's progress will be monitored by therapists and project staff throughout the duration of treatment. The following hypotheses will be examined: (a) Primary clinical outcome: PST will produce significantly greater reductions on the primary outcome measure of clinician rated diagnostic anxiety severity by the post-PST end-point compared to computer-delivered CBT. By the primary 6-month end-point, PST will be non-inferior to CBT. Between the post-PST and 6-month end-points, diagnostic severity will remain low in children who received PST and decline in children who received CBT, such that any differences between PST and CBT will be clinically unimportant at the 6-month end-point and the 12-month follow-up. Also examined will be cost effectiveness and patient acceptability. PST will be associated with lower treatment costs and greater child and parent acceptability

Caregivers’ own attachment experiences are integral in predicting their child’s formation of secure attachment relationships, which are fundamental to healthy psychological development. As such, parents’ disrupted early attachment experiences may lead to parallel disruption in their child’s attachment experiences, increasing vulnerability to emotional and behavioural problems during development and later in life. Thus, the current study aims to reduce emotional and behavoural problems in children by targeting underlying processes relating to caregivers’ own attachment experiences and resulting behaviours. As such, a randomised, parallel-groups, controlled trial will be conducted to evaluate the efficacy of a newly-developed, six-week attachment-based family intervention compared to treatment as usual. Participants will include the families of children aged 6-12 experiencing either emotional or behavioural difficulties. Other outcome variables that will be explored include parents’ reflective functioning, parental mental health and helplessness, and overall family functioning.

To determine the association between patient serum vitamin d status and clinical IVF outcomes such as clinical pregnancy and live births arising from fresh embryos transferred. Our hypothesis is that those with a sufficient vitamin d status (> 50 nmol/L) will have more favourable outcomes in comparison to those with insufficient levels (< 50 nmol/L). We will examine vitamin d status as a continuous and as categorical variables while adjusting for various other infertility parameters including patient age and ovarian reserve.

The aim of this study is to define what is a normal blood glucose level post meal in people without diabetes. This study involves consuming five standardised test meals of varying macronutrient composition over five days. To assess the effect of each meal on post-meal blood glucose participant glucose levels will be measured continuously for 4 hours post- meal.