ANZCTR search results

The purpose of this project was to provide information for the development of online physical activity programs for older adults to improve well-being and reduce social isolation. This study assessed the feasibility, engagement, and acceptability of a 6-week online Qigong program delivered to community-dwelling older adults.

A new allied health transdisciplinary stroke assessment was designed and implemented at the Mater Hospital Brisbane acute stroke unit (2020-2023), replacing time-consuming and separate stroke assessments completed by occupational therapy, physiotherapy, speech pathology, and social work. The new assessment process helped the allied health professionals to streamline stroke services, saving assessment time and reducing occasions of service required to meet clinical and service goals and safely discharge patients from hospital. The proposed study is the translation phase of the work. The aim is to modify and implement the transdisciplinary stroke assessment in other settings, test if similar results can be achieved, and understand what factors drive success. The hypothesis states that compared to separate stroke assessments, the new transdisciplinary assessment will reduce allied health stroke assessment time by at least 35 minutes per patient in the initial occasion of service. This study has the support of the Queensland Chief Allied Health Officer.

Toe walking occurs in 5% of all children and 20% of children with autism spectrum disorder. It can result in foot and lower leg pain, contribute to falls and even bullying. Current treatment methods are time consuming, uncomfortable and ineffective. Textured insoles have shown to improve balance in children and adults. We do not know if either shoes or a textured insole will help children who toe walk. We are recruiting children aged 4 to 14 years who toe walk for no known reason or for sensory reasons to investigate if we can improve the amount or height of toe walking, balance or walking speed with the use of supportive sneakers with or without Naboso insoles. We are also determining the feasibility of the study and whether it can be conducted on a larger group of children

This study aims to evaluate the impact of the PANConnect intervention in addition to usual care on pain and symptom burden among patients with pancreatic cancer compared to usual care alone. Emotional distress, unmet needs, financial wellbeing, and the relative impact on health service use will also be assessed. Who is it for? You may be eligible to join this study if you are a patient aged 18 or older; have a confirmed diagnosis of pancreatic adenocarcinoma at any stage; have a life expectancy of at least three months, as indicated by your treating consultant; and are receiving your initial care at a trial site. You may also be eligible if you are a carer aged 18 or older or a healthcare professional providing or having provided care to participants with pancreatic cancer recruited to the trial. Study details: All patients who meet the eligibility criteria allocated to the PANConnect intervention continue to receive oncology care from their treating team, in addition to the PANConnect intervention. The intervention comprises the following: (1) weekly patient symptom-reporting, (2) symptom assessment and subsequent care coordination by a specialist cancer nurse (the PANConnect nurse) via telehealth, and (3) real-time communication of outcomes from telehealth consultations to the patient’s treating team. Before and after completion of the intervention, participants will be assessed for pain and symptom burden, unmet needs, financial wellbeing, emotional health and health service usage. It is also hoped that this research project will also inform the implementability of PANConnect and develop an effective scaling-up strategy to support future implementation efforts.

This study will evaluate the safety, feasibility and acceptability of a rehabilitation program (exercise and education) for people with lung cancer on immunotherapy. Who is it for? You may be eligible to join this study if you are a person aged 18 and above, have a histologically confirmed diagnosis of stage 4 lung cancer and are scheduled for or have commenced (within the last 6-months) immunotherapy treatment at Peter MacCallum Cancer Centre (Melbourne). Study details Participants in this study are randomly allocated (by chance) to one of two groups. Participants in one group will receive usual care at their treating hospital which does not routinely involve referral to rehabilitation services. Participants in the other group will receive a 12-week rehabilitation program of exercise and education delivered by a physiotherapist. The first session is conducted face-to-face to set up your exercise program and help you set goals. After this you will be able to attend twice-weekly group exercise classes for 12 weeks (conducted remotely by telehealth or at the hospital gym). The findings from this research will establish how feasible and acceptable it is to provide this rehabilitation service to those with lung cancer and support future research in the area.

