ANZCTR search results

Hamstring avulsion is a common misdiagnosis for FAI and there appears to be a relationship between these two diagnoses. This relationship has never been studied. This study could contribute significantly to the global understanding of this hard to treat entity.

In this study, the research group will work with staff on a vascular surgical ward to design and introduce changes to care which are more elder-friendly, to ensure that older patients regain their usual function faster after surgery. This will include prompt input from a physician to prevent early medical complications, early input from allied health professionals such as physiotherapists and nutritionists to reduce the risks of muscle loss, and resular encouragement from all staff members to keep their body and mind as active as possible. The changes in care will be made by working closely with ward staff using an evidence-based framework for implementing complex changes in health care settings. The investigators hope to show that the new model of care improves the rate of return to independence, reduces complications and reduces length of stay in this high risk patient group, compared to the usual way of organising care. They will also assess whether these improvements justify the additional intensity (and therefore cost) of staffing which would be necessary to provide this enhanced care.

1. This is a double-blind, randomised, placebo-controlled study to evaluate the efficacy of a vitamin, mineral and herbal formulation. The aim is to investigate if the formulation reduces cold & flu symptoms including symptom duration compared to placebo. 2. All participants are provided with the cold/flu treatment pack – which includes the product (active treatment or placebo), a daily symptom diary and a pre-prepared QML pathology form for Influenza antigen testing. 3. If a participant experiences 2 or 3 more cold/flu symptoms during the 6 month study period (according to the Wisconsin Upper Respiratory Symptom Survey), they need to a) start treatment, b) have the antigen test taken at a local QML pathology collection centre, c) record their symptom severity in the diary every day until symptoms resolved. 4. Within 2 weeks from the cold/flu resolving, the participant is asked to attend a final interview, returning the diary and unused product. 5. There will be regular communication with all participants during the study. Once the number of cold/flu episodes reaches the quota (49 per group), all participants will be informed that the study has been completed. Therefore, it is expected that not all participants will experience a cold/flu episode while enrolled in the study.

This randomized controlled trial evaluated Primary Care Stepping Stones Triple P, a brief individualized parenting program, in a sample of parents of children with Autism Spectrum Disorder (ASD). It was hypothesised that parents who took part in the program would experience improvements in child behaviour problems, parenting styles, parenting confidence and parental adjustment.

This trial intends to determine whether the use of vitamin B can be used as an effective treatment for migraine. This trial will compare the migraine outcomes in those taking low or high doses of the vitamins versus people taking mock medication.

Monitoring pain in patients who are semi-conscious after an operation under general anaesthesia can be difficult. The Analgesia Nociception Index (ANI) is a monitor that claims to enable anaesthetists to monitor pain even when patients cannot communicate their pain directly. ANI is based on an analysis of the ECG signal which finally allows an estimate of the stress reaction a patient experiences during an episode of pain. The ANI score is a 0-100 score with high numbers indicating wellbeing and low numbers potentially pain. Aim of our study was to test this monitor in patients after surgery by asking the patients to rate their pain on an established pain scale and noting ANI scores at the same time. We hypothetized that ANI scores would reflect different states of pain with different ANI score results.

Polycystic ovary syndrome (PCOS) is the most common cause for women experiencing menstrual irregularity and anovulation (not releasing an egg each month), affecting up to 10% of the population. While the cause for PCOS is not fully understood, certain probable links have been identified. Almost half the individuals with PCOS have an excess of adipose (fat) tissue stored around their waist, impaired sugar metabolism (insulin resistance) and high levels of fats / cholesterol in their blood stream (dyslipidemia). The excess fat tissue is believed to activate the bodies immune system, causing inflammation which then stops ovulation and increases the ovaries production of testosterone. It is this raised testosterone that may cause acne and excess body hair- a common feature of PCOS. Being over weight and a diet high in saturated fat have both been independently linked with inflammation. Furthermore, women with PCOS are known to have signs of increased inflammation in their body compared to healthy women without PCOS. Work by our group has shown that individuals with PCOS have less than ideal diets, with high intakes of saturated fat, and a higher body mass index (BMI) than aged matched fertile counterparts. Other groups have also shown that PCOS patients have a high saturated fat intake. We have previously proposed that a high fat / low fibre diet will create disturbances in bowel bacteria, with an overgrowth of “bad” bacteria which can then pass across the gut wall into the blood stream and activate the woman’s immune system. The resulting inflammation is known to produce insulin resistance with resulting high blood levels of insulin interfering with normal egg development and ovulation, while driving up the ovaries production of testosterone, potentially causing acne and excess body hair. Probiotics are “good” or beneficial bacteria that are present in food sources such as yogurt, fermented milk drinks or can be taken as powder and capsule supplements. Probiotics are useful treatments for gastro-intestinal conditions such as constipation, antibiotic associated diarrhoea and irritable bowel syndrome (IBS). All of these clinical conditions are linked with an increase in “bad” bacteria in the gut and have been shown to cause inflammation in the gut and in the rest of the body. Probiotic “good” bacteria have the ability reduce the number of “bad” bacteria in the gut, while also helping stop these “bad” bacteria passing through the gut wall into the blood stream where they can activate inflammation. Therefore, we propose that by giving probiotic “good” bacteria supplements to women with PCOS and symptoms of excess “bad” bacteria in their gut (bloating, pain, constipation or diarrhoea) we may be able to reduce inflammation in the body, thereby reducing insulin and testosterone levels and re-starting ovulation. This is the primary research question of this study.

Currently all patients about to undergo elective surgery in common law countries are required to give their informed consent to proceed. However, the literature suggests that many participants are not well informed when they give their consent. The aim of this study is to assess baseline knoweldge of elective procedures. The secondary aim is to see if baseline knowledge can then be improved through the use of an operation-specific instructional tool

Approximately 11% of all psychiatric outpatients and 19% of psychiatric inpatients meet the criteria for Borderline Personality Disorder (BPD). People with this disorder are high utilisers of mental health services and medical services as their condition often involves problems with interpersonal relationships, impulsivity in self-damaging areas such as substance abuse and reckless driving, recurrent suicidal threats and self-harming or self-mutilating behaviours. Approximately 9% of all individuals with BPD commit suicide. DBT has become the gold standard of psychotherapeutic treatment of BPD. Results across a number of trials have consistently shown significant reductions in suicidal and self-mutilating behaviours as well as improvement in quality of life. To date, there have been very few RCTs comparing DBT to other active treatments and very few trials conducted in real world settings. This trial compares DBT with CM, a psychodynamic model, developed specifically for treatment of BPD that has some empirical support, but has not been evaluated against another active treatment. It is hypothesised that DBT will be more effective at reducing self-harm and suicidal behaviour than CM, but less effective at reducing depression.

FODMAPs are poorly absorbed sugars that putatively contribute to gastrointestinal symptoms in irritable bowel syndrome (IBS). Supporting evidence comprises confirmation of mechanisms of action, effects of acute challenge with individual FODMAPs/foods, observational studies in IBS and quiescent Crohn’s disease, randomised controlled trials of fructose and fructan rechallenges in IBS patients with controlled symptoms on a low FODMAP diet and a non-randomised comparative study. We aim to fill evidence gaps regarding effects on symptoms over the longer term with the low FODMAP diet compared to the moderate FODMAP intake on a typical Australian diet by comparing GI symptoms in unselected IBS patients consuming such diets with those in healthy and disease controls (quiescent Crohn's disease).