ANZCTR search results

This project explores the viability to augment existing Exposure Response Prevention (ERP) treatment with Imagery Re-scripting (IR). Due to the aversive nature of ERP treatment, the authors postulate that the mastery of IR can help participants to foster confidence and improve adherence to in-vivo exposure exercises. Using a case-series methodology, four participants will take part in a 10-session, weekly therapy format. The IR-ERP treatment is hypothesized to bring about clinical improvements in terms of OCD symptoms, treatment adherence and general well-being such as depressive, anxiety, stress and self-efficacy.

The trial's main purpose is to test the effectiveness of platelet-rich plasma (PRP) injections in patients who have painful gluteal tendonopathies. The trial aims to see if PRP use in patients who have gluteal tendonopathies reduces pain and improves functional levels at 12 weeks follow-up, compared to cortisone injection. No data exist on the use of PRP in gluteal tendonopathies. A small, uncontrolled study carried out by the investigators showed promising results. Therefore we want to study the use of PRP injections in patients with gluteal tendonopathy prospectively, in a double-blind randomised, controlled trial.

This study will examine the relationship between anxiety and asthma. Children and their parents will complete assessments about their illness, anxiety and two experimental tasks as part of an assessment for treatment. Children and their parents will then be randomized to an eight session cognitive behavioural treatment (CBT) targeting anxiety amongst children with asthma and their parents. Following treatment, children will again complete the same assessments as prior to intervention. This project will be the first to evaluate the efficacy of CBT developed specifically for dealing with anxiety in children with asthma.

Patients with lifestyle limiting intermittent claudication will be offered, in addition to best medical therapy, participation in a 12-week supervised exercise program consisting of two 1 hour sessions per week. The exercise prescription will be based on current evidence of treadmill walking to near maximal pain. They will also undergo two key assessments at baseline (day 0) and at day 90. This will consist of measurement of walking performance (PFWD and 6MWD), body composition (DEXA), resting energy expenditure (calorimetry), endothelial function (FMD and EndoPAT), monocytes and subpopulations (flow cytometry), levels of apoptosis, lactadherin mRNA and protein expression and microRNA-92a expression in ischemic and non-ischemic muscles of the symptomatic leg.

With advanced ageing, physical and cognitive functions decline and these age-related changes increase the risk of falls. Above the age of 65 years, about one third of individuals experience at least one fall every year with about half of those who fall in this period do so multiple times. As stepping and specific cognitive functions are risk factors for falls in older people, this study aims at improving these functions to reduce risk. In this randomised controlled trial, participants will use low-cost computer game technology to play a range of games that combine stepping and specific cognitive functions. Earlier studies have shown that this intervention type and mode of delivery is feasible and safe. In this phase III trial, participants will be recommended to perform the exergames three or more times per week for 20 minutes for a period of three months. At the end of the trial, physical and cognitive functions associated with fall risk will be assessed. Falls will also be recorded over a period of six months. Using this novel approach of delivery, we hypothesize that playing exergames can improve both physical and cognitive functioning and reduce the risk of falls.

This is a single-centre study using a QIMR3D7Pf innoculum challenge to assess the infectivity of this recently collected isolate. The study will be a first in human study conducted in 2 participants. A sentinel volunteer will be dosed 24 h ahead of the remaining volunteer.

The purpose of the study was to evaluate the effectiveness of a family intervention, the Resourceful Adolescent Parent Program (RAP-P) in reducing adolescent suicidal behaviour and associated psychiatric symptoms. It was hypothesised that the RAP-P program would lead to significant improvements in suicidality, adolescent mental health, and family functioning.

Depression is one of the most common of all mental health problems and one in five people experience depression at some stage of their lives. A review by the National Institutes of Health found that some 20% of adolescents suffer from bouts of anxiety and depression before they reach adulthood. EFT (Emotional Freedom Techniques) has been shown to be efficacious for depression in a number of studies, including three randomized controlled trials. EFT contains elements of both exposure and cognitive therapy but to these established methods, adds the novel element of somatic stimulation. It has been found to have physiological mechanisms consistent with a lowering of the stress response, and a calming of the threat-assessment structures in the midbrain. These include a reduction in the body’s secretion of stress hormones such as cortisol, an increase in endogenous opioids, and a dampening of fear in the amygdala. This present study intends to compare the EFT treatment to a gold standard therapy for depression; Cognitive Behavioural Therapy (CBT), and a community control group. Understanding and improving the early intervention and treatment of depression and improving the health and quality of life for those with depression is critical to inform best practice. Hypotheses will include: 1. The EFT group treatment conditions will have significantly decreased scores on depression measures from pre- to post treatment, and will be significantly improved compared to the community control group 2. It is expected the CBT group will also have significantly decreased scores on depression measures from pre- to post treatment, and will be significantly improved compared to the community control group, but that the EFT condition may be superior

An unanswered issue relates to the use of Penthrox in clinical setting is its impact on psychomotor function and the ability to driving or operating complex tasks, as the lack of adverse psychomotor effects from Penthrox may allow patients to drive, and even return to work on the same day of the colonoscopy. Given colonoscopy is increasingly performed for screening and surveillance purposes, the ability to return home or work place without carers would carry significant cost benefit and minimize work disruption. Currently, there are no data on the impact of inhaled Penthrox, or methoxyflurane in general, on the psychomotor function in humans. The aim of this study is, therefore, to evaluate the effects of inhaled Penthrox on psychomotor functions of healthy volunteers as well as subjects who undergo colonoscopy with Penthrox. Hypothesis: Inhaled methoxyflurane has minimal sedative effect and thus, has minimal or no effect of psychomotor function in humans.

The study is evaluating and comparing the effects of aerobic-based versus resistance-based exercise to usual care on lymphoedema, lymphoedema-related symptoms (e.g. decreased fitness, impaired functioning, changes in weight, strength loss), and quality of life. Who is it for? You may be eligible to join this study if you are a female, aged 18 years to 70 years, with a diagnosis of unilateral breast cancer-related lymphoedema following nonmetastatic breast cancer, completed all cancer-related treatments, and physically capable of participating in a moderate-intensity exercise program. Trial details Participants in this study will be randomly (by chance) divided into one of three groups. Participants in one group will be allocated to a 12 week aerobic-based exercise intervention. Participants in the second group will be allocated to a 12-week resistance-based exercise intervention. Participants in the third group will be allocated to usual care, which will involves a weekly phone call to monitor physical activity levels and lymphoedema symptoms and treatment, as well as to maintain study interest. Following the 24-week intervention, this group will be offered a personalised exercise program. All participants, regardless of group allocation, will be assessed pre- and post-intervention and again at 12 weeks post-intervention. Participants will be required to complete some questionnaires and tests throughout the duration of the trial in order to evaluate the effects of aerobic-based exercise and resistance-based exercise on fitness level, weight changes, strength, function, self-efficacy, presence of lymphoedema and quality of life. The results of this trial will help gain a better understanding on whether participating in certain exercise types provides greater lymphoedema-related benefits over other types or usual care.