The aim of this study is to investigate the acute effects of high intensity resistance exercise compared to balance & stretching on cognitive function (attention and inhibition) and affect in adults with ADHD. Selection criteria include those with an official diagnosis of ADHD, who are not physically active, have not recently engaged in resistance exercise (past 12 months) and currently have elevated ADHD symptoms on the Adult ADHD Self-Report Scale for DSM 5 (14+). It is hypothesised that resistance exercise will acutely improve attention (as measured by omission errors, hit reaction time and the sustained attention composite score) and inhibition (as measured by commission errors and the Impulsivity composite score) more than balance and stretching on the Conners Continuous Performance Test 3rd Edition. Participants will complete both exercise conditions in a randomised and counterbalanced order, one week apart at the same time of day, off medication.

The objective of the study is to evaluate the performance of the MyCellHealth (MCH) Test Kit in detecting abnormal cell metabolism in urine samples from known cancer patients, compared to samples from non-cancer patients. Who is it for? You may be eligible for this study if you are a male or female aged between 40 to 80 years old, attending one of the specialist clinics involved in this study. You will be recruited into cohort one if you are otherwise healthy and not known to have malignancy or following appropriate testing to have benign disease as adjudicated by the participant’s doctor. You will be recruited into cohort 2 if you have any known malignancy determined by the participant’s study doctor by way of routine diagnosis including, but not limited to physical examination, biopsy, pathology and/or imaging. Eligible participants were provided a urine collection pot with a label detailing their unique study ID at the end of their clinic visit to provide a sample of first void urine. Women of childbearing potential were asked to complete a urine pregnancy test and if positive, were deemed a screen fail and exited from the study. Participants were encouraged to provide a first void, midstream sample of 40 to 50ml of urine into the pot the following morning. After the participant had collected a sample of their urine, a pathology courier collected the sample on the same day to take to the lab for testing. The Core Lab analysed the results using the MCH Test Kit according to the Instructions for use, using the Pantone colour chart provided. A positive or negative result was recorded in the Electronic Data Caption system. It is hoped that findings from this study will help detect potential cancer early and improve cancer outcomes.

When your knee gets a tear in the meniscus (a part of your knee), it can really hurt and make it hard to do things you enjoy or even work. At Bendigo Health, people with these knee problems often have to wait a long time to see a doctor. This can be up to 5 years. Recent studies and guidelines suggest that surgery is not the only option for most cases of knee meniscus pain. Experts say that one of the best things for knee meniscus pain is learning about your condition, doing specific exercises, and getting advice on changing your lifestyle. At the moment, patients don't always get this kind of help. So, we're trying something new. We want to see if an online program that teaches you about your knee and gives you exercises can help. We're checking if this can make your knee hurt less, make it easier to move around, and make your life better.

K-3505 P001 (Part II) is a Phase 1 study with a primary purpose of assessing the safety and tolerability of single doses of an intravenously (i.v) administered drug called K-3505 when K-3505 is administered alone (Day 1) and when K-3505 is administered after prior oral administration of another drug called Fezolinetant (Day 2).

Hypoglycaemia (hypo) education is provided at the time of type 1 diabetes diagnosis and knowledge reviewed in the clinic as required. The current threshold for initiating hypo treatment at glucose level < 3.9 mmol/L is on expert opinion, rather than evidence based, which was chosen to avoid glucose levels from dropping even further (<3.0 mmol/L), considered as significant hypoglycaemia below which neurocognitive decline occurs. However, it needs to be appreciated that levels between 3.0 and 3.9 mmol/L are considered as normal in healthy individuals with no diabetes. With the availability of continuous glucose monitoring (CGM) and closed loop therapy as standard care in management of T1D, there is ability to support lower glucose thresholds for treatment as basal insulin delivery is suspended with prediction of a hypo. This will avoid overtreatment of hypos and resultant high glucose levels. The study aims to determine if reducing the cut-off of initiating treatment will be an acceptable hypo threshold and will not be associated with an increase in time spent in hypos <3.0 mmol/L with worsening of glycaemic outcomes.