ANZCTR search results

Aims This study aims to test the effect of informing and reminding patients, GPs and practice nurses opportunistically about care aimed at preventing, detecting and treating osteoporosis. Research design Cluster randomised controlled trial Methods Existing opportunistic reminder software used in general practices will be enhanced to provide reminders about osteoporosis-related care. Ten general practices will be randomised to a ‘usual care’ control group or to the intervention group, in which patients attending for consultations for whom osteoporosis-related care is due will receive an automatically-printed sheet of information and advice when they arrive for their consultation. The sheet will advise them to ask their GP or nurse about the care that is due. GPs and practice nurses will receive on-screen reminders during those consultations about the osteoporosis-related care that is due to be performed for the patient. Likely outcomes and benefits Performance of osteoporosis-related care will be significantly improved by the intervention. Widespread implementation of this strategy is expected to reduce the prevalence of osteoporosis and the loss of healthy life years resulting from preventable fractures. This will improve population health and reduce costs of health care.

The study will evaluate the effects of a D-xylose preload, with or without sitagliptin, on incretin hormone secretion, gastric emptying, and postprandial glycaemia in patients with type 2 diabetes.

The purpose of this trial is to test 3 dose levels of an investigational drug in people with the medically diagnosed eye condition 'Age-related Macular Degeneration' (AMD). You will be allocated to a cohort in a sequential/rolling manner, depending on the time that you are screened for the trial. The aim is to find the optimum dose that is not only safe but may also have a beneficial effect on the condition. During the course of the trial, you will certain assessments conducted such as having blood samples taken, ophthalmologic assessments. physical exams and having certain photographs/images take of the eye. These will enable the objectives of the trial to be assessed.

Lateral hip pain is very common in the community and particularly in active women. Some studies state that 1 in 4 women over 55 have this problem. The pain at the side of the hip, or lateral gluteal region, can be very debilitating and often affects sleep, walking, going up stairs, prolonged sitting and getting up after sitting. The management of lateral hip pain is difficult and the pain can persist for months or even years. Previously this was incorrectly diagnosed as bursitis, but recent medical imaging research using ultrasound and MRI has shown the problem is usually due to tendinopathy or a tear in the tendons of the muscles at the side of the hip called the gluteus medius and gluteus minimus. The bursitis (a collection of fluid) appears to be secondary to the tendon injury. Common approaches to management include a corticosteroid injection or a physiotherapy program, yet there is a lack of quality research regarding which is more effective, or if in fact these treatments are any better than adopting a wait and see approach to allow the condition to resolve spontaneously. The purpose of this study is to compare the effects of three possible approaches to treating long standing lateral hip pain: (a) a single cortisone injection, (b) an eight-week physiotherapy exercise program and (c) adopting a wait and see approach. The results will contribute to the development of improved and more effective exercise treatment programs to manage this condition.

A major contributing factor to the vulnerability of patients with T1DM to hypoglycaemia is a defective counter-regulatory hormone response. It has been proposed that the loss of the glucagon response to hypoglycaemia is linked to the loss of the c-peptide. The aim of the study was to investigate whether tight glycaemic control from diagnosis can preserve the glucagon response to hypoglycaemia. Newly diagnosed adolescents with T1DM were randomly assigned to pump therapy with intensive management or MDI. Hypoglycaemic hyperinsulinaemic clamp studies were performed at 6 weeks, 9 months and 18 months after diagnosis. At each study session, glucagon response following 40 mins of hypoglycaemia and after arginine stimulation was assessed, as well as c-peptide response to a meal challenge. HbA1c was measured 3 monthly. To analyse surrounding factors questionnaires on quality of life and diet were completed as well.

The purpose of this study is to determine whether a variety of gender specific invitational strategies result in higher levels of bowel cancer screening participation compared to standard invitations. Who is it for? You may be invited to join this study if you are a male aged between 50-74 years who resides in a major urban area of NSW, SA, VIC, QLD or WA. You may not be eligible to participate in the screening test if you have bowel cancer or other colon diseases. Trial details Participants in this study will be randomly (by chance) allocated to one of four groups. Those in group one will receive the standard invitation to participate in faecal occult blood testing (FOBT) screening for bowel cancer. This includes a standard notification letter and a screening invitation package sent 2 weeks later which includes the FOBT with instructions. Participants in group two will receive a gender specific advance notification letter plus standard invitation, whilst men in group three will receive a standard advance notification letter plus gender specific invitation. Participants in the fourth group will receive the gender specific advance notification plus gender specific invitation. All men will be given 12 weeks to return the screening test. It is anticipated that invitational strategies that are targeted to male attitudes and beliefs regarding bowel cancer screening will be more effective in encouraging participation in screening than the standard invitation.

To determine if preconditioning will have a beneficial effect on the metabolic derangements associated with obesity.

This study will follow a randomized, double blind, placebo-controlled, cross over design. 20 participants will complete the study, of which 15 will take part in the SST/CDB part and 5 participants will take part in the fMRI component with the RVIP and inspection time tasks. For the 15 participant group, they will attend 3 testing days and will first do baseline testing of the CDB, followed by treatment administration and post dose testing of all tasks at 30min post dose (post dose testing will consist of CDB and SST. For the fMRI group, participants will consume their allocated treatment and undergo the cognitive tasks in the fMRI scanner 30mins post dose.

The purpose of this study is to determine whether the DePuy AVN Cage is a safe and effective treatment for avascular necrosis of the hip in patients for whom the disease has not yet progressed beyond a certain stage. Each surgery will be considered a success if 2 years after surgery the disease has not progressed to the next stage and if the patient has no need for further surgery on that hip.

This randomised controlled trial will compare the effect of an 8-week mentored physical activity program called Walkabout compared with a social program for young adults with Down syndrome aged 18-35 years. Specifically, it will examine if Walkabout increases their level of physical activity.