ANZCTR search results

The purpose of this study is to determine the effect of protein-supplementation on faecal hydrogen sulphide production in healthy adult males. We hypothesise that protein supplementation will altern the colonic microbial environment but be safe, tolerable and adhered to by healthy adult males.

There has been previous reports that changes in sleep following exercise (either positive or negative) have been attributed to changes in core temperature, however, no studies to date have examine the effect of active (exercise) or passive heating on sleep quantity or quality. 12 participants will be recruited to complete three trials in a randomised order followed by sleep assessments (total sleep time, wake after sleep onset, sleep efficiency, sleep latency and sleep staging) using Actigraphy and Polysomnography and core temperature using an ingestible capsule. It is hypothesised that there will be a significant relationship with core temperature and sleep quality and changes in sleep staging.

Primary purpose: To compare the effectiveness of the two implementation strategies (PICOT versus in-person training) on the implementation of StressModex in routine physiotherapy practice. Secondary purpose: To evaluate the effectiveness of the two implementation strategies on patient health outcomes. Third purpose: To assess the cost-effectiveness of the two implementation strategies We hypothesise that (1) physiotherapists who receive the PICOT implementation strategy will be more likely to deliver StressModex to their patients with musculoskeletal spinal (neck and/or back) pain following non-catastrophic road traffic crash (measured by reach, adoption, dose, fidelity and sustainability of StressModex) compared to physiotherapists who receive usual in-person training; (2) patients of physiotherapy clinics participating in PICOT will have better health outcomes; and (3) the PICOT implementation strategy will be cost-effective compared to usual in-person training.

Using chilled saline as a medium for Coblation has been shown to reduce post-operative pain in both paediatric and adult extracapsular tonsillectomy. Its effect on the more minimally invasive intracapsular tonsillectomy (ICT) is unknown. A double-blind randomised controlled trial was performed to identify the effect of chilled saline on operation length, intra/post-operative bleeding, post-operative pain and return to normal activity in paediatric Coblation ICT.

Clinical trial examining implementation outcomes (acceptability, adoption, appropriateness, feasibility, fidelity, implementation costs) and clinical outcomes of an intervention, delivered within a concussion clinic model. The trial will offer an innovative, integrated stepped-care model that provides individualised, evidence-based intervention and continuity of care for children and adolescents following the initial assessment and diagnosis of concussion in Emergency or Primary Care settings. Concussion Essentials is a proven effective intervention for treating concussion symptoms and can be implemented in routine clinical practice.

Fear of dental pain can produce anxiety and contribute to dental phobia. Recently, alternative methods for producing effective anaesthesia that reduce the pain experienced during dental procedures have been investigated. One such method is Photobiomodulation (PBM) which uses light to transiently block nerve transmission of pain. Clinical trials have shown that some lasers can generate analgesia using PBM. Therefore, the purpose of this study is to investigate whether a polychromatic light emitting diode (LED) device (Nuralyte®, Dentroid Canberra, Australia) can produce pulpal analgesia for hypersensitive teeth during supragingival debridements. It is hypothesised that the multiwavelength LED device (Nuralyte®, Dentroid Canberra, Australia) will be more effective when comparing the active light source to sham irradiation (single blinding for the participants). This study is being completed as part of Dr Jessica Zachar's Doctor of Philosophy (PhD) program at The University of Queensland.

Fear of dental anaesthetic injection can produce anxiety and contribute to dental phobia. Recently, alternative methods for producing effective anaesthesia that reduce the pain experienced during dental procedures have been investigated. One such method is Photobiomodulation (PBM) which uses light to transiently block nerve transmission of pain. Clinical trials have shown that some lasers can generate analgesia using PBM. Therefore, the purpose of this study is to investigate whether a polychromatic light emitting diode (LED) device (Nuralyte®, Dentroid Canberra, Australia) can produce pulpal analgesia for dental restorations when compared with traditional dental local anaesthesia. It is hypothesised that the multiwavelength LED device (Nuralyte®, Dentroid Canberra, Australia) will be more effective when compared with traditional dental local anaesthesia. This study is being completed as part of Dr Jessica Zachar's Doctor of Philosophy (PhD) program at The University of Queensland.

This study aims to characterise the demographic and methamphetamine use profile of individuals downloading the S-Check 2.0 app, and examine associations between participant characteristics, app usage, and outcomes. Study results will inform future research and hybrid treatment options by improving understanding the characteristics of individuals that use a smartphone app as a resource for their methamphetamine use, and providing insights on how app usage is associated with changes in methamphetamine use and professional help-seeking.

This study evaluates the feasibility, acceptability, and pilot efficacy of the ONERO High-Intensity Resistance and Training (HiRIT) program in improving bone health, muscle strength and overall physical function in people with Multiple Sclerosis (MS). Total enrolment period is for 24 months. In the first 12 months, participants will be randomly allocated to the intervention group, who will attend the ONERO HiRIT program twice-weekly, or the control group, who will attend usual healthcare practices. In the second 12 months, the intervention group will be offered to continue the ONERO HiRIT program (at a cost subsidised by NDIS/Aged Care Packages or self-funding), and the control group will be able to join the program at no cost (equity between groups). The primary outcomes include changes in areal bone mineral density (aBMD) health-related quality of life (HR-QoL), while secondary outcomes assess physical function, mood (depression, anxiety) and cognition. Sustainability and acceptability will be measured using a health utilisation economic analysis and self-reported questionnaires. The findings will help support the use of the ONERO HiRIT program for people with MS within different healthcare settings.

This study aimed to conduct a pilot trial evaluating the impact of adding the Stay Strong app (SSA) to mental health and wellbeing services for Indigenous women and men in custody. The trial compared Immediate and three month Delayed use of the app by the health service, assessing its effects on wellbeing, empowerment and psychological distress at three and six months post-Baseline.