ANZCTR search results

This project aims to investigate (1) the effectiveness of the HELFIMED protocol for improving dietary behaviours and nutrition status of people with self-reported depression; (2) the mental health benefits of improved diet/nutrition status and (3) the cardiometabolic benefits of improved diet/nutrition status.

Most children born in the Western world have a sibling. Of all the aspects of the sibling relationship, none is potentially more harmful than sibling conflict. Of particular concern, the impact of pervasive sibling conflict is potentially devastating and far reaching for children and their parents’ social, emotional and behavioural health. This study aims to evaluate the efficacy of a brief, group-based parenting intervention for parents of children experiencing sibling conflict. It is expected that participating in a group based parenting intervention has the potential to reduce rates of sibling conflict, increase warmth in the sibling relationship and lower rates of ineffective and coercive parenting practices.

The project will aim to test a single-session parenting group for parents of children with problem eating. It will add observational data to a trial conducted in 2012. It is anticipated that the group will improve child feeding, the strategies parent use at mealtimes, and how parents think and feel about mealtimes. The study will also seek to identify which types of feeding problems respond best to this intervention.

The aim of this research is to investigate a behavioural treatment for the management of headache triggers within a cognitive-behavioural therapy program. The research will compare two variations of trigger management, one being the traditional approach (avoidance of all triggers) and one being a variation of the traditional approach (learning to cope with triggers). The investigators hypothesise that the enhanced approach which assists individuals to manage triggers rather than simply avoid them will have more positive outcomes including reduced headache frequency, reduced use of pain medication and improved quality of life

Title Optimising Peritoneal Dialysis: A Comparison of Adapted and Conventional Peritoneal Dialysis Objectives To investigate the effect of varying the dwell time and fill volume of peritoneal dialysis to determine whether a new dialysis regime (Adapted Peritoneal Dialysis) offers better fluid removal and solute clearance than conventional peritoneal dialysis in patients maintained on chronic peritoneal dialysis. Patient Impact Patients maintained on peritoneal dialysis are routinely seen in clinic with a blood test, clinical review and a review of their dialysis parameters and prescription every 2-4 weeks. Participation in this study will require a clinic review every 2 weeks. Therefore at most, participation will involve 3 extra visits with one extra blood test, usually taken via finger prick. For the majority of patients there will be no extra appointments required. The protocol for the study has been drawn up in consultation with dialysis-nurse co-ordinators and one parent whose child is on nightly peritoneal dialysis.

There is evidence in the published literature that consumption of a high fructose diet is detrimental to cardio-metabolic health. The purpose of this research is to determine the effect of dietary fructose consumption on plasma lipids, satiety hormones, insulin resistance and inflammation. If our hypothesis is validated, dietary strategies can be designed to reduce body weight and associated risk for the development of diabetes and cardiovascular disease

Approximately 220-250 mg of iron is lost with each 470 mL whole blood donation. This may result in progressive iron deficiency, ultimately leading to iron deficiency anaemia and deferral at a subsequent attendance. This study will pilot an education program for high risk donors on how to replenish iron stores after donation. The study will evaluate operational feasibility, donor acceptance and efficacy of this program.

The proposed research aims to complete a comprehensive assessment of the physical health of Vietnam Veterans with and without posttraumatic stress disorder (PTSD) to improve the understanding of the illnesses associated with PTSD. Assessment of organ function in each group will be carried out to provide information regarding which conditions are associated with PTSD and how these relate and are inter-related. Mechanisms by which these proposed associations may be explained will be explored. This will include investigation of mechanisms which have been proposed as causing physical health damage in PTSD. These include dysregulation of the hypothalamic pituitary axis (HPA), chronic activation of the sympathetic nervous system and chronic inflammation. In addition, neurogenetic and epigenetic studies will be included to identify the genes and their genetic and epigenetic variants that contribute to the susceptibility to either PTSD or to physical damage associated with PTSD.

This is the first clinical trial of HSK3486 and will be conducted in healthy volunteers to determine the safety, tolerability (including pain on injection), and PK(only to be assessed for subjects who are randomized to HSK3486 in Cohorts 3 to 8)and PD and profiles of HSK3486 administered as a single IV injection. Results from this study will supports further clinical development of HSK3486. This study will be performed in compliance with the protocol, International Conference on Harmonization Good Clinical Practice (ICH GCP) and local regulatory requirements. Aspects of the study concerned with the investigational product will meet the requirements of Good Manufacturing Practice (GMP).

The purpose is to investigate whether interactive digital technology (using the Xbox Kinect system) is feasable to use to improve the volume of activity that stroke survivors can undertake, and to determine if there are benefits to upper limb function or mobility using this technology