ANZCTR search results

The PANDA (Personalised Add-on Acupuncture Service at Northern Emergency Department for Acute Pain) project is a feasibility study aimed at integrating acupuncture into the emergency department (ED) to manage acute pain and improve patient outcomes. This interdisciplinary research investigates the effectiveness of acupuncture in reducing pain intensity, minimizing opioid use, improve the key performence index of hospital and enhancing overall patient satisfaction. The study involves non-randomized allocation of patients to either receive standard care or additional acupuncture treatment, with key outcomes measured through various clinical and patient-reported metrics. Ethical approval for the project has been granted by the St Vincent’s Hospital (Melbourne) Human Research Ethics Committee (HREC).

LOTUS is an investigator-initiated and nurse-led trial with a two-arm, open-label, randomised, multicentre design. Low dose combination therapies for treatment of hypertension and (optional factorial arm) hypercholesterolaemia will be compared to usual care in stroke survivors over 26 weeks. The primary aim of LOTUS is to assess whether an innovative model of care involving low dose antihypertensive (and optionally) lipid lowering treatment underpinned by team-based, telehealth-supported care will reduce BP over 26 weeks when compared to usual care in survivors of ischaemic stroke/transient ischaemic attack (TIA). Secondary aims include if this new model (when compared to usual care): reduces cholesterol, is acceptable to patients and clinicians, is cost-effective, improves medication adherence and patient acceptability, and is safe.

This study is investigating if Tirzepatide (trade name Mounjaro) will improve asthma symptoms in obese patients with asthma and uncontrolled symptoms. This drugs causes weight loss using glucagon like peptide (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP); to make people feel fuller for longer. Patients will be enrolled in a prospective observational cohort trial stratified for metabolic syndrome. Although improvement in asthma control is the primary outcome, secondary outcome measures include changes in serum inflammatory markers. This is because its thought that obesity causes asthma by increasing background systemic inflammation. Inflammatory markers will be measured before during and after treatment with Tirzepatide looking to see how inflammation changes with therapy. The hypothesis is that obesity associated inflammation is correlated with poor asthma control and asthma control will improve with therapy alongside a reduction in serum systemic inflammatory markers.

This is an open-label study to evaluate the safety/tolerability and pharmacokinetics of RECCE327 topical gel in the systemic circulation when applied to intact human skin. The study will also evaluate the safety and tolerability of RECCE327 topical gel when applied to intact human skin. All participants must meet all inclusion criteria and not meet any exclusion criteria. Study medication will be applied once daily for seven (7) days to normal intact skin. The location of the gel administration will be on the ventral mid-section of the forearm. Participants will be treated in an inpatient setting at the clinical site for 8 days, and return to the clinic for a follow-up visit on Day 14 (+/- 3 days).

Bone loss is a common health problem in older people, particularly women, and can significantly affect their quality of life. Progressive resistance training has been shown to be effective in preventing bone loss. However, several questions remain regarding the optimal design of such interventions. One such aspect is movement velocity. The aim of this project is to investigate whether faster movement velocities are more effective in improving bone mineral density.

This Phase 1, first-in-human, open-label, fixed-sequence, 3-period, 3-treatment study is designed to assess the skin safety, tolerability and PK of MRX-7MLL compared to the oral reference product, Namenda® (Memantine HCl oral tablet) or generic equivalent. This pilot study will also assess TDS adhesion, validate analytical methodology, assess inter- and intra-participant variability, and/or optimize PK sample collection timepoints for MRX-7MLL and oral memantine HCl tablets. The results of this study will support dose selection in future bioequivalence studies with MRX-7MLL and oral reference product or may be used to identify candidate formulation(s) for the pivotal study.

This study aims to evaluate whether a new type of brain imaging called an Amyloid PET/CT scan can improve the diagnosis of Alzheimer’s disease in patients where previous tests have been inconclusive. The hypothesis is that this scan will provide additional diagnostic information, helping doctors make a clearer diagnosis or exclude Alzheimer’s disease. Fifty patients with unclear results from an earlier scan (FDG PET/CT) will undergo the Amyloid PET/CT scan. The results will be reviewed by a team of specialists to determine if the new imaging adds value to the diagnosis.

Chronic trigeminal neuropathic pain resulting from a nerve lesion/disease and affecting the mouth/face, is a highly prevalent condition having severe effects on an individual's quality of life. Although functional brain imaging studies have established brain regions involved in chronic pain processing, the altered engagement of neuroglia astrocytes and microglia remain under-investigated. To develop personalised pain treatments, a better understanding of these non-neuronal cells which encompass and support ascending and descending pain pathways needs to be established. The aim of this proposal is to use a multimodal approach to investigate underlying neurobiology of trigeminal neuropathic pain.

It was hypothesised that combining lifestyle modification with dietary fibre supplementation will be more effective for weight loss than either strategy alone. The aim was to examine the effect of a specific lifestyle modification program (LSMA, AstonRx Program) combining time-restricted eating (TRE) and dietary fibre supplementation on body weight, body composition and biomarkers of metabolic health in healthy overweight adults. Using a randomized, double-blind, placebo-controlled trial, the study aimed to examine the effect of a specific lifestyle modification program (LSMA, AstonRx Program) combining time-restricted eating (TRE) and dietary fibre supplementation on body weight, body composition and biomarkers of metabolic health, and safety and tolerability of a new dietary fibre BioPB-01 in healthy overweight adults. The primary outcomes included – changes in body weight and composition and safety and tolerability of BioPB-01 dietary fibre. The secondary outcomes included - changes in lipid profiles, fasting blood glucose and insulin levels, gut microbiota structure and function and inflammatory markers.

The purpose of this study is to determine the effect of protein-supplementation on faecal hydrogen sulphide production in healthy adult males. We hypothesise that protein supplementation will altern the colonic microbial environment but be safe, tolerable and adhered to by healthy adult males.