ANZCTR search results

The purpose of this study is to investigate whether a short injection of a drug called bevacizumab into the abdominal cavity (known as intraperitoneal infusion) after drainage of excess fluid in the abdomen may delay the return of the ascites compared to an injection of saline only. Who is it for? You may be eligible for this study if you are an adult with symptomatic, cytologically confirmed malignant ascites arising from a solid organ malignancy, excluding pancreatic cancer. In addition, you are either not receiving or not planned to receive additional systemic anticancer treatment for the duration of study treatment. Study details Participants will be randomly allocated to either receive bevacizumab with saline, or saline alone, into the abdominal cavity through an intraperitoneal infusion. This will be followed by a larger infusion of saline over a 30-60 minute period. This therapeutic drainage process may be repeated for re-accumulation of ascites during the study period, if required. Data from participant electronic medical records and quality of life questionnaires will be collected. It is hoped that this research will help demonstrate the potential activity of bevacizumab to decrease or delay the re-accumulation of malignant ascites.

Agitation commonly occurs on emergence from general anaesthesia in adult patients. Our hypothesis is that an orientation message and verbal command will be superior to a verbal command alone. The messages will be delivered via noise-cancelling headphones from cessation of general anaesthesia until the patient opens their eyes.

We are conducting a research study to better understand sleep and mental wellbeing in athletes. Sleep is an essential part of successful training and peak athlete performance. Good quality and adequate sleep are also important to support good mental health and wellbeing. There is not much information about sleep interventions to enhance sleep quality and quantity in elite/pre-elite athletes. Nor is there much information about the way that sleep affects mental health in elite/pre-elite athletes. The aim of this study is to learn more about whether a Cognitive Behavioural Therapy for Insomnia (CBT-I) sleep intervention protocol can improve sleep and mental wellbeing in athletes. We hypothesise that CBT-I will be efficacious for improving sleep quality in healthy athletes.

Exercise induced stress is common amongst many activities within health care, security, industry and sport. It has consistently been associated with increased inflammation, gastrointestinal disturbances, gastrointestinal symptoms and loss of appetite, resulting in an inability to maintain work-output and/or withdrawal from activity; constituting both a productivity and financial burden. The mechanism responsible for exercise-induced inflammation, and gastrointestinal symptoms appears to be multi-factorial in origin, but ultimately leads to gut surface damage and leakage, and an overall reduction in food and fluid intake. Increased gut leakage during exercise has also previously been linked to subclinical symptoms, heat illnesses, and other clinical manifestations such as exercise-associated bacteraemia. PRSE is a polyphenol-rich extract of sugarcane molasses. Polyphenols are naturally occurring substances in plants, known for their potential health benefits. We will explore the ability of PRSE to reduce exercise-associated gastrointestinal disturbances, including symptomology.

Chronic obstructive pulmonary disease (COPD) is an incurable and progressive lung disease that causes millions of deaths annually worldwide. Intervention in the pre-COPD stage (before COPD diagnosis but when lung damage has begun) may help prevent progression to COPD. Household air pollution (HAP) may worsen respiratory health. We will conduct a feasibility RCT on the use of HEPA air filters to reduce HAP for people with pre-COPD. Our results will inform future, larger research trials.

This is a randomised controlled trial (highest quality evidence) aimed at comparing a newer technique in oxygen delivery (high flow nasal oxygen) to current industry standard technique (face mask oxygen). The study design simulates conditions immediately before the start of a general anaesthetic to test a crucial safety step called preoxygenation. The specific population we are studying are obese, pregnant people who are in late pregnancy (more than 36 weeks). This group is at a high risk of oxygen problems after the start of a general anaesthetic which makes preoxygenation additionally important. Our hypothesis is that high flow nasal oxygen is not worse than face mask oxygen for preoxygenation in this patient group. The results will inform anaesthetic practice for this high risk patient group.

This study aims to evaluate Empower: Body Acceptance Skills, a group program designed to target body image and well-being in adults with a chronic illness. Who is it for? Adults living in the ACT and surrounds who have been diagnosed by a medical practitioner with chronic physical illness may be eligible to participate in this program in the ANU Psychology Clinic. Study details Participants will attend 8 sessions of cognitive behavioural therapy in small groups of up to 8 members. These sessions will discuss various aspects of body image and provide skills training for body image and wellbeing. Participants will be asked to fill in questionnaires evaluating the impact of the intervention, as well as its feasibility and acceptability. It is hoped that findings from this study will help inform future iterations of this program to improve body image and well-being in adults with a chronic illness.

This primary aim of this study is to assess, in individuals with amnestic mild cognitive impairment, if facilitated progression towards (or meeting of) Biochemical & Physiological Targets, through participation in a 6-month personalised multimodal lifestyle Intervention will, in comparison to standard care (Control Group), cause significant improvements in cognition

Gum disease is a very common oral disease that, if not treated, may cause tooth loss. The disease is caused by bacteria that build deposits on your teeth, above and below your gums. These are known as dental plaque and these may mineralise forming dental calculus (or tartar) on tooth surfaces. Management of gum disease requires an adequate level of self-performed teeth cleaning as well as professional intervention aimed at removing dental plaque and calculus. Although this treatment is effective for most teeth, challenges arise in the management of teeth that have multiple roots, such as molars. When gum disease has progressed to involve these teeth they can be harder to maintain long term. Air polishing is a treatment modality approved by the Australian Federal Government (TGA approved) and currently used in dental treatment. AIR-FLOW®’ is a specialized device that generates a spray of air, water and powder to aid in plaque removal without additional patient discomfort. This study aims to focus on its use on maintaining molar teeth with gum disease. The research has 3 main goals 1. Identify the impact of treatments on health/stability of gums around molar teeth. 2. Identifying the impact of treatments on the level of specific bacteria around molar teeth. 3. Determining how gum disease affects quality of life. It is anticipated that the air polishing will assist in reducing the level of specific bacteria around molar teeth and provide additional improvement in the stability of gum health.

The purpose and aims of this clinical quality registry are to monitor emergency care processes and outcomes through the provision of timely extraction and analysis of ED clinical data.