ANZCTR search results

This study aims to test the effectiveness of cognitive behaviour therapy in combination with light therapy compared to relaxation audio. Who is it for? You may be eligible for this study if you are a woman aged over 18, have a diagnosis of primary breast cancer (any stage) and are receiving (or will receive) chemotherapy. Study details Participants will be randomised (by chance) to one of two treatments. One treatment (the Intervention group) is a cognitive behavioural therapy session in addition to use of Light glasses to be worn for 30 minutes each morning. The other group (the Control group) will receive relaxing audio tracks by email. The Control group will receive the information provided to the Intervention group after 3 months. All participants (both groups) will fill out a sleep diary, fill out a questionnaire and wear a watch that measures sleep. It is hoped that this research will help us understand whether a combined behavioural and bright light intervention can reduce sleep disruption and fatigue during chemotherapy for breast cancer and provide a basis for expanding the treatment to people with other types of cancer.

Left ventricular mural thrombus, which is identified in ~5% of patients after anterior ST elevation myocardial infarction, is a major risk factor for stroke. Anti-coagulation with warfarin is the currently recommended treatment. Direct oral anticoagulants (DOACs) such as factor Xa inhibitors apixaban and rivaroxaban, or the direct thrombin inhibitor, dabigatran, have a number of advantages over warfarin, and are an alternative treatment though not currently approved for this indication. There is currently limited randomised evidence to guide management of LV thrombus. This multi-center clinical trial will compare effects of DOACs versus warfarin on LV thrombus resolution and incidence of CV death, stroke, systemic embolism and major bleeding over a 3-month treatment period. Participants will be followed up annually for a period of 3 years to determine long-term health and participant reported outcomes.

The purpose of the study is to investigate the impact that ileostomy site placement has on patient quality of life. This study compares the traditional ileostomy in the right lower quadrant to a minimally invasive ileostomy formed through the umbilicus. The hypothesis is that a minimally invasive ileostomy through the umbilicus is better for the patient as: - There is no damage to the muscle when forming this umbilicus - It's midline position makes it easier for patient's to manage - There is not an extra incision made for this (umbilicus is a common site for port placement during laparoscopic (keyhole) surgery - Patient's are able to sleep on either side due to the midline position

The purpose of this study is to determine whether drowsiness during driving can be detected by using eye blink measures. In particular we are interested in determining whether eye blink measures differ between individuals with sleep apnoea and healthy individuals during their regular driving. Sleep apnoea participants will be matched with healthy participants in respect to age (within 5 years) and gender, It is anticipated that sleep apnoea group will be more tired and this will be demonstrated in their eye blink measures. The study is observational., The main outcome measures are eye blinks, self-reported and measured sleepiness, reaction times and driving habits.

Project GRIT (Growth, Resilience, Insights, Thrive) is a single arm pilot intervention study for children. The program is 12-weeks in length and involves exercise (high intensity interval training), healthy eating and psychological intervention (mindfulness and emotional freedom techniques) for children. The key research question of Project GRIT is: what is the effectiveness of a multidisciplinary intervention involving small-group exercise training and dietary education on metabolic fitness, body composition, cognitive performance, and diet quality in sedentary children aged 9 – 15 years living on the Gold Coast, Australia.

The primary purpose of this study is to validate the quasi-passive knee orthosis' functionality to allow further work It is hypothesized that: - When walking with the quasi-passive knee orthosis, while the leg wearing the orthosis is on the ground, the device will provide bending loads in 2 axes to reduce the loading on the knee. - Hip, knee, and ankle kinematics will remain unchanged. - The quasi-passive knee orthosis will be comfortable for the user to wear for an extended period of time and will have no soreness after use.

The purpose of the study is to investigate the effectiveness of compassion focused therapy as a treatment for body weight shame associated with obesity. Over the course of a 12 week compassion focused therapy program proposed by the Compassion Focused Therapy: Group Therapy manual by Gilbert, Kirby and Petrocchi (in press); participants will be assessed at pre, post and follow up times across primary and secondary outcome measures. Outcome measures are associated with mental health, compassion, relationship with food, physical health, and process variables.

This study aims to compare the effects of Betadine Sore Throat Gargle in decolonising nasal S. aureus, as well as to quantify the decrease in S. aureus numbers and the length of time it has an effect. This will be investigated in a healthy individual population who have persistent nasal colonisation with S. aureus. Three treatments will be compared. A control treatment with nasal application of saline. Mupirocin Nasal Ointment which is currently used for pre operative nasal decolonisation, and nasal application of Betadine Sore Throat Gargle. This is a crossover study design which means that each of the participants will receive all the three treatments. The outcomes examined in this study include to determine the efficacy of nasal application of Betadine Sore Throat Gargle in decolonising nasal S. aureus. To quantify the decrease in colony numbers. To determine the length of time Betadine sore throat gargle has an effect, and to see if it can provide absolute removal of nasal S. aureus. The findings of this study may help establish an alternative method of pre-operative nasal decolonisation of S. aureus.

This is a 2 stage study consisting of an initial open label study in ten (10) healthy volunteers to assess safety and iodine adsorption followed by a randomised, double blind, placebo controlled efficacy study in 258 participants exhibiting the common cold.

The primary purpose of this study is to test the test-retest reliability ad validity of a new scale created to measure the variety support received by students in their PE classes.