ANZCTR search results

The purpose of this project is to explore the efficacy of a clinician-guided education course for symptoms of anxiety and depression in tertiary students (aged 18+), administered over the internet in a randomised controlled trial. A secondary purpose is to determine the acceptability of the education protocol and materials to tertiary students with symptoms of anxiety and depression. A tertiary purpose of this project is to explore the efficacy of a self-guided version of the course, with participants from the Waitlist Control Group.

This trial will compare the sedative medicine propofol with the newer sedative dexmedetomidine. The comparison will take place in a group of patients having replacement of their hips or knees with mechanical joints. The study will look at patients undergoing this surgery under a spinal block, where the body is made numb from the waist downwards. Typically these patients have some sort of sedation to make them more comfortable and less aware of noise or movement in the operating theatre. The most commonly used infusion, propofol has some side effects including reduced breathing efforts, which sometimes requires the anaesthetist to intervene and support the airway or even convert the sedation to a full anaesthetic. A newer sedative medicine, dexmedetomidine appears to have fewer of these effects. It may be that it is a better option for this sort of sedation. Some mild side effects such as changes in pulse rate have been associated with dexmedetomidine but these do not appear to be severe enough to prevent its usefulness in this setting. Patients will be randomized to receive either propofol or dexmedetomidine. They will receive their normal regional (eg “spinal” ) anaesthetic. The researchers will be measuring: Patient satisfaction with the sedation experience (within one week of surgery); Need for airway support; and haemodynamic values intraoperatively.

Queensland Health Medical Imaging survey data has highlighted only 39% of all radiologist (medical) diagnostic reports are available within 24 hours. The absence of a radiologist report or radiographer comments within clinically relevant timeframes represent ongoing potential risks to patients through missed diagnosis. There is increasing evidence that a radiographer (allied health) commenting system that highlights and describes acute abnormalities, improves service delivery, aids in improving a quality diagnosis, and above all else improves patient care in trauma settings (such as Emergency Departments). Radiographer commenting is not intended to replace the role of radiologist reports, but assist multidisciplinary clinical teams and radiologist when viewing and interpreting x-rays. Importantly, radiographer performance in this regard can be improved as a result of targeted education in image interpretation. A radiographer commenting system is not currently used in Queensland Health, despite evidence of its benefit and adoption elsewhere (such as the UK, NHS). Targeted education for image interpretation is a priority for radiographers within Queensland Health. To date there has been no study comparing education delivery methods of an image interpretation program for radiographers. The purpose of this project is to assess the comparative merits of two education delivery methods as a tool for improving the ability of radiographers to detect and comment on, abnormalities visualised on trauma radiographs. This critical evidence will inform the rollout of targeted training for radiographers within Queensland Health and is likely to influence clinical education in national and international healthcare settings.

Subjects were required to take two capsules each time, three times daily (with four hours interval) for a period of eight weeks. Each capsule contained 500 mg of a mixture of granules of either herbal medicine (Koda Internationals Pty Ltd, Lane Cove, N.S W. Australia) or placebo ingredient (rice starch from Sigma Pharmaceuticals Pty Ltd (Melbourne, Victoria, Australia). The capsules were prepared by a TGA approved Good Manufacturing Practice (GMP) certified manufacturer (GMP Pharmaceuticals Pty Ltd Girraween, N.S.W. Australia). The two types of capsules were identical in weight and appearance.

1. The overall aim is to provide nutritional intervention as part of the multi-disciplinary management of A-T patients attending the national clinic. 2. To evaluate the effectiveness of standard nutritional advice and standardised supplements for improving intakes and outcomes in A-T. 3. To implement a randomised controlled age-matched cross-over trial design to evaluate the efficacy of a conjunctive anti-oxidant therapy using whole food ingredients to limit or reduce oxidative stress and improve outcomes in A-T.

The insertion of a needle through the skin, as commonly used to deliver a vaccine or sample blood, into a superficial vein is associated with a degree of pain and discomfort. In addition, many individuals, especially children and their carers, experience strong anxiety associated with, or in expectation of, that pain. This project aims to test the efficacy a simple, fast acting topically applied patented device containing a commonly used local anaesthetic agent, in reducing the pain and discomfort associated with needle insertion. Our hypothesis is that the application of the pad with an active agent for topical anesthesia for 10 minutes is more effective in reducing or eliminating pain and discomfort from needle stick injections compared to application of a placebo pad.

The purpose of this study is to trial a specific exercise program to support the musician's playing actions and movement patterns, and examine any effects on pain. Information collected relating to changes in frequency and intensity of Performance-Related Musculoskeletal Disorders will be used to evaluate the effects of the exercise or Alexander technique programs and these results will be compared to the control group. Data obtained on playing postures, playing techniques and perceived exertion will also be evaluated for differences between the pre-intervention and post-intervention conditions.

This study has been designed to investigate how the load of Whey Protein Hydolysate effects gut motility, gut hormones, and appetite sensations in obese individuals. Further, how response to a specific load of Whey Protein Hydolysate differs between obese and age-matched lean individuals will be investigated. There is evidence that protein more potently suppresses appetite and energy intake than carbohydrate and fat, however, the mechanisms behind this are not clear, and many studies show variable results due to differences in methodology. Our team has developed an intraduodenal infusion protocol appropriate to characterise the effects of varying protein loads in lean individuals on antropyloroduodenal motility, hormone release, and energy intake. Evidence suggests that normal hormone release and motility responses are perturbed in obese individuals. Thus, this study aims to characterise the effects of protein loads on gut motility, gut hormones, appetite sensations, and subsequent energy intake in obese individuals. We hypothesise that protein will modulate these parameters in a load-dependent manner, however, obese subjects will be less sensitive to loads of protein infused into the duodenum, compared to a healthy lean population. The results of this study may aid food and pharmaceutical industries in identifying appropriate responses to aid body weight management.

This research project is aiming to determine the effects of glucose and caffeine on cognitive function, stress and mood. Both caffeine and glucose are said to play a role in improving attentional resources with attending to activities with a high cognitive demand. This project will assess the effectiveness of various levels of caffeine and glucose combination drinks on performance of a multitasking battery and mood measures. Further measures for a subset of participant will include an MRI scan where performance on attentional tasks will be evaluated. Participants will be required to attend four testing sessions (and one practice session). Each session will see participants taking one of four drink interventions; (1) Caffeine drink (40mg caffeine) (2) Caffeine and Glucose Drink (25mg Glucose, 40mg caffeine) (3) Caffeine and Glucose Drink (60mg Glucose, 40mg caffeine) (4) Placebo

This research study aims to test how effective the BioNessL300 is on fatigue induced gait variability in people with MS. In this study participants will wear a commercially available peroneal nerve stimulator (NessL300) for 8 weeks. The first 3 weeks will consist of training and acclimatisation to the device, starting at 15 minutes per day, building up to 8 hours of use per day. Participants will then continue to use the device as an orthosis for the next 5 weeks.