ANZCTR search results

This study aims to evaluate the effects of a brief, individually-tailored web-based parenting program on parenting behaviours associated with adolescent depression and anxiety disorders. The program is designed to provide parents with personalised feedback about their current parenting, including what they are doing well and areas that they can improve in order to reduce their teenager’s risk of depression and anxiety. We aim to find out whether this program can help improve parenting behaviours associated with adolescent depression and anxiety, and in turn reduce risk of depression and anxiety in teenagers.

There is an increased awareness in the medical community about the role of diet to prevent and treat cardiovascular disease, diabetes and obesity. This study will examine two different eating patterns and assess their effect on risk factors for cardiovascular disease, diabetes and obesity. The study comprises a 4-week dietary intervention, with data collection occurring at the beginning and again at the end of the 4-week period. We will be comparing the differences in results between the two dietary patterns. This will help us formulate the best dietary pattern to use for future studies, and also to assist the wider community in the treatment and prevention of cardiovascular disease, diabetes and obesity.

This study aims to investigate the development of preterm breastfeeding skills and the impact of bottle-feeding teats, nipple shields and degree of breast fullness on the achievement of full oral feeding. As mothers are unable to be in the neonatal nursery for all of their infant’s suck feeds, bottle feeds are required occasionally. There is evidence that an intraoral vacuum-triggered teat (Calmita, Medela AG) encourages a sucking action similar to breastfeeding and reduces the length of hospital stay and formula use at discharge compared to a conventional teat. We wish to examine the effects of different teats and breastfeeding support on feeding outcomes. Objectives: 1. To track over time the maturation of intraoral vacuum, coordination of sucking, swallowing and breathing, and maintenance of a normal heart rate and oxygen saturation during feeding, and to determine if this is related to increased breastfeeding effectiveness and efficiency. 2. To explore the effect of the amount of milk available in the breast on the volume of milk transferred during breastfeeding at 34 weeks corrected gestational age (CGA). 3. To explore the use of a nipple shield on the volume of milk transferred at 35 weeks CGA. 4. To compare suck-swallow-breathe coordination during breastfeeding with that during bottle feeding with Calmita, and bottle-feeding with a conventional teat. 5. To determine the effect of a vacuum triggered teat on timing of achievement of full breastfeeding and on breastfeeding duration

This study will examine the links between melanoma risk and the genetics controlling skin, hair and eye colour and mole type and distribution. Who is it for? You may be eligible to join this study if you are a resident of southeast Queensland or northern NSW who is able to attend an appointment at the Princess Alexandra Hospital and who has had a melanoma (group 1) or who has not had a melanoma (group 2). People of any age are eligible. Study details All participants in this study will attend a one-off appointment where they will fill out a questionnaire about their sun exposure and medical history and give a saliva sample for DNA testing. A research assistant will record the participant's skin, hair and eye colour, weight and height and take full body images of the participant in their underwear as well as dermoscopic (close-up) images of moles larger than 5mm in diameter. This usually takes between 1 and 2 hours. We hope that this research will contribute to better melanoma screening procedures and identify people who would benefit from more frequent skin checks.

Polycystic ovary syndrome (PCOS) is a major public health concern affecting one in five young Australian women and costs the country $800 million/y. It has significant metabolic [diabetes (T2DM) and adverse cardiovascular risk factors (CVRF)] and reproductive [sub-fertility and menstrual disturbance] consequences that are underpinned by insulin resistance (IR) and exacerbated by obesity. Despite the successful work of our group and others, gaps remain in understanding the mechanisms of IR in PCOS and in determining optimal therapies – including exercise interventions. We will advance understanding of the biological origins of PCOS, and of optimal therapies. Using gold-standard measures of insulin sensitivity and advanced molecular techniques we will significantly advance knowledge on mechanisms of IR in PCOS including ectopic lipid accumulation, tissue fibrosis, and epigenetics and the impact of exercise in a randomised control trial. We will recruit 60 over weight women with PCOS and compare the benefits and impact of high-intensity intermittent training (HIIT), with standard exercise recommendations or lifestyle advice. The impact of HIIT on these mechanisms will be elucidated, clarifying its value as an effective lifestyle intervention. This work will reveal mechanisms of IR and impact of exercise in PCOS, uncover potential therapeutic targets for IR in PCOS and obesity and inform optimal exercise prescription for lifestyle therapy.

