ANZCTR search results

Comparing the complication rate between 2 different types of ureteric stent (Magnetic stent vs stent on extraction strings) which are used during the surgical treatment of kidney stones. We believe that magnetic stent may have less complication and side effects than the stent on extraction string.

OV329 [(S)-3-amino-4-(difluoromethylene) cyclopent-1-ene-1-carboxylic acid hydrochloride salt] is a gamma aminobutyric acid (GABA) aminotransferase (GABA-AT) inhibitor that is being developed as an antiseizure medication for rare seizure disorders in adults and pediatric patients. Part A will consist of up to 5 cohorts, comprising 8 participants each. Dosing will be initiated at 1 mg/day. Subsequent cohorts will be dosed as recommended by the Data Review Committee (DRC) based on the safety, tolerability and PK of OV329 from the previous cohort. Target engagement measured by MRS will also be considered in assessing the potential dose escalation as the dose will not be increased by more than 50% relative to the previous cohort if GABA levels are 2-fold increased. Part B will consist of 3 planned cohorts comprising 8 participants each with the first 2 cohorts and the third cohort will consist of 16 participants with 12 active and 4 placebo participants. Subsequent cohorts will be dosed as recommended by the DRC based on the safety, tolerability and PK of OV329 from the previous cohort (based on review of the Day 30 data, including ophthalmological assessments). Participants will be dosed for a total of 7 days.

This study aims to explore whether an alternative label used to communicate a hypothetical low-risk prostate cancer diagnosis influences management choice and level of anxiety among partners of those with prostates. Who is it for? You may be eligible for this study if you are the partner of an adult with a prostate who does not have a history of prostate cancer. Study details Participants will be randomly assigned randomised to receive one of three hypothetical scenarios about the diagnosis of a low-risk prostate cancer received by their partner. Each group will be presented with a different diagnostic label. Within each scenario arm, participants will be further randomised to receive either limited information about their partner's diagnosis and management options, or comprehensive information. We will then survey participants about their preferred choice of management for their partner's diagnosis, their level of anxiety about that diagnosis and their level of anxiety about that management choice. It is hoped that this study will help provide additional understanding on whether labels and provision of risk information will modify any effects of labels used for a low-risk prostate cancer diagnosis.

This study aims to explore whether an alternative label used to communicate a hypothetical low-risk prostate cancer diagnosis influences management choice and level of anxiety among men in Australia. Who is it for? You may be eligible for this study if you are an adult with a prostate who does not have a history of prostate cancer. Study details Participants will be randomly assigned randomised to receive one of three hypothetical scenarios about the diagnosis of a low-risk prostate cancer received by themselves. Each group will be presented with a different diagnostic label. Within each scenario arm, participants will be further randomised to receive either limited information about their diagnosis and management options, or comprehensive information about their diagnosis. We will then survey participants about their preferred choice of management for that diagnosis, their level of anxiety about that diagnosis and their level of anxiety about that management choice. It is hoped that this study will help provide additional understanding on whether labels and provision of risk information will modify any effects of labels used for prostate cancer diagnosis.

Following the global COVID-19 pandemic, detecting viruses and infection symptomology has been important in minimising the spread of the infection but also to detect the early onset of infection in the body. This study focuses on using physiological measures, heart rate, respiration rate, sleep and temperature obtained from various non-invasive off the shelf consumer wearables (e.g., smart watches) to assist in potentially detecting the early signs of infections. Not only is this important to stop the spread of viral infections, but it could also provide insight in detecting the common cold or flu. As the spread of sicknesses can greatly affect people’s livelihood and productivity in various fields including but not exclusive to settings such as health care and the defence force, where work is 24/7 this study aims to use off the shelf consumer wearable devices (e.g., smart watch) to explore this.

