ANZCTR search results

A 2 year clinical study to compare the clinical results of a new design to existing designs, of an acetabular hip cup aimed to resist dislocation while allowing normal motion, after total hip replacement surgery for patients 50 and over suffering a fracture of the neck of the femur. The study hypothesis is that at a minimum of 2 years, the new design is at least as safe and effective as existing standard total hip cups used to treat femoral neck fractures, and the new design reduces the risk of revision for dislocation in the first year versus those standard cups.

Pre-operative fasting is an important part of preparing for anaesthesia. Fasting reduces the volume and acidity of the stomach contents, which serves to reduce the risk of regurgitation and pulmonary aspiration. Fasting can be particularly stressful for young children, which can in turn lead to negative psychosocial and physiological outcomes. In this study, we wish to investigate if a pre-procedural carbohydrate-based chewables can help children to better tolerate pre-operative fasting.

Pre-operative fasting is an important part of preparing for anaesthesia. Fasting reduces the volume andacidity of the stomach contents, which serves to reduce the risk of regurgitation and pulmonary aspiration. Fasting can be particularly stressful for young children, which can in turn lead to negative psychosocial and physiological outcomes. In this study, we wish to investigate if a pre-procedural carbohydrate-based chewables can help children to reduce the negative effects of pre-operative fasting. We hope to provide evidence that these chewables are able to help kids tolerate fasting by improving their fasting discomfort, and reduce their post-operative nausea and vomitting.

This research study tests whether people, who are feeling unwell with an influenza-like illness, find swabbing themselves at home to be an acceptable method of detecting influenza and other viruses. Patients experiencing cough, fever, and fatigue will be provided with a home-swab kit by their GPs. After they swab themselves at home, patients will return the swab by post to the pathology provider, and answer survey questions about their experience.

Most babies born preterm have breathing problems shortly after birth, and many need help with their breathing. Clinicians have many treatments to help preterm babies breath, and know which treatments works best for most babies. But clinicians don’t know which treatments will work best for each baby. The BLUEPRINT Study aims to provide a more precise picture (phenotype) of how a specific preterm baby’s lungs are working in the first 7 days after birth. This will be achieved by combining information on the clinical care being used, measurements of lung function and the pattern of proteins in the blood collected 3 and 7 days after birth. We will then follow babies through until 2 years of age to measure their lung growth and function. By understanding the different lung phenotypes that exist in preterm babies, we hope to help doctors know which treatments may be best for a baby and predict which baby might be at more risk for lung problems as they grow up.

This study aims to evaluate the implementation of an evidence-based, multi-component intervention that improves the metabolic health and wellbeing of Aboriginal and Torres Strait Islander women before, during and after a pregnancy complicated by diabetes. The intervention consists of co-designed strategies, informed by previous research. The implementation will continue to use participatory approaches (co-design), with participants monitoring progress and collaborating to enhance sustainability. The mixed-methods evaluation of the implementation will: a) Explore the impact of the multi-component intervention on the metabolic health and wellbeing of participants at the study sites; b) Explore the impact of the multi-component intervention on the study sites (communities/services) as health promoting environments; c) Determine the acceptability and sustainability of the multi-component intervention at the study sites; d) Identify the enablers and barriers to implementation of the multi-component intervention.

This is a Phase 1, first-in-human (FIH), randomised, double-blind, placebo controlled study to evaluate the safety, tolerability, and pharmacokinetics (PK) of single ascending doses (SAD) and multiple ascending doses (MAD) of SION-451 administered as an oral suspension in healthy participants.

This is a Phase 1 study to evaluate the effect of food on the PK of SION-451 and the bioequivalence of a tablet formulation compared with the oral suspension formulation in healthy participants.

This is a prospective study to assess signal parameters of the Bonsai Sensor across different builds or design iterations of the device. Up to 60 participants will be recruitment to achieve total of 300 nights of recordings for each sub-study. Participants with or without diagnosis of Obstructive Sleep Apnoea will be screened and enrolled.

This purpose of this study is to examine whether new brain training regimes (active interventions) can influence brain function and reduce persistent post-concussion symptoms. This study will compare two different types of brain training to the “standard treatment”, which for mTBI is no treatment other than symptom management (control with no intervention). This will aid in determining whether people in the brain training groups have less symptoms because of brain training, or whether they would have had a reduction in symptoms anyway during that time.