ANZCTR search results

The study is an Australian multicentre prospective imaging study performing multiparametric MRIs after acute reperfusion treatment for anterior circulation large vessel occlusion with cerebral perfusion, microstructural, metabolic and functional assessment at multiple follow-up time points. The project has received ethical approval from the Melbourne Health Human Research Ethics Committee (HREC). The HREC confirms that your proposal meets the requirements of the National Statement on Ethical Conduct in Human Research (2007). This HREC is organised and operates in accordance with the National Health and Medical Research Council’s (NHRMC) National Statement on Ethical Conduct in Human Research (2007), and all subsequent updates, and in accordance with the Note for Guidance on Good Clinical Practice (CPMP/ICH/135/95), the Health Privacy Principles described in the Health Records Act 2001 (Vic) and Section 95A of the Privacy Act 1988 (and subsequent Guidelines).

The study is an Australian multicentre prospective imaging study performing multiparametric MRIs after acute reperfusion treatment for anterior circulation large vessel occlusion with cerebral perfusion, microstructural, metabolic and functional assessment at multiple follow-up time points. The project has received ethical approval from the Melbourne Health Human Research Ethics Committee (HREC). The HREC confirms that your proposal meets the requirements of the National Statement on Ethical Conduct in Human Research (2007). This HREC is organised and operates in accordance with the National Health and Medical Research Council’s (NHRMC) National Statement on Ethical Conduct in Human Research (2007), and all subsequent updates, and in accordance with the Note for Guidance on Good Clinical Practice (CPMP/ICH/135/95), the Health Privacy Principles described in the Health Records Act 2001 (Vic) and Section 95A of the Privacy Act 1988 (and subsequent Guidelines).

This study will explore potential sex differences in skeletal muscle microvascular blood flow and other cardiovascular responses to acute maximal exercise in 34 healthy young adults (17 premenopausal females and 17 age-matched males). Microvascular blood flow will be assessed via contrast-enhanced ultrasound at rest, immediately after, and 30 minutes after completing a maximal graded exercise test. Additional assessments include heart and large artery function, body composition, physical activity levels, and blood sampling for biomarkers associated with cardiometabolic health. We hypothesise that healthy premenopausal females will have larger skeletal muscle microvascular blood flow responses to acute maximal exercise than age-matched males, reflecting their known greater vasodilatory responses in large arteries. Findings will inform sex-specific cardiovascular risk factors, and aid in the development of early detection strategies and more targeted prevention and management approaches.

This study aims to determine if a panel of salivary biomarkers could assist in the diagnosis of Barrett's oesophagus and its pathological variants, dysplasia and oesophageal adenocarcinoma. You may be eligible for this study if you are an adult male or female referred for investigation of reflux symptoms or other suspected gastrointestinal disease, as well as patients with established Barrett’s oesophagus and/or suspected or established oesophageal adenocarcinoma. Any patient with one of the Barrett's related conditions or random healthy patients who may undergo an endoscopy for another indication, maybe approached to consider participation in this study. Participants will be asked to contribute samples of saliva, blood and gastric fluid before undergoing an endoscopic procedure. This study aims to determine if a panel of salivary biomarkers could assist in the diagnosis of Barrett's oesophagus and its pathological variants, dysplasia and oesophageal adenocarcinoma. You may be eligible for this study if you are an adult male or female referred for investigation of reflux symptoms or other suspected gastrointestinal disease, as well as patients with established Barrett’s oesophagus and/or suspected or established oesophageal adenocarcinoma. Any patient with one of the Barrett's related conditions or random healthy patients who may undergo an endoscopy for another indication, maybe approached to consider participation in this study. Participants will be asked to contribute samples of saliva, blood and gastric fluid before undergoing their usual endoscopic procedure. It is hoped that findings from this study will help to develop a simple non-invasive saliva test to screen for oesophageal cancer.

This prospective cross sectional observational study aims to explore the protein and energy expenditure of patients with ulcerative colitis. Patients will undergo indirect calorimetry and nitrogen balance studies to determine their metabolic demand. The primary endpoint is nitrogen balance measured in nitrogen(g)/kg participant body weight/day. The secondary endpoint is resting metabolic rate in kcal/kg/day. Patient metabolic outputs will be compared to that of healthy controls. It is hypothesized that patients with ulcerative colitis do not have increased metabolic demands compared with healthy controls.

Polyphenols are naturally occurring colourful substances in plant foods, known to reduce blood glucose levels. The aim of this study is to investigate the ability of polyphenols enriched in bread to reduce blood glucose levels in healthy people. The polyphenol-rich extracts from spinach at 1-10% will be added to bread and taste-tested to choose the most accepted concentration for this study. Spinach is one of the vegetables that is versatile and known to contain high polyphenols content, where a cup of raw contains nearly 100 mg of polyphenols and 7x more in frozen products

A 12-week parallel-group randomised controlled trial examining the effects of a supervised resistance training on pain intensity, well-being, and inflammation compared to usual care in adults with chronic non-specific low back pain will be conducted. It is hypothesised that 12 weeks of resistance training will improve pain intensity, well-being and inflammation compared to usual care in adults with chronic non-specific low back pain.

To determine if a combination mitochondrial-based therapy using over-the-counter supplements can result in an improvement in the sensation of nerve-related pain in people with diabetes-related painful peripheral neuropathy.

Unfortunately, many people will experience knee osteoarthritis at some point in their life. This can be diagnosed by a General Practitioner (GP) or other health professional, and there are different ways this may be done. People often have beliefs about treatments for, and the prognosis of, their knee osteoarthritis. Currently, we do not know whether the way someone is diagnosed with knee osteoarthritis makes any difference to their beliefs about treatment or prognosis. This study is interested in learning more about whether the way people are diagnosed with knee osteoarthrtitis changes their beliefs about the condition. We hypothesise that a diagnosis and explanation without x-ray will reduce beliefs that surgery is necessary and increase beliefs that exercise is helpful, compared to a diagnosis and explanation based on x-ray.

In Australia, approximately one third of community-dwelling older people fall each year and the risk of falling increases with age. The consequences of falling can be fatal including fractures, institutionalising and loss of independence. The sport of judo includes a number of techniques and strategies that can be amended to teach older adults how to prevent falls and how to fall safely. This project aims to upskill Allied Health Professionals and Judo coaches to provide an 8-week Judo-based exercise program to older adults to teach them the core skills required to land safely from a controlled fall using a two-day workshop combined with practical experience by attending the 8-week Judo based exercise program. In addition, this project will evaluate how effective the 8-week Judo based exercise program is in improving safe-landing skills in community-dwelling older adults aged 65 years and older. Secondary outcomes will include balance, mobility, fear of falling, physical performance, strength and muscle mass, physical activity, and quality of life.