ANZCTR search results

The primary purpose of this study is to define the PK profile of the Maxigesic oral suspension plus the clinical efficacy and safety of the high dose and low dose groups. The other purpose of the study is to define the concentration-response relationship for the high dose and low dose of Maxigesic oral suspension

This study will evaluate the usability, acceptability and impact of the Keep It Real website for young cannabis users with psychotic-like experiences (PLEs). Participants will be asked to evaluate a new website about cannabis use and psychotic-like experiences (PLEs). This evaluation will determine the impact of the 'Keep it Real' website on PLEs and cannabis use in young people. 180 participants will be given 6 months' access to the website. Half of these participants will comprise a waitlist control, whose access to the website will be delayed by one month. They will complete an online survey at 1, 2, 3, and 6 months' follow up. This will assess outcomes such as PLEs, cannabis use, psychological distress and functioning. Information will be collected about the number of times the website was used; the date, time and duration of each session; the sections of the website accessed and data entered.

In many cases, an IVF cycle can result in many embryos of good quality. In Australia, Single Embryo Transfer (SET) is preferred and therefore remaining embryos are either discarded or undergo vitrification, which is a process of rapidly cooling embryos, and stored at -196°C. The embryo vitrification protocol causes rapid changes in temperature which can cause instability in some embryos and result in a failure to survive the thaw process, with approximately 1 in 10 embryos failing doing so. It is proposed that in order for an embryo to survive vitrification, it needs to “collapse” from its expanded state, to a compact group of cells. In its collapsed state the embryo is thought to be protected. Around the world, fertility clinics are changing vitrification protocols to include assisted or artificial collapse of the embryo prior to vitrification. This has resulted in many clinics demonstrating significant improvements in both the number of embryos surviving vitrification and pregnancy outcomes. We plan to compare our normal vitrification protocol with this new method of artificial collapse prior to of normal vitrification protocol, to see if we can improve both embryo survival and pregnancy outcomes.

This is a pilot study assessing the useability of a kit designed to assist re-intubation in patients with a difficult airway. 30 patients presenting for elective surgery will be intubated using the Cook Staged Extubation Set. A difficult airway will be simulated by releasing pressure on the laryngoscope to obtain a grade 3 view. The procedure will be timed and evaluated for difficulty by the intubator.

This study aims to investigate whether ongoing treatment with prednisolone and dexamethasone can supress multiple myeloma as post-autograft maintenance therapy. Who is it for? You may be eligible to join this study if you are aged 18 years or above and have received lenalidomide maintenance as part of the LEOPARD study as immediate therapy prior to relapse or progressive disease. Study details. All participants in this study will receive a therapy consisting of Pomalidomide and Dexamethasone. Both will be taken orally at a 28 day cycle, Pomalidomide at a dose of 4mg (starting dose) daily from Days 1 to 21, and Dexamethasone at a dose of 40mg (starting dose) weekly on Days 1, 8, 15, 22. Blood tests will be taken every cycle (28 days) to assess safety, tolerability and efficacy of the treatment. A bone marrow biopsy will be performed at the beginning of the study and whole body x-ray will be taken at the beginning and end of the study. Participants will be followed-up until they complete the study to determine response rates, survival and safety and toxicity of the this treatment.

The aim of this pilot study is to test the procedures for a larger trial that will compare two different tools (partographs) for measuring progress in labour. In particular we aim to achieve a compliance rate of 85% with both the intervention and control arms of the trial. The outcomes will inform any necessary changes to the main study protocol. If no substantial changes are required the data from this pilot study will be incorporated into the results of the main study

The aim of this study is to report the effects of a Game Centered Approach professional development program for improving game play abilities, active learning time, athlete enjoyment of training, athlete physical self-perception and athlete perceived motivational climate. The Professional Learning for Understanding Games Education in Sport (PLUNGE into SPORT) program was developed to enhance the coaching skills of community sport based volunteer coaches using a Game Centered Approach in an authentic learning environment. We hypothesized that athletes in the PLUNGE intervention, compared to those in the control group, will display more favorable changes in game play abilities, activity levels during sessions, enjoyment of training, physical self-perception and perceived motivational climate.

Previous research has found that abdominal muscle activation is greater when core stability exercises are performed on unstable surfaces compared with stable surfaces. The foam roller is one apparatus commonly used to create instability in a transverse plane while performing floor-based exercises to improve abdominal muscle activation. The Oov (http://www.oov.com.au/) is a newly designed apparatus intended to assist the individual in maintaining a neutral spine, whilst also creating instability in both the transverse and sagittal planes; allowing the individual to perform core-strengthening exercises, stretches and mobility activities with correct spinal posture. In comparison to the foam roller, which is unstable in only 1 anatomical plane, the Oov is unstable in two anatomical planes. This increased instability may create greater activation of the trunk muscles, but no research into muscle activation while using the Oov has been conducted. Each participant will perform three tasks: crook-lying (CL), single leg tabletop (TT) and straight leg raise (SLR). These tasks will be performed on a Pilates Trapeze Table under three different surface conditions: flat, foam roller and oov.

This study examines the safety and tolerability of Progenza, a stem cell product derived from a single donor, for the treatment of knee osteoarthritis. Progenza is injected once into the knee. There is a 1 in 5 chance of receiving placebo, which contains no stem cells. The study will investigate the effect of Progenza on knee pain, function and cartilage integrity. Quality of life and activity level will also be examined over the course of the study.

The rationale of the study is to evaluate the efficacy of enhanced monitoring and referral to specialist services as a means of reducing PTSD after traumatic injury. This study compares the relative effectiveness of (a) Enhanced Monitoring and Referral, and (b) Treatment as Usual in reducing posttraumatic stress disorder symptoms. It is hypothesised that Enhanced Monitoring and will lead to greater symptom reduction than Treatment as Usual.