This observational study takes place within Orthopaedic Spinal Clinics where staff consist of Physiotherapists and Medical Officers. The majority of patients are not likely to benefit from surgery. Instead, patients are offered reassurance regarding their spinal condition and advice to promote non-surgical strategies such as a graded activity plan. There is evidence linking reassurance to patient satisfaction and condition management however limited evidence that Physiotherapists and medical officers can equally reassure patents following an assessment in Orthopaedic spinal clinics. The primary aim of this pilot study is to evaluate the level of reassurance reported by patients via the Consultation Based Reassurance questionnaire (CRQ) following exposure to either the Physiotherapist or medical officer model of care in an Orthopaedic Spinal Clinic. Secondary outcomes of interest include pain, functional limitations and confidence managing pain symptoms. Outcomes are assessed at baseline, 1 day following clinic and 3 months following clinic.

Malnutrition is common among hip fracture patients and results in adverse outcomes. The primary aim of this study is to assess the feasibility of intervention delivery and evaluation design in preparation for a larger trial to determine whether providing high energy, high protein meals to older patients following hospitalisation for hip fracture improves patient reported measures and health related outcomes. Primary outcomes relate to feasibility of the intervention and evaluation design. Secondary outcomes include quality of life, patient-reported experience measures, nutritional, functional and health outcomes, and likelihood of cost-effectiveness. This study has potential to improve quality of life and other health outcomes post hospitalisation for hip fracture. If the intervention is shown to be feasible to deliver and evaluate, further research will assess clinical and cost effectiveness.

The purpose of this study is to assess safety of internal eucalypt sap resin consumption and also to explore if a low dose taken over a period of six months may be able to decrease vulvo-vaginal candidiasis episodes and concurrent gastrointestinal symptoms in women with recurrent vulvo-vaginal candidiasis (RVVC) and gastrointestinal symptoms of microbial imbalance. With the prevalence of RVVC and lack of safe long-term treatments for managing the symptoms of candida overgrowth (both gastrointestinal and vaginal), we are investigating this ingredient for potential in the management of RVVC alongside long-term safety.

Trials of calorie and protein delivery in critically ill patients have failed to show positive outcomes. However, these trials predominately intervene during the acute phase (first 7 days) of an Intensive Care Unit (ICU) admission only, where metabolic responses to critical illness are likely to impair nutrient utilisation. Furthermore, there is an increasing recognition that nutrition is not a short-term intervention, and extended nutrient provision is required to demonstrate benefit. Little is currently known about nutrition practices in patients that have a longer (>7 day) ICU stay. The purpose of the study is to describe nutrition practices in long-stay critically ill adult patients. 200 patients will be recruited at the Royal Adelaide Hospital. Data for all eligible patients will be extracted from the Australian New Zealand Intensive Care Society Adult Patient Database (ANZICS APD) where applicable, and additional data collected from the patient electronic medical record (EMR), bedside nursing staff, or the patient themselves. Data analysis will be conducted in SPSS Statistics software in consultation with qualified biostatistician Ms Kylie Lange from the National Health and medical Research Council (NHMRC) Centre for Research Excellence at The University of Adelaide. This prospective observational study is an integral step in defining key gaps in nutrition delivery to inform a program of research on improving patient recovery through optimal nutrition.

The aim of this research project is to investigate whether the type of interface (a face mask or a mouthpiece) used during the measurement of cough strength, called peak cough flow, changes the values obtained. While face masks are commonly used during measurements of cough strength in clinical practice, a mouthpiece can also be used. However, it is unclear whether these interfaces are interchangeable. This is important to know as differences in the measurement of cough strength due to interface type could delay access to therapies to improve cough strength. If an individual is found to have a weak cough, therapies such as a cough assist machine can be used to improve cough effectiveness. Again, both face mask and mouthpiece interfaces are used with the cough assist machine but it is unclear if interface type changes the effectiveness of the cough assist machine. Currently no studies have compared face masks and mouthpieces in the measurement of cough strength in people with respiratory muscle weakness. Similarly, there is no information about how these two interfaces studies effect how cough assist machines perform or how comfortable each interface is to use.