ANZCTR search results

This study will investigate the proportion of adults patients who undergo liver transplantation who receive an ultra massive transfusion. Ultra-Massive Transfusion is a relatively new term that has generally been accepted to describe the transfusion of >20 units of packed red blood cells in 24 hours. There is a paucity of literature on ultra massive transfusion, which has almost exclusively been studied in the context of trauma surgery, where it is associated poorer postoperative outcomes and increased mortality. This retrospective single centre study will use electronic medical records from the Austin Health database from 1st Jan 2019 to to 1st January 2023. We will evaluate the outcomes and complications in patients undergoing liver transplant surgery who receive ultra-massive transfusion. These results may be used to aid prognostication of post-operative liver transplant patients, as well as identify, and therefore modify, factors that may predispose patients to poorer post-operative outcomes, ultimately aiming to reduce overall morbidity and mortality in this patient cohort.

Psoriasis is a chronic inflammatory skin disease that entails a significant risk of cardiovascular disease. Mitigating this risk through patient led primary and secondary prevention must be a treatment priority. This study aims to improve psoriasis patient activation (i.e. knowledge, skills and confidence), with respect to cardiometabolic health through the use of a text message intervention program, aimed at CVD prevention. We hypothesize that a structured text-messaging intervention of education- and lifestyle- targeted text messages, will improve psoriasis patient activation (knowledge, skills and confidence) regarding their health, preventative cardiovascular disease self-management and clinical outcomes compared to usual care.

The BUBs Quit individual randomised controlled trial aims to determine the effectiveness of the BQ smoking cessation intervention compared to standard care for pregnant women who smoke with regards to primary and secondary maternal and child health outcomes including smoking cessation at 3 months postpartum. The BQ study will comprise three concurrent phases: impact (phase 1), economic (phase 2) and implementation evaluations (phase 3).

To evaluate the accuracy and reliability of transabdominal and trans-perineal ultrasound in assessing the rectum, using colonoscopy or flexible sigmoidoscopy as the reference standard, and to explore the impact of subcutaneous adipose tissue(SAT) and bladder fullness on image quality and accuracy.

The purpose of this study is to determine the effect of an online mindfulness program (Carer_MindOnLine) among caregivers of people living with cancer. Who is it for? 200 adults who are experiencing higher burden while caring for people living with cancer will be invited to participate via social media platforms and cancer registries. Study details People will be allocated to one of two groups by random chance: the intervention group with immediate access to Carer_MindOnLine, or a usual care group who will receive the intervention after the follow up period. Carer_MindOnLine is a 9-week program where a new theme is introduced each week with a new meditation practice. People will be encouraged to practice mindfulness every day. At the end of the 9 weeks, participants will be asked to complete a series of surveys. It is hoped that this research will help determine whether mindfulness will be an effective method of assisting people in managing fear of cancer recurrence, anxiety, and depression.

The purpose of this study is to examine the feasibility and acceptability of an intervention that identifies the unmet social needs (e.g. housing and financial insecurity) of vulnerable caregivers and employs Health Navigators (HNs) to provide appropriate referrals to government and community resources and ongoing advocacy over a four-month follow-up period. HNs are non-medical workers who have experience with the community service sector who practice strengths-based approaches to understand participants' situations and be led by them in designing an action plan for their needs. We hypothesise that HNs may be able to engage participants with services and may be able to resolve some of their needs. Our primary outcome of interest is the feasibility and acceptability of the intervention for both participants and clinicians working in the Children's Ward. These will be assessed using mixed-methods methodology, i.e. focus groups with participants and clinicians, and objective feasibility criteria such as rate of intervention recruitment and retention.

When residents are transferred across settings their health information is often not shared optimally, impacting the care they receive. Accurate communication of health and medical information at point-of-care during and after a transfer has been shown to reduce avoidable hospitalizations, shorten length of hospital stays and reduce ambulance call outs and transfers. We have co-designed, in partnership with staff representatives from the aged care, IT and the clinical sector, as well as aged care residents and their informal carers, a prototype digital health summary system for sharing agreed upon point of care information considered critical during the transfer of people living in residential aged care. Therefore, the aim of this study is to test the feasibility of the digital health summary and its effectiveness in reducing ambulance transfers and hospital presentations to generate preliminary data on intervention effectiveness. To achieve this aim, we will recruit 3 RAC homes for prototype testing using sequential pre-post study designs (one for each site). This will allow us to evaluate, learn and refine our implementation over 3 iterations, learning from the failings/barriers encountered in each previous attempt. We will use routinely collected hospital and Ambulance Victoria data to determine the impact on our primary, secondary and adverse event outcomes.

This study aims to achieve a deep understanding of UCH’s Rapid Response System (RRS) operations and how the hospital adopts and integrates new technologies, particularly robotic systems, into its healthcare setting. By adopting a qualitative methodological approach, combining semi-structured interviews, focus groups, and direct observations, the research seeks to capture comprehensive insights from medical professionals, nursing staff, Allied Health professionals, support staff, and hospital administrators. These insights will focus on the experiences, perceptions, and suggestions for the integration of robotic technologies, aiming to identify challenges, opportunities, and potential impacts on workflow, patient care, and overall healthcare delivery. Through this exploratory study, findings are expected to inform the broader application and adoption of robotic systems in healthcare environments, laying a foundational understanding for future research and development in this emerging field.

The purpose of this clinical investigation is to confirm the clinical performance and safety of the HOYA Vivinex™ Gemetric™ Plus Toric preloaded IOLs versus comparator Alcon Acrysof® IQ PanOptix® Toric Trifocal IOLs. The medical indication is the implantation with a Vivinex™ Gemetric™ Plus Toric preloaded IOL for visual correction of aphakia and pre-existing corneal astigmatism after implantation into the capsular bag in adult patients who desire near, intermediate and distance vision with increased spectacle independence. The primary hypothesis is based on the primary performance endpoint, that is the percentage of patients achieving 0.3 LogMAR monocular distance corrected near visual acuity (DCNVA) when measured at 40cm at 6 month visit among subjects implanted with the HOYA Vivinex™ Gemetric™ Plus Toric preloaded IOLs will be non-inferior to that of subjects implanted with the Alcon Acrysof® IQ PanOptix® Toric Trifocal IOLs.

The current study aims to further understand what factors related to the individual and their families influence treatment outcomes in eating disorders. We hope to improve our assessment procedures so we can provide more effective treatment. Whilst there are evidence based treatments for eating disorders, no treatment is effective for all. We hope to be able to uncover which treatments are best for which individuals and families, and be able to better match the treatment that is best suited. We hope that this research will improve our treatment here at the Eating Disorders Program. Additionally, we hope to publish our findings so that individuals and families around the world may receive better treatment.