ANZCTR search results

Does the use of Music Therapy or Combination of music therapy with sucrose (24 % sterile sugar water) provide similar or better pain relief compared to Sucrose during the heel prick procedure. The research is aimmed to see if we can reduce the usage of sucrose, especially repeated and higher dosages in NICU with the help of music therapy which is relatively safe (within the recommened sound dose levels) and developementally appropriate intervention.

The Parenting Kit, titled “Growing together”, has been designed to guide prospective and new parents from conception until their child is one year of age. . The idea is that the kit is generic, with the aim being that if effective it will be able to be rolled out throughout Victoria. A team from Judith Lumley Centre at La Trobe University are conducting a cluster RCT to evaluate the Parenting Kit. The two arms of the trial will consist of a control group receiving standard care and intervention group receiving the Parenting Kit. Various outcomes will be measured including maternal health and well-being, women’s experience of motherhood, attachment, infant development, and parental confidence. The views and experiences of health professionals will also be evaluated.

This clinical trial outlines the design of a randomised controlled trial that investigates the potential benefits of adding a widely available and inexpensive intervention to standard Multimodal Manual Therapy (MMT). Numerous chronic low back pain (LBP) Clinical Practice Guidelines have recommended that patient management for LBP should consist of MMT and cognitive behavioural therapy (CBT). MMT and CBT are effective interventions for LBP as standalone treatments. Furthermore; they have the potential to be combined as a secondary intervention for prevention of LBP related disability. It is also known that higher levels of patient self-efficacy correlate with improvements in disability. CBT is known for its effects on improving self-efficacy. The primary aim of this trial is to assess the effects of combining MMT with MoodGYM on self-efficacy and disability . This study is the first to investigate the secondary prevention of problems in a chronic LBP population using this combined intervention approach. If this approach shows signs of being effective in reducing long-term disability, it will allow patients, practitioners and other stakeholders who don’t have access to a multidisciplinary team, access to a best practice care tool for the management and secondary prevention of chronic LBP. Furthermore, the outcomes of this trial may produce the beginnings of a tailored interner-based CBT program that can be added to MMT for patients that are at medium risk of developing LBP related disability and pain.

This study aims to determine whether the smartphone applications for skin screening are effective at providing an accurate diagnosis of melanoma. Who is it for? You may be eligible to join this study if you are aged 18 years or above and have a suspected melanoma and/or clinically benign skin lesion. Study details. The accuracy of smartphone applications will be tested by taking photos of the skin lesions and comparing the smartphone applications evaluation against the histological gold standard diagnosis by a dermatologist. If the study shows that these applications are accurate, this will allow greater acceptance of them for medical use. If inaccurate, it will raise concerns about the need for regulation of these applications due to the health risk posed.

This research project is being conducted to look at how safe and well tolerated a new drug called DUR-928 is when given to healthy volunteers, once daily for 5 days at 2 different dose levels. The pharmacokinetics of DUR-928 will also be studied; this is done by measuring the amount of DUR-928 in the blood at different times throughout the 5 day dosing period, allowing us to evaluate how DUR-928 is handled by the body (for example how quickly it gets into the blood stream). This study will also look at the effect the food may have of the pharmacokinetics of DUR-928.

This study will investigate the effectiveness of using either radiotherapy or Imiquimod to treat lentigo maligna (LM), when surgery is not possible, is refused, or fails. Who is it for? You may be eligible to join this study if you are aged 18 years or above and have a biopsy proven LM. Study details: Surgery is the standard treatment for people diagnosed with LM. However for some people, it may not be possible due to the location of their LM lesion(s). Currently, the Australian and New Zealand Melanoma Treatment Guidelines recommend radiotherapy for the treatment of LM however there is no clinical trial evidence for this and a trial is needed to prove which treatment is safer and more effective. Some clinicians may also recommend the use of a cream called Imiquimod. Although not currently licensed for treatment use in LM, there is some evidence to suggest that it is both safe and effective in treating LM. Participants in this study will be randomly (by chance) allocated to either standard care radiotherapy or 12 weeks of treatment with imiquimod cream 5 times a week. All participants will be followed up to 24 months and attend regular visits with their study doctor to monitor side effects and treatment response.

Parental psychopathology is a commonly accepted risk factor in the development of childhood disorders. The heritability of internalizing disorders, in particular, has been well established in family aggregation studies of both the offspring of anxious parents as well as the parents of anxious offspring (for a review see Drake & Ginsburg, 2012). In contrast to the abundance of studies exploring parental and child psychopathology, the area of parental and child resilience is heavily under-explored. With resilience increasingly becoming recognised as a lifelong process, interventions targeting adult populations provide the potential for benefiting both the individuals completing the program as well as their families. The proposed study aims to explore whether a conjunctive parent resilience intervention improves outcomes for children completing the FRIENDS program.

Currently, standard practice for any snake bite requires laboratory testing to determine if a patient has been envenomed, and coagulation studies are the most important tests. The administration of antivenom is then based on the presence of clinical effects of envenoming and abnormal laboratory investigations. However, many of these envenoming effects are irreversible, so once they develop they are unlikely to be reversed by antivenom. In this case, antivenom needs to be given prior to the development of abnormal laboratory test or clinical effects. The aim of this project will be to administer antivenom early – as soon as the patient presents to hospital, without first waiting for laboratory tests or the development of clinical signs of envenoming, and/or retrieval to a major hospital. The objective is to prevent envenoming effects that may lead to significant morbidity or death.

This clinical study is a prospective, randomised, multi-centre study that will enrol 144 patients over a 12-month recruitment period between three surgeons and three centres. The objective of the study is to investigate if the Mathys RM Pressfit Cementless Cup maintains acetabular bone stock by reducing the effects of stress shielding when compared with a conventional rigid cementless acetabular cup. This study also aims to demonstrate safety, and equivalent clinical outcomes to standard care. The RM Pressfit Cementless cup is designed to have a modulus of elasticity that is similar to bone, and therefore it may be possible to transfer physiological loads through the cup and prevent the bone behind the cup from resorbing due to stress shielding. The control group for this study will be a standard hip replacement with a conventional rigid cementless acetabular cup. Standard, functional parameters will be assessed pre-operatively, and post-operatively at 6 weeks, 6 months, 12 months, 2 years and 5 years. Antero-posterior and lateral radiographs will be analysed at 6 weeks, 1 year and 5 years to assess femoral stem and acetabular cup orientation. DEXA (measures bone density) scans will be assessed pre-operatively at 6 weeks, 6 months, 12 months, 2 years and 5 years to measure acetabular bone density, with the aim of showing preservation of bone behind the RM Pressfit Cup when compared to a conventional rigid cup.

An observational trial to determine the usefulness of the Leicester Cough Questionnaire and a short symptoms assessment tool (Respiratory Symptoms in Cystic Fibrosis) in people with cystic fibrosis.