A randomised controlled trial will be conducted, using the online Writing for Health program, to examine the efficacy of Internet-based writing exercises focusing on benefit-finding in diabetes, versus an active control condition, in reducing diabetes distress and increasing perceived benefits of living with diabetes (primary outcomes) and reducing symptoms of depression and anxiety and increasing diabetes self-care and self-reported general health (secondary outomes). Adults with type 1 or type 2 diabetes visiting the Writing for Health website, in response to advertisements, will be invited to participate in the study. Following informed consent and an online screening procedure, participants will be randomly allocated to one of two interventions: i) Benefit-finding: Writing about any positive thoughts of feelings about experiences with diabetes; or ii) Use of time: Writing about how time has been spent this day and will be spent next week. Both interventions in the Writing for Health program involve writing online for 15 minutes once a day, for three consecutive days. Participants will complete online questionnaires at pre-intervention, during the program, post-intervention, and at one and three month follow-ups.

The purpose of this investigation was to determine the effect of compression garments on performance and vertical stiffness during single-leg-hopping to exhaustion. The alternate hypothesis was that compression garments would lead to a change in the duration of single-leg hopping and leg mechanical characteristics.

We hypothesize that giving oral probiotics to pregnant women during later part of pregnancy (>23weeks) will reduce GBS colonization at 35-37 weeks. This will thereby reduce the need of intrapartum antibiotics for women and infection blood tests for the babies. We also hypothesize that this will have additional beneficial effects on obstetric (GDM, preeclampsia, maternal infections), perinatal (premature rupture of membranes, preterm births) and neonatal outcomes (including reduction in neonatal sepsis).

Diagnosing neonatal infection, whether early or late , can be challenging as there is no one ‘gold standard’ test (Srinivansan and Harris, 2012). Failure to diagnose infection in the newborn infant in a timely manner can lead to higher death and illness rates (Carcillo, 2006). Continued surveillance to monitor changes in the infants condition is also paramount to distinguish between infants with an infection and non-infected infants. One way, which may help in the diagnosis of infection in the newborn premature infant is by measuring the body temperature and the skin temperature of the foot, on a continuous basis.All babies who are born at or before 32 weeks gestation are eligible for the study. If you have given consent for your baby to be part of this study your baby will have temperature measured by a small probe, which is placed on the sole of the foot, a small thermometer which is incorporated into the gastric tube ( all infants born and admitted to the neonatal unit will have one of these placed). This tube is mainly used for two things, to vent the stomach to prevent build up of gas and to feed baby when ready. Your baby will also have a temperature which is measured under the arm. We will collect information from your baby’s notes and observation charts. Information which will be recorded and used in the study will be gender, antenatal history, birth score , gestational age, birth weight, temperature, blood test results and type of environment your baby is nursed in.

Electromagnetic Millimetre Wave Therapy (EMT), originally developed in Russia, has shown promise in pain relief therapy in several randomised controlled trials conducted in the USA and Europe in the last 15 years. EMT was shown to be effective in reducing painful conditions, including joint pain, headache, postoperative pain, and neuropathic pain. Aims of this study In this study, we want to find out: 1. The effect of EMT on pain relief 2. The effect of EMT on pain related quality of life 3. The duration of pain relief by EMT 4. The tolerability of EMT The proposed study will be a preliminary investigation of the effectiveness of EMT in pain relief. Data will inform the proposal for a larger cohort study. Patients, presenting with chronic pain and attending the NIIM clinic, will be approached to participate. Pain levels and locations will be variable, in this pilot phase. Consenting patients will be treated with EMT therapy for 15 minutes. Subjective pain levels, and the impact on the quality of life will be assessed at baseline, shortly after EMT treatment, and at regular intervals for three days after the clinical session, using validated pain scales.