ANZCTR search results

These search results are from the Australian New Zealand Clinical Trials Registry (ANZCTR).

You can narrow down the results using the filters

31380 results sorted by trial registration date.
  • Appraisal of the LIFT and BioLIFT procedure: initial experience and short-term outcomes of patients with complex anal fistula.

    The surgical management of anal fistulas remains in an evolutionary phase. A new sphinctersaving technique known as the LIFT (ligation of intersphincteric tract) procedure has gained growing interest. Early results together with reports from other authors have been promising with 57-94% success and minimal complications. The use of a bioprosthetic device has been suggested to augment the LIFT procedure (BioLIFT). The purpose of this study is to evaluate and compare outcomes of patients where repair of transphincteric anal fistula was performed using LIFT and BioLIFT techniques. Patients who have undergone LIFT or BioLIFT procedure from 2011-current, by a single surgeon will be retrospectively reviewed. Case notes will be retrieved and data entry performed. Statistical analysis of outcomes will be assessed. Outcomes measures of complications, recurrence, physiology studies performed pre and post operative, will be evaluated.

  • A 12 month randomised controlled trial to determine biomarkers from the gut microbiota as management tools for overweight and obesity

    Microbes influence how much energy we extract from our diet, how we regulate the storage of this as fat, and also on glucose regulation. There are both good and bad microbes. We have found that in overweight or obese persons undergoing weight loss diets not everyone is successful and significantly those who fail to lose weight are also those who fail to change their microbial community composition. In this study we aim to identify microbial signals in stool samples that will allow clinicians to predict which diets will give successful weight loss outcomes (thus avoiding the frustration of diet failures) and also to test how to improve and change a person’s microbiota to a healthy composition.

  • A study to determine the effects of nutrient-containing pellets on the release of gut hormones, and blood glucose and appetite control, in patients with type 2 diabetes

    The purpose of the study is to determine the effects of enterically coated, nutrient-containing (CTM#3) pellets on glycaemic control, the release of gastrointestinal peptides, and sensations of appetite in patients with type 2 diabetes

  • The effect of fructose and high fat feeding on the regulation of hunger and satiety.

    The aim of this project is to determine the effects of fructose feeding on fat-induced weight gain in humans. The hypothesis is that the satiety effect will be greater in those consuming a high fat meal with fructose as oppose to water or non-sugary drink.

  • The effect of the drug resiniferatoxin on the bladder as a treatment for cases of incontinence previously unresponsive to treatment.

    This project involves administering a solution into the bladder to treat incontinence, which ahs already been used in eight countries overseas. Urge incontinence (detrusor overactivity (DO)) is treated with anticholinergic drugs which are generally palliative, not curative. Bladder instillation of vanilloids i.e. capsaicin and resiniferatoxin (RTX) for DO has shown symptomatic improvement for up to 3 months. We wish to offer this therapy for urge incontinent women who have not responded to two anticholinergic drugs. RTX will be instilled into the bladder via a urinary catheter. Women will be assessed at 1 and 3 months by routine measures. This novel project will study which types of DO respond best to the treatment

  • The effect of physiotherapy booster sessions on home exercise outcomes in people with knee osteoarthritis

    Osteoarthritis of the knee is common in older people, giving rise to pain and loss of function. Exercise is a key treatment for knee osteoarthritis with studies revealing short-term benefits of exercise for pain and function. However, exercise is generally not effective in the longer-term due to reduced adherence. Following an initial period of more intensive exercise supervision, this randomised controlled trial will investigate whether a limited number of additional physiotherapy visits will improve outcomes with home exercise over 24 weeks.

  • Assessment of relationship between segmental coronary endothelial function and plaque progression/regression

    Vascular endothelium is known to have a pivotal role in the maintenance of vascular haemostasis including effects on vasomotor and platelet function, thrombus formation and fibrinolysis, cell growth and inflammation. Altered endothelial function (endothelial dysfunction), largely evaluated by vasodilator responses to endothelial dependent stimuli (ie. shear stress, acetylcholine, salbutamol), occurs in the setting of atherosclerosis and traditional cardiovascular risk factor. Furthermore, endothelial dysfunction measured in both the peripheral and coronary circulation, is associated with adverse risk of future cardiovascular events. The exact mechanism behind how endothelial function impacts on clinical events remains uncertain. We plan to embark on a set of experiments to assess the dynamic relationship between segmental coronary endothelial function and regional plaque progression or regression over time in patients with stable coronary artery disease. We are also interested to examine this relationship with the evolution of the lipid core content of an atheromatous plaque, a known marker of plaque vulnerability. Our patients will undergo a clinical follow up every 3 month until 18 months, when another endothelial function assessment will be performed to mark the end of the study. Although this is largely a mechanistic study, we believe that the result of this study will provide some initial data to provide a "gold standard" invasive assessment of vulnerable plaque, which in turn will aid in predicting individual future coronary event with more accuracy.

