ANZCTR search results

The aim of this research is to see whether a self-guided online mindfulness intervention leads to an increase in mindfulness and reductions in anxiety/depressive and stress symptoms in parents of children with DD. Based on previous research involving online mindfulness interventions with the general population, we expect that parents of children with DD will experience increases in mindfulness and reductions in anxiety, depressive and stress symptoms as a result of the intervention. If this intervention leads to increases in mindfulness and reductions in symptoms of distress, and parents rate the intervention as acceptable, then these preliminary results would suggest e-treatment as a possible alternative to current face-to-face treatments.

In this single-centre study, two groups of women who were normal weight prior to a recent pregnancy will be recruited at 12 months post-partum: women who have already returned to their pre-pregnancy weight (group A) and those who remain 10% or more above their pre-pregnancy weight (group B). Women in group B will be prescribed a hypocaloric diet until they return to their pre-pregnancy weight. Hormones involved in appetite regulation and DNA methylation state in peripheral blood mononuclear cells in weight-relevant genes will be compared between groups. We hypothesise that in women who remain 10% or more above their pre-pregnancy weight 12 months post-partum (group B), the elevated weight is ‘defended’, and that compensatory changes in hormones involved in appetite regulation will occur when they lose weight.

The purpose of this study is to evaluate two different recall methods for cervical screening and mammography in Aboriginal women. Who is it for? Women aged between 25 and 74 who attend the Illawarra AMS and who are due for routine cervical screening and breast cancer screening, are eligible for involvement in this study. Study details Participants in this study will be randomised (by chance) into two groups. One group will receive a phone call reminding them that they are due for screening and encouraging them to make an appointment for screening, followed by two reminder SMS's if they do not respond. The second group will receive a recall letter reminding them that they are due for screening and encouraging them to make an appointment for screening, followed by two further reminder letters if they do not respond. We will measure whether women attend for cervical screening, and whether they make an appointment for screening. We also will measure relative costs of each intervention. It is hoped this research will provide evidence as to which recall method is most successful and cost-effective for cervical screening and mammography.

This study will look at the feasibility of using acoustic tools in the home environment to improve patient experience with CPAP therapy.

The clinical outcome of arthroscopic rotator cuff repair including pain and ROM is generally favourable Despite advances in surgical techniques for rotator cuff repair, postoperative non-healing of rotator cuff tendons (tendon re-tear) is a serious issue, with an incidence ranging between 20% and 95%. Given that re-tear rate after cuff repair is a serious issue, a number of approaches have been investigated to improve rotator cuff repair healing including advancements in the fields of repair materials, repair techniques, biological augmentation and rehabilitation protocols. In this study we examine the healing effect of HA after cuff repair taking in consideration that some in-vitro and animal studies have demonstrated a significant positive effect of HA on tendon healing. Moreover, the efficacy and safety of HA in some abdominal surgeries and as a non-surgical therapy in shoulder disorders has been widely reported.

CRN00808 is being developed for the treatment of acromegaly. This four-way crossover single dose study will compare the pharmacokinetic and safety profiles of CRN00808 over four periods under the following dosing conditions; Condition A: Subjects will remain fasting for 4 hours after drug administration. Condition B: Subjects will remain fasting for 2 hours after drug administration. Condition C: Subjects will remain fasting for 1 hour after drug administration. Condition D: Subjects will receive a standard dinner then fast for 2 hours prior to drug administration. After dosing, the subject will fast overnight.

NeedleCalm is a single-use disposable medical device to alleviate pain associated with injections and assist with the reduction of fear of injections. The NeedleCalm™ technology uses the gate control theory of pain awareness and transmission.The device will be intended for use for all blood collections, intravenous cannula insertion, IM and SC injections.

Low blood pressure is a common problem in critically ill patients. It is often associated with compromised organ blood flow, leading to organ dysfunction. Administration of fluids into a vein is a common method to treat low blood pressure, which aims to increase blood volume to improve organ blood flow. The effect of fluid temperature on blood pressure and cardiac output is largely unknown. In healthy volunteers, it was found that room temperature fluids led to a bigger increase in blood pressure than warmed fluids, but caused a decrease in cardiac output. This was thought to be due to reflexive constriction of blood vessels in response to cold. A decrease in cardiac output may in turn cause lowered organ blood flow. This study aims to compare the effect of room temperature and warmed fluid therapy on cardiac output and blood pressure, in critically ill patients. We postulate warmed fluids may lead to better increase in cardiac output, compared to room temperature fluids. If this is true, warmed fluid therapy may become standard to improve organ blood flow in critically ill patients.

Children with respiratory illness including CF and non CF bronchiectasis are the largest cohort of children requiring PICCs at Queensland Children's Hospital (QCH). Traditionally PICCs require a general anaesthesia to establish procedural compliance. Midlines are also used internationally to administer intravenous antibiotics without necessitating general anaesthesia. We hypothesise that the need for GA will be reduced in this patient cohort whilst still providing the necessary treatment. This will benefit this patient population and the healthcare institution through reduced procedural risk and corresponding respiratory compromise, as well as reduced costs associated with theatre personnel. . The primary aims of this research is 1) to evaluate the feasibility of launching a full-scale efficacy trial, using pre-defined feasibility criteria for recruitment, retention and protocol fidelity and 2) need for general anaesthetic.

The research project will aim to establish the utility and acceptability of the GroWell for Health Program, a novel self-directed eight week eHealth multiple health behaviour change intervention tailored for midlife adults. The research design is a pre-test, post-test trial and will be conducted with 60 men and women aged 40 to 59 years without any existing diagnosis of cardiovascular disease, type 2 diabetes or cancer in the past 12 months. Each participants will be allocated to either Intervention Group A (Program independent) or Intervention Group B (Program + virtual nurse coaching), where the intervention will be delivered accordingly. Baseline (0 weeks), post-intervention (8 weeks) and follow-up (16 weeks) data will be collected from all participants via an online survey and a virtual appointment. Participants in Intervention Group A will also partake in a short qualitative semi-structured questionnaire to provide feedback about the program delivery.