ANZCTR search results

A clinical research study to evaluate focal balloon contouring to determine whether it is safe and may be effective in reducing the appearance of moderate or severe cellulite on the thighs and buttocks.

The purpose of this study is to assess the feasibility of an education and exercise program called Co-PreP in the context of prostate cancer. Who is it for? You may be eligible for this study if you are aged 18 or over are independently mobile and are receiving treatment for prostate cancer. Study details All participants in this study will attend a weekly outpatient group program prior to commencement of their treatment. The first session will include an hour of group exercise and an hour of education delivered by a nurse and physiotherapist. Subsequent sessions will include an hour of group exercise until commencement of treatment. Participants will complete a number of questionnaires before and after the program. It is hoped this research will demonstrate the feasibility of the Co-PreP program and contribute to improved physical function and decreased rates of anxiety and depression during and after commencement of cancer treatment.

Australia relies on volunteers to fulfil its blood donation requirements. The number of potential donors is constrained by strict donor eligibility criteria necessarily imposed to ensure the safety of the donor and of the blood supply. Not all volunteers who present to donate have veins which are easy to see and feel. Recent findings from the VALIANT Trial using independent assessment of donor vein suitability for successful phlebotomy found that only 50% of donors were assessed as having easily visible and palpable veins; the phlebotomy success rate in these donors was 98% (P. Mondy MD, et al unpublished data August 2018). However, 12% of donors were assessed as having veins which were difficult to see and to feel, and 25% of donors in this group experienced a failed phlebotomy. In donors with intermediate vein visibility and palpability scores, the phlebotomy success rate was 92% (P. Mondy MD, et al unpublished data August 2018). Recent knowledge exchanges with international blood operators have identified that significant improvement in phlebotomy success rates can be achieved with the use of a skin marking device to assist phlebotomists locate the position and direction of veins after the skin disinfection has occurred, when re-palpation is not possible. The use of permanent markers to identify the site of surgery / invasive procedures is standard practice in most clinical settings and forms part of the surgical safety procedures both locally and internationally. To date there is no published data on the use of surgical skin markers in a blood donation setting. The following study proposes to determine if a single use sterile skin marker used to indicate the location and direction of a preferred vein prior to venepuncture increases the rate of phlebotomy success. A single use sterile skin marker will be used for the trial in order to minimise any source of nosocomial infection transmission between donors.

The rising acuity and complexity of hospital care has increased the need for patient surveillance while also posing obstacles to this practice in general wards. Nursing assessment practices are narrow, focused on vital signs and concentrated at the pointy end of actual patient deterioration: a stage at which effective and preventative nursing intervention is not relevant and medical rescue is the model of care. This three year single blind, cluster-randomised controlled trial will be implemented across seven hospitals. It will test an enhanced model of nurse surveillance, supported by systems-level practice change, redirecting practice from rescue to prevention of patient deterioration in general wards. The project provides the first rigorous evaluation of strengthening nurse surveillance to improve patient and organisational outcomes, including studies of clinical and cost effectiveness.

The purpose of this trial is to assess the effect of lens design on contact lens dissatisfaction in symptomatic, pre-presbyopic, CL wearers with a binocular vision disorder and / or contact lens discomfort.

The project aims to characterise airway collapse in obstructive sleep apnoea (OSA) by utilising a multimodal catheter during a sleep study normally used for OSA diagnosis. Traditionally diagnosis would not readily identify the reason for obstruction and current methods of simulating airway collapse are often not comparable to that of natural sleep. This study aims to increase our understanding of the mechanisms of airway collapse during natural sleep of OSA patients with a view to improved targeting of subsequent therapeutic interventions. It is considered that a simple method to establish the primary site and mechanism for upper airway collapse during naturally occurring sleep would improve the ability of clinicians to distinguish which patients would benefit from a variety of treatments available. By introducing a newly developed manometry catheter into sleep studies of 15 known OSA sufferers we expect to be able to determine the location of the site(s) of collapse, the degree of occlusion that occurs, the severity of reduced air flow, the anatomical features associated with and mechanism of collapse. The device has the ability to record pressure, temperature, contact force and visualisation of the point of collapse.

PURPOSE OF STUDY To establish the outcomes of patients with finger flexor tendon repairs managed with an early active motion program at the Royal Adelaide Hospital (RAH). The specific aims of the study are to: • Gather baseline information for patients with isolated finger flexor tendon repairs. • Establish inter-rater reliability in assessment methods used to enable more than one rater to be involved. • Collect outcome measures for patients managed with an early active motion program for a period of 3 months.

This research study aims to explore intra-individual variability in symptoms over time and intra-individual predictors of symptom severity. A series of n-of-1 observational studies with individuals with ME/CFS will be conducted. The study also aims to assess the acceptability and feasibility of participating in n-of-1 observational studies from the perspective of individuals with ME/CFS. This will be achieved by conducting semi-structured interviews with participants at the end of the study and by examining participant adherence to study procedures (e.g. questionnaire completion rates).

This study aims to compare the visual performance of NaturalVue Multifocal contact lenses with prototype multifocal contact lenses. Participants will wear each lens type in both eyes for a minimum of 7 days. After this period, vision and subjective ratings with each lens type will be assessed.

Otitis Externa (swimmers ear) is inflammation of the ear canal and leads to significant pain. The current treatment involves ear drops which are difficult to insert and requiring regular insertion. This leads to decreased patient compliance and a notably increasing level of antimicrobial resistance. This project involves the initial assessment of a newly created thermoresponsive ear gel (a gel that is drops at room temperature and changes to a gel a body temperature) in individuals with otitis externa. We hypothesis the ear gel will gelate in the ear canal, treating otitis externa and causing minimal adverse events.