ANZCTR search results

This study aims to examine the feasibility of a mobile application to collect follow up health data about Hodgkin Lymphoma survivors. Who is it for? You may be eligible to participate in this study if you are a patient aged 18 years or over, and must have received treatment for histologically confirmed classical HL according to the WHO classification. Study details Participants will enter their Hodgkin treatment and lymphoma response information, then complete a quesitonnaire on their current medical health including cardiac, respiratory, fertility, endocrine health. It is hoped that the results of this trial will help improve the lives of HL survivors.

The question of this study is: Would access to e-bikes combined with behavioural support enable sedentary adults to improve their levels of physical activity? The study aims at exploring the effects of e-biking combined with behavioural support on levels of physical activity. The hypothesis is that the MI-CBT supported intervention results in attainment of physical activity guidelines among previously inactive participants.

This program of research aims to safely reduce antibiotic use by supporting the implementation of best-practice Antimicrobial stewardship guidelines in general practice. These resources will support GPs treating adults with acute respiratory infections (ARIs). A UOW research team and collaborators, led by Profs Andrew Bonney and Judy Mullan, has been successful in being awarded a Medical Research Futures Fund grant (ID: MRF2029531) to conduct this research. This study is called the Optimal Implementation of Antimicrobial Stewardship in General Practice (OPTIMAS-GP) study. This pilot study will inform a larger randomised control trial.

In this study, we are interested in looking at the acute effects of the anti-Parkinson drug, levodopa/carbidopa (Sinemet®) on the rate of stomach emptying, blood pressure and abdominal blood flow after a sugary drink, and the relationship between the rate of stomach emptying and the rise in levodopa levels. The primary hypotheses underlying the study are that (i) a therapeutic dose of levodopa (200mg) / carbidopa (50mg) will slow gastric emptying in patients with mild to moderate Parkinson’s disease and (ii) this slowing of gastric emptying will be associated with an attenuation in the fall in blood pressure, and the rise in superior mesenteric artery (SMA) blood flow, after oral glucose.

The transition from hospital back into the community can be a difficult time for patients to navigate due to the involvement of multiple health professionals, medication changes and complex health care plans. These factors place patients at risk of medication-related harm during the transition of care (ToC) period. This study will use a prospective pre-post interventional study of a locally appropriate pharmacist-led interdisciplinary transition of care service for high-risk cardiology patients across three tertiary Queensland hospitals. We hypothesise that this will help to reduce 30-day medication related readmissions to hospital.

This study is a stepped wedge randomised controlled trial aimed at investigating the implementation and clinical effectiveness of multidisciplinary post-discharge bundles on preventing readmission for older people transitioning from hospital to residential aged care for the first time. This will be carried out at multiple hospital sites in three local health networks in South Australia. Eligible patients will be stratified according to their risk of readmission and will receive a customized post-discharge bundle of interventions based on their assessed risk. The outcomes are 30- and 90- day readmissions after the index discharge and length of stay out of hospital. Process evaluation will include the acceptability, adoption, feasibility and fidelity of implementation.

The aim of this study is to determine the feasibility of giving ketone bodies in the form of dietary supplementation to patients with acute neurological injury admitted to ICU in order to improve neurological outcomes. This study will use be a randomised controlled trial, a well known study design that eliminates study biases that can confound findings as much as possible in order to determine the true utility of the use of ketones in brain injury. Patients who are in a coma with an acute brain injury, admitted to ICU, will be eligible to participate in this trial. Participants will be randomised (like the toss of a coin) to routine administration of ketone bodies via a feeding tube on admission and standard care, or placebo and standard care alone. Ketone body supplementation is currently not available for ICU patients and will only be available within this trial. Determining the feasibility of giving ketone bodies to patients with acute brain injury admitted to ICU is the first important step in a program of research that ultimately aims to test the efficacy of using ketone bodies in this group of patients to improve neurological outcomes and reduce disability.

We want to test smart shoes. We want to see if wearing these shoes decreases falls for people with Parkinson’s disease. We can monitor your walking at home when you wear these shoes. In this project we want to test a new way of obtaining objective measures of walking and falls risk in people with Parkinson’s Disease using novel technologies allowing continuous monitoring at home. For this pilot study we want to test the usefulness of such an approach using newly developed smart shoes (‘NUSHUs’, developed by our industry partner Magnes AG) with built-in sensors that study participants can use for walking or exercising at home. These shoes are not approved by the TGA in Australia. The shoes continuously record your mobility. The smart shoes collect data while you are walking or exercising and processes the data using advanced methods. During the study you will receive a training program tailored specifically to your individual needs to complete while wearing the smart shoes. The collected data can be accessed by the treating team so they can track your progress and guide you further via telehealth or in person reviews. By understanding how such a technique can be incorporated into clinical practice, this research will contribute to exploring modern management approaches for patients suffering from Parkinson’s Disease.

This study aims to examine the effectiveness of a practice change intervention (IMPACT- CVD in CANCER clinic) in increasing the proportion of patients with cancer who receive complete baseline CV risk assessment and guideline-directed management, and guideline- directed surveillance. Who is it for? You may be eligible to participate in this study if you are patients aged 18 years or over, and diagnosed with cancer; and are about to start cancer treatment with medications that are known to, or thought to, increase risk of heart disease. Study details Participants included in this study may either have their baseline cardiovascular risk assessment conducted as per usual practice, or with a structured cardiovascular risk assessment tool and nurse-led cardiology clinic that is being tested for this study. The risk assessment that participants receive will depend upon the hospital they are being treated at and the timing of their appointments; as all participating hospitals will be allocated to start using the new clinic and cardiovascular risk assessment at different times throughout the study. All participants will receive the best standard of care regardless of whether the hospital they are attending has been allocated to use the new nurse-led clinic or not. Participants may be asked to complete three 15-minute surveys (at baseline, at 6 months, and 12 months after their cancer treatment). It is hoped that the results of this trial will help improve the experiences of care for patients receiving cancer treatment. This study seeks to find out if the cardiovascular risk assessments and education clinic helps improve the experiences of care for patients receiving cancer treatment.

This trial investigates the impact of daily consumption of two apples or two pears on cardiometabolic disease risk factors, biochemical (fingerprints) changes, and microbiome function. Adult volunteers at risk of developing cardiometabolic disease are eligible for this study. Participants will be randomly assigned to consume apples for 8 weeks, followed by a 4-week washout period, and then another 8 weeks of pears, or vice versa. It is hoped that this study will support improved health outcomes from consuming apples or pears.