ANZCTR search results

We need to answer key questions about the efficacy of apps that have been based on proven therapeutic approaches (can they reduce suicidal ideation and improve wellbeing compared with a control, are effects portable from one country to another?), and to understand if these apps are acceptable (are these apps engaging for youth, including rangatahi Maori), and safe (do they cause unintended harms). Answering these questions is the aim of this world-first international trial. We hypothesise that the use of all of the test apps (but not the control app) will result in reduced suicidal ideation. We also hypothesise that apps developed in NZ will be better for NZ young people and the same for Australian apps for Australian young people.

This study is evaluating a new technology called intracardiac echocardiography (ICE) to assess if tumours are compressing, or invading the major abdominal blood vessel, the inferior vena cava (IVC). Who is it for? You may be eligible for this study if you are an adult with a retroperitoneal sarcoma who has radiological evidence (CT/MRI) demonstrating compression or involvement of the IVC, and are scheduled for tumour resection at Sir Charles Gairdner Hospital in Perth, Western Australia. Study details Participants will undergo ICE which is a day case procedure performed under local anaesthetic, involving passing a small catheter into the IVC to assess the degree of involvement of the tumour. It is hoped that by accurately distinguishing between patients with true IVC invasion and those with compression preoperatively will allow us to reduce unnecessary additional invasive procedures in patients that they do not ultimately need. This approach will allow for more effective scheduling of the operative lists and improve efficient use of theatre resources, including staff.

The AFL Brain Health Initiative is a prospective, longitudinal clinical research program designed to monitor player brain health across the lifespan, and explore both protective contributors and risk factors for long-term brain health. The research design therefore aims to answer key questions regarding the prevention, diagnosis and management of sport-related concussion (SRC) and repetitive head impacts, and potentially enable identification of players at risk of poorer outcomes following retirement to inform education and intervention to reduce risks.

The aim of this study is to look at how much energy the body uses to digest, process and store the food that is eaten after a meal (referred to as meal -induced thermogenesis) and if there are differences between ethnicities. Understanding how the body uses energy may help us towards explaining observed differences in body composition (fat and lean mass) between people of Asian and Caucasian ethnicities and susceptibility of developing chronic diseases. The hypothesis is Asians will have a lower meal induced thermogenesis compared with Caucasians.

This study aims to compare the effects of a 12-week high-intensity interval training (4x4 HIIT: 4 x 4min at 85%-95% max HR with 3 min of rest) on brain and systemic vascular function in healthy late perimenopausal women against an energy matched moderate-intensity interval training ( 6.5x4 MIIT: 4 x 6.5min at 65%-75% max HR with 3 min of rest)) and non-exercising time control group. This will be investigated as a randomized controlled trial at the University of Queensland. In total we hope to recruit 36 participants to be randomized into either a HIIT, MIIT or a time-control group. Measures of brain and peripheral vascular function, arterial stiffness, hormone levels, vasomotor symptoms (hot flushes), cardiorespiratory fitness and body composition, will be taken prior, during, and following the intervention. We hypothesize that the HIIT group will produce the greatest improvements in cerebrovascular and peripheral vascular measures, when compared to the MIIT and time control group. The findings from this investigation will inform practitioners about how to optimise targeted exercise therapies for vascular disease prevention in women undergoing menopausal transition.

This study is a single-case experimental design (SCED) study with longitudinal follow-up aiming to evaluate the therepeutic benefits for individuals with neuromusculoskeletal impairments participating in a self-selected, performance-focused Para-sports training program. Participants involved in this project are currently enrolled in the ParaSTART (service) program and will undertake structured training in the sport of their choice and will be closely monitored in relation to sport-specific performance, psychosocial responses, fitness, health, independence and well-being. In SCEDs, each participant serves as their own control, with responses monitored during active training periods and recovery periods. SCED outcomes will demonstrate how self-selected sports participation affects health, functional independence and quality of life. Following the SCED, participants will be encouraged to continue training and monitoring for as long as they wish (ongoing service). This longitudinal follow-up is consistent with the current ParaSTART ( model which has run continuously since 2016. It is believed that participating in a performance-focused sports training program for a long period of time will improve not only the participant's ability and sporting performance, but also have benefits to their health, fitness, functional independence and mobility and psychological health and wellbeing.

Rationale: To increase uptake of HIV testing by distribution of HIV self-testing using a social network-based approach. Purpose: To examine the effectiveness of SNA in distributing HIV self-testing kits among MSM. Study design: Each test promoter will then receive four HIV self-test kits via mail, one for himself/themselves to use and remaining three for him to distribute to his social network or sexual partners, preferably overseas-born MSM. Test promoters will be required to distribute the HIVST kits to his social network or sexual partners within 3 months. All participants will be required to complete a post-HIV self-test survey and report their test result.

Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most discussed health topics on social media, with an increasing rate of individuals self-diagnosing based on online content. However, some of the content consists of misleading or misrepresentative symptom descriptions, which may contribute to misdiagnosis, overidentification, and unnecessary distress. This study aims to examine the impact of different types of ADHD-related TikTok posts (personal anecdotes vs. awareness campaigns) and the accuracy of symptom descriptions (evidence-based vs. misrepresentative) on participants' perceptions, emotions, and self-diagnosis intentions. It is hypothesised that personal anecdotes will evoke higher intentions to self-diagnose, internalized stigma and emotional engagement, but lower intentions to seek an official diagnosis and perceptions of credibility compared to awareness campaigns. Further, content featuring misrepresentative symptoms is hypothesised to lead to higher intention to self-diagnose, stigma, and stronger emotional responses. Interaction effects are anticipated, with personal anecdotes containing misrepresentative symptoms eliciting the highest intention to self-diagnose, stigma, and emotional response, while awareness campaigns containing evidence-based symptoms are expected to result in the highest intention to seek an official diagnosis and credibility. Given the increasing influence of social media on health perceptions and self-diagnosis behaviors, this study will provide valuable insights into how different types of ADHD-related online content affect individuals' understanding and decision-making. The findings can contribute to discussions on responsible health communication, misinformation, and the potential risks of self-diagnosis based on social media content.

This study is being undertaken to evaluate the safety and clinical effectiveness of the M-Finity Femoral stem with a Medacta Acetabular Cup in primary total hip arthroplasty through a CT-based migration analysis. The purpose of this study is to assess the safety and clinical effectiveness of the M-Finity in a pilot study on a small patient series. This will be achieved by both assessing the adverse events and conducting a stem migration and rotation analyses on patients who are having the M-Finity device.

This study aims to investigate whether laser acupuncture can enhance brain and motor function in healthy adults. Laser acupuncture is a non-invasive technique that applies low-level laser therapy to specific acupuncture points to stimulate physiological responses. This research will compare the effects of real and sham laser acupuncture on corticospinal excitability and sensorimotor function. The findings may help improve our understanding of how laser acupuncture influences the nervous system and whether it has potential applications in rehabilitation or performance enhancement.