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Schools have been an ideal setting for intervention studies to take place. In PE settings, interventions targeting the psychomotor domain have been the most dominant. With amendments to educational policy, a gap has emerged where interventions targeting ‘other’ outcomes has promoted research into the cognitive, affective and social domains. This intervention study is aimed at evaluating the effect of social domains on high school students. This will be done through the Teaching Personal and Social Responsibility framework, developed by Don Hellison which was initially designed to re-engage students from low socio-economic status backgrounds in PE classes. Whilst TPSR studies have been scattered throughout the world with positive outcomes (academic and otherwise). TPSR has not yet been featured in high schools in Australia.

To date, Moderated Online Social Therapy (MOST) has only been trialled in clinical research settings with referrals from clinical services. The Evaluating the Impact of a Digital Youth Mental Health Service study: A pragmatic randomised controlled trial of a digital mental health service for youth with anxiety and depression (EVOLVE), seeks to extend upon previous feasibility, acceptability, and efficacy research in these settings by testing the effectiveness and cost-effectiveness of MOST in a real-world, community sample. Evolve is a prospective, parallel two-group, CONSORT-R compliant, superiority RCT. Young people in the general community aged 15-25 years, with self-reported anxiety and depression symptoms, will be recruited through a targeted social media campaign.

A 2 year clinical study to compare the clinical results of a new design to existing designs, of an acetabular hip cup aimed to resist dislocation while allowing normal motion, after total hip replacement surgery for patients 50 and over suffering a fracture of the neck of the femur. The study hypothesis is that at a minimum of 2 years, the new design is at least as safe and effective as existing standard total hip cups used to treat femoral neck fractures, and the new design reduces the risk of revision for dislocation in the first year versus those standard cups.

Pre-operative fasting is an important part of preparing for anaesthesia. Fasting reduces the volume and acidity of the stomach contents, which serves to reduce the risk of regurgitation and pulmonary aspiration. Fasting can be particularly stressful for young children, which can in turn lead to negative psychosocial and physiological outcomes. In this study, we wish to investigate if a pre-procedural carbohydrate-based chewables can help children to better tolerate pre-operative fasting.

Pre-operative fasting is an important part of preparing for anaesthesia. Fasting reduces the volume andacidity of the stomach contents, which serves to reduce the risk of regurgitation and pulmonary aspiration. Fasting can be particularly stressful for young children, which can in turn lead to negative psychosocial and physiological outcomes. In this study, we wish to investigate if a pre-procedural carbohydrate-based chewables can help children to reduce the negative effects of pre-operative fasting. We hope to provide evidence that these chewables are able to help kids tolerate fasting by improving their fasting discomfort, and reduce their post-operative nausea and vomitting.

This research study tests whether people, who are feeling unwell with an influenza-like illness, find swabbing themselves at home to be an acceptable method of detecting influenza and other viruses. Patients experiencing cough, fever, and fatigue will be provided with a home-swab kit by their GPs. After they swab themselves at home, patients will return the swab by post to the pathology provider, and answer survey questions about their experience.

Most babies born preterm have breathing problems shortly after birth, and many need help with their breathing. Clinicians have many treatments to help preterm babies breath, and know which treatments works best for most babies. But clinicians don’t know which treatments will work best for each baby. The BLUEPRINT Study aims to provide a more precise picture (phenotype) of how a specific preterm baby’s lungs are working in the first 7 days after birth. This will be achieved by combining information on the clinical care being used, measurements of lung function and the pattern of proteins in the blood collected 3 and 7 days after birth. We will then follow babies through until 2 years of age to measure their lung growth and function. By understanding the different lung phenotypes that exist in preterm babies, we hope to help doctors know which treatments may be best for a baby and predict which baby might be at more risk for lung problems as they grow up.

This study aims to evaluate the implementation of an evidence-based, multi-component intervention that improves the metabolic health and wellbeing of Aboriginal and Torres Strait Islander women before, during and after a pregnancy complicated by diabetes. The intervention consists of co-designed strategies, informed by previous research. The implementation will continue to use participatory approaches (co-design), with participants monitoring progress and collaborating to enhance sustainability. The mixed-methods evaluation of the implementation will: a) Explore the impact of the multi-component intervention on the metabolic health and wellbeing of participants at the study sites; b) Explore the impact of the multi-component intervention on the study sites (communities/services) as health promoting environments; c) Determine the acceptability and sustainability of the multi-component intervention at the study sites; d) Identify the enablers and barriers to implementation of the multi-component intervention.

This is a Phase 1, first-in-human (FIH), randomised, double-blind, placebo controlled study to evaluate the safety, tolerability, and pharmacokinetics (PK) of single ascending doses (SAD) and multiple ascending doses (MAD) of SION-451 administered as an oral suspension in healthy participants.

This is a Phase 1 study to evaluate the effect of food on the PK of SION-451 and the bioequivalence of a tablet formulation compared with the oral suspension formulation in healthy participants.