ANZCTR search results

The low FODMAP diet is an effective symptom management approach for 50-75% of individuals with irritable bowel syndrome (IBS), leaving 25-50% as non-responders. Determining predictors of treatment response at the individual level during all three-phases of the low FODMAP diet are lacking. The aim was to investigate predictors of symptom response to the low FODMAP diet in patients with IBS. Adult IBS participants undertook the low FODMAP diet via one-on-one dietetic education including elimination, reintroduction and personalisation phases. Predictor variables included levels of depressive, anxiety, and extraintestinal somatic symptoms, stress, treatment beliefs and expectations, behavioural avoidance, and illness perceptions. Symptom severity and quality of life were the outcome variables. Questionnaires assessing psychological predictors, symptoms and QoL were completed at five timepoints: pre-dietitian (week 0), immediately post-dietitian, at the end of the elimination (week 5), reintroduction (week 13) and personalisation (week 25) phases. Statistical analyses will assess the predictive relationships between psychological predictors and symptom severity.

We aim to determine whether the My Emotions intervention, delivered by provisional psychologists in their usual work setting, is feasible, acceptable, and effective. Therefore, in this waitlist controlled randomised controlled trial, we aim to determine whether a brief emotions intervention delivered by provisionally registered psychologists: 1. Is feasible and acceptable when delivered in real life clinical settings (primary outcome) 2. Decreases emotions problems as measured by the Strengths and Difficulty Questionnaire (SDQ) at 3-months post randomisation follow-up (secondary outcome).

This study is seeking to understand the relationship between exercise health service utilisation and other patient factors including diagnosis, cancer-related medical treatments and geographical location. Furthermore, the study will also look at patient’s current experiences around referral to exercise services and barriers related to this. Who is it for? If you are an adult with a diagnosis of cancer, any type and stage, living in NSW and able to give informed consent. Study details Participants will be participating in a semi structured group interview and be asked about their experience with advice about exercise and referral to exercise services after a cancer diagnosis. Participants will also complete a questionnaire detailing their demographic information. This research hopes to improve access to exercise services for people with cancer.

The current research project aims to test the efficacy of an enhanced version of the Study Without Stress program (i.e., SWoS-social) among high school students completing their final high school exams i.e., Higher School Certificate (HSC). To test its efficacy, we will implement a counterbalanced design and include measures of academic stress and social connectedness. We hypothesise that there will be an association between social connectedness and academic stress pre-treatment, and that students will experience a reduction in stress and increase in social connections pre- to post- SWoS-social program. Further, students who experience an increase in social connectedness throughout the SWOS-social program will experience lower academic stress post treatment. The outcomes of this study will further our understanding of the importance of social connectedness among high school students, as well as test the efficacy of an enhanced social version of the SWoS program for reducing stress.

Participants from a previous quit smoking clinical trial who have experience using NVPs for smoking cessation and have reached different points in their quit journey will be asked to participate in this qualitative project. The study will use in-depth interviews to explore the barriers and facilitators of quitting smoking using NVPs and gain insight into how ex-smokers switch away from NVP use. These insights will be further explored and built upon in focus group sessions, which will allow participants to share their ideas for a text message program that helps smokers quit both tobacco smoking and vaping. This can include changes to the existing types of messages, message style, how specific or tailored they are and other features.

This study aims to explore the effects of a 4-week dietary fibre powder developed by ECU, known as urgut, (Provisional Patent 2023902137) as a dietary fibre powder in well-trained endurance athletes and community members with gastrointestinal (GI) disturbance. Outcomes of interest will be gut symptoms, gut transit time, gut microbiota and biomarkers of gut health in both stool and blood, as well as self-reported mental health, and quality of life.

Maintaining a normal temperature after birth is a major challenge for newborn survival and morbidity. Preterm infants less than or equal to 34 weeks’ gestation and less than or equal to 1500g weight are especially vulnerable to cold stress/hypothermia. Recommended interventions to prevent thermal loss at birth in preterm infants include moderation of environmental temperature, infant warmers, polythene bags/wraps, preheated mattresses, and heated and humidified gases. This randomised controlled trial compares two modalities (servocontrolled patient temperature management system vs. current standard) of thermoregulation during the transport of preterm and low birth weight babies soon after birth. We hypothesise that the servocontrol patient temperature management system will be more effective at maintaining babies temperature within normal range of 36.5-37.5 degrees Celsius. We aim to compare these two modalities to see which one is more effective at maintaining babies temperature during transport as a primary outcome and see whether it affects morbidity and mortality of preterm/low birthweight babies as a secondary outcome.

Patellofemoral pain (PFP) is the most common cause of knee pain in young adults (18-40 years), affecting 1 in 4 people and increasing the risk of knee osteoarthritis. This study will evaluate the feasibility of delivering an online education, exercise and anti-inflammatory food program for people with PFP delivered over 12 weeks.

We are undertaking a randomised controlled trial to test if it is feasible to conduct a full scale study of the safety and effectiveness of peer worker (people with lived experience of living and working in the farming community) delivered behavioural activation (a brief evidence based psychological treatment for depression) for people with moderate to severe depression. We want to find out if it is possible to recruit and train peer workers, if they can sucessfully deliver the intervention and if people from farming communities will agree to participate in a clinical trial.

Urinary tract infections (UTIs) are the most common postoperative complication following Botox injection in the bladder. The risk of UTI is approximately 24%. This study will see if taking a tablet of hiprex twice a day for six weeks could decrease the risk of urinary tract infection after Botox treatment. Hiprex is a medication that reduces the incidence of urinary tract infections in women with repeated urinary tract infections. We are comparing this to our current practice, where no further preventative medications are given other than the standard antibiotics during the procedure that everyone receives.