  • The Hall technique in preschool children

    There are a large number of disadvantaged pre-school children who suffer tooth decay. Unfortunately, many of them require extensive treatment necessitating general anaesthesia with its risks and high costs. Preformed stainless steel crowns are the best method of restoring decayed baby molar teeth and a simplified method of placing them, without using general anaesthesia, has been found to be successful with school age children. We wish to test whether this method would be successful with pre-school children at high risk to dental caries in a community dental clinic at a success rate comparable to conventionally placed stainless steel crowns. Research Investigators include the Director of Clinical Leadership, Education and Research of Dental Health Services Victoria; senior academic staff of the Melbourne Dental School, University of Melbourne; the Manager Oral Health Program North Richmond Community Health, and a senior dentist from the North Richmond Community Dental Clinic. Participants will include North Richmond Community Health management and staff, preschool children patients (and their primary carers) of the North Richmond Community Dental Clinic. As part of the standard clinical care for patients at high risk to dental caries, the preschool children will have x-rays taken beforehand to diagnose decay and exclude from the study patients with extensive disease for which this treatment is not indicated. Multi-language brochures and dental examination with questionnaire will precede an interview to elicit verbal and written consent. Immediately after treatment, carers will be asked to fill in another questionnaire. At the 12 months review visit another x-ray will be taken, again according to standard clinical care for patients at high risk to dental caries, and a further questionnaire filled. The prime statistic will be the number of crowns deemed to be a success at six months, and 12 months (for Phase 1 of the study), using criteria established by previous research. Secondary findings will be the acceptance of this mode by patients, carers and staff. A key aspect is that, in appropriately selected cases, this treatment does not drill out any of the decay; so, does not require any injection of local analgesia, is less uncomfortable, and so is faster and likely to be better tolerated by pre-school children than conventional stainless steel crowns. A key issue is ascertaining that there is no unexpected progression of decay with poor outcomes. Research has shown that the decay of deciduous molars that is isolated under the crowns ceases and causes no further destruction to the teeth.

  • Neural adaptations to vitamin D supplementation in older adults: A pilot study

    Low vitamin D levels in the blood are a common problem in the elderly. One of the main functions of vitamin D is to help absorb calcium to keep bones strong, but low vitamin D levels have been associated with muscle weakness and an increased risk of falls. Low vitamin D levels have also been linked to a number of neurological conditions such as multiple sclerosis and Parkinson’s disease. Since the role of the nervous system is to send signals to the muscles to produce smooth and coordinated movements to maintain balance and prevent falling, it is possible that the increased risk of falling that has been associated with low vitamin D levels is related to its effects on the brain and nervous system. This study has been designed to investigate the effects of 3-months of vitamin D supplementation on muscle strength, muscle power and function as well as neural activity in the brain and nervous system in older women with mild vitamin D deficiency. Women aged 60 years and over will be randomised to receive either 2000 IU of vitamin D supplementation daily or a matched placebo control. Women will undergo muscle strength and function tests as well as non-invasive neural testing prior to study commencement and after 3 months' supplementation.

  • A study to evaluate the harmful effects of metal ions on eyesight in patients with an ASR total hip replacement.

    Total hip replacement is now a well established operation to reliably alleviate pain from osteoarthritis of the hip joint. Over the years a number of bearing surfaces have been used in order to minimise the wear within the joint itself. One such bearing surface is a metal socket articulating with a metal ball. However we know now that although this provides very low wear rates, it can result in metal ions being released into the blood stream as a result of this wear process. It is the precise effects of these metal ions within the blood stream that we are beginning to understand more about. In particular we know very little about the effect that metal ions have on the eyesight and if metal ion levels are high whether this can cause changes in visual acuity. This study aims to measure blood levels of Cobalt and Chrome in your blood stream and then potentially carry out specific tests to look at the functioning of the cells within the eyes to assess whether this is abnormal.

Tags:
  • Finding clinical trials