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This study aims to evaluate a new method, the IRIS protocol, for administering drug provocation tests to patients with suspected drug allergies during surgery. The IRIS protocol gradually increases the drug dosage more slowly than the standard method, potentially reducing the risk of severe allergic reactions. We hypothesize that the IRIS protocol will result in lower drug doses at the time a reaction is detected, making it a safer alternative to current practices.

The study has two parts: A and B. This information is for part B. Part B of the study will test the safety and efficacy of giving 4 doses of fludrocortisone (study drug) to people with geographic atrophy (GA), which is an advanced form of age-related macular degeneration (AMD). Age-related macular degeneration (AMD) is a disease of the macula, an area in the retina found at the back of the eye, needed for sharp, clear vision and activities such as reading and sewing. The advanced form of dry AMD is known as geographic atrophy (GA) (a region of the retina where the cells wither away and die). Sometimes, these regions of GA look like a map to the doctor who is examining the retina, hence the term “geographic atrophy.” The purpose of this study is whether fludrocortisone (study drug) is safe to give to people with GA and if it can prevent or slow down the progression of GA.

OA is a condition that affects the joints and causes pain and stiffness. In Australia, around three million people have OA, but the way we currently treat OA isn't always based on the best evidence. Sometimes, the care is not well coordinated, not very helpful, or not suitable for the person's needs. The COASTAL study is a research study testing three different ways of providing this care: in-person (face-to-face), or through technology like telehealth (video or phone calls) or using an online app. This research study will compare how well these different programs work at improving pain for people with knee OA. We hope the results of this study will help policymakers and healthcare providers decide on the best way to organise services for people with knee OA. We hypothesise that the three methods of delivering knee OA management programs will be non-inferior to each other for reducing average knee pain on walking.

Transplantation of initially unsuitable livers following extended organ perfusion is an open-label, non-randomised, prospective, single-arm trial, using normothermic extended organ perfusion to test viability and then transplant marginal livers. It will be conducted at the Australian National Liver Transplant Unit (ANLTU) at Royal prince Alfred Hospital.

Atrial Fibrillation (AF) remains the most prevalent heart rhythm disorder. AF causes morbidity and mortality, and also a negative effect on human sexual function. Furthermore, catheter ablation is an effective method of AF treatment, and the influence it has on human sexual function is unclear. This study hypothesises that catheter ablation will have a positive effect on human sexual function. This study aims to describe the effect of catheter ablation on human sexual function.

Around 35% of labours are induced, and the rates are rapidly rising. Most induction start with 'cervical ripening', traditionally an invasive procedure with a balloon device or hormonal medication administered vaginally in hospital. Low-dose oral misoprostol is a promising alternative - less invasive, can be administered in an outpatient setting, and associated with fewer caesarean sections and equivalent rates of uterine stimulation compared to balloon methods. However, limited clinical trials have directly compared it to balloon methods, none within an outpatient setting. Therefore, we will compare low-dose, oral misoprostol with balloon methods for induction of labour to determine intervention feasibility and acceptability within two-discrete randomised controlled trials within the Sunshine Coast University Hospital and Royal Brisbane and Womens' Hospital. As the context of the intervention (inpatient or outpatient) is likely to influence outcomes, an initial study will be used to assess feasibility and ensure safety and acceptability in the inpatient setting and if it meets a priori criteria the second study will be conducted to demonstrate the same measure in an outpatient setting.

When people with Diabetes exercise it can make their blood sugar drop too low, for this doctors recommend ways to adjust insulin before exercising. SGLT Inhibitors can increase the risk of Diabetic Ketoacidosis. The Abbott Sensor-Based Ketone Monitoring system will be used to assess the effect ketone responses during exercise in people with type 1 diabetes. We believe that ketones will risk in individuals that undertake high intensity interval exercise.

Incorporating dexmedetomidine into a comprehensive sleep promotion bundle, which includes minimising night-time disruptions and aligning care activities with the patient’s natural sleep-wake cycles, optimising the sleep environment through monitoring temperature, noise and ambient light could significantly enhance sleep quality in ICU patients. Improved sleep may contribute to better recovery outcomes, reduction in delirium incidence, and overall improved patient well-being. The primary objective of this trial is to provide a comprehensive evaluation of the efficacy and safety of dexmedetomidine in improving sleep in adult ICU patients as part of a sleep promotion bundle as determined by the patient’s subjective sleep assessment.

K-3505 P001 (PART I) is a study of an intravenously (i.v.) administered drug called K-3505. This study which will be conducted in healthy volunteers is a double-blind, placebo-controlled, single rising dose study with a primary purpose of assessing teh safety and tolerability of single i.v doses of K-3505.

Improving GP care for people with gout and antidepressant prescription in older adults have been identified as priority areas for Quality Use of Medicine (QUM) programs in the Quality Use of Diagnostics, Therapeutics and Pathology (QUDTP) guidelines. The aim of this trial is to determine the effect of co-designed, tailored and facilitated educational interventions in improving the quality use of medicines in general practice for people with gout and older adults prescribed antidepressant medication. Each group will act as the other’s control. Both groups will have access to educational resources available on demand for both topics via the Medcast online education platform. The study hypothesis is that co-designed, tailored and facilitated educational interventions will be effective in improving general practice care for people with gout and older adults prescribed antidepressant medication.