ANZCTR search results

Objectives: This randomised controlled trial (n = 122) compared the effectiveness of a nurse practitioner (NP) pain management intervention commencing with immediate release oxycodone the day after caesarean section compared to standard care with a prescription of controlled release oxycodone. Methods: A pain management plan based on immediate release oxycodone was developed for each woman in the intervention group. The NP addressed psychosocial aspects of pain in order to (1) reduce pain intensity, (2) decrease pain interference on maternal function and recovery, and (3) increase maternal control over pain management. The control group received standard care including controlled-release oxycodone prescribed twice daily for two days.

Single fasting blood samples will be collected from each study participant for analysis of pro-inflammatory mediators and oxidative stress. At the time of blood sample collection, isolated neutrophils will be for measurement of superoxide production and elastase activity. Results of pro-inflammatory mediators and oxidative stress obtained from liver tranaplantation recepients will be statistically compared to those obtained from healthy controls using analysis of variance (ANOVA).

Polycystic ovary syndrome (PCOS) affects ~21% of Australian reproductive aged women, has reproductive, psychological and metabolic features (increased diabetes) and is exacerbated by obesity. This randomized control trial will evaluate the benefits of behavioural modification training plus 1) lifestyle advice 2) low intensity exercise and 3)high intensity exercise on metabolic and reproductive health, and sustained exercise engagement. We hypothesize that high intensity intermittent exercise may be more effective in managing the poor metabolic, reproductive and psychological health in women with PCOS, as well as offering a more engaging and enjoyable exercise modality for improved lifestyle modifications as recommended by the national guidelines for management of PCOS.

The main purpose of this study is to examine the feasibility, of a promising intervention (exercise) that never became a standard treatment but with widespread acceptance with the evidence being mainly anecdotal. This study has been designed to optimise the training, content, and delivery of exercises to participants with menstrual pain. The specific objectives for this study are to: 1.To assess recruitment processes and study uptake to inform the feasibility of running a full study 2. To evaluate the retention rate of participants 3. To evaluate the study protocol 4. To determine the feasibility of the proposed outcome measures 5. To estimate the effect size of the intervention The experimental hypothesis is that a treatment program consisting of aerobic training, strengthening and stretching exercises would be effective in reducing the menstrual pain and severity among women with Primary dysmenorrhea

This study examines the effect of weight cycling on iron status, inflammation and immune function. The objective is to measure iron levels, inflammation and the immune systems of young women and then investigate how weight cycling can affect these factors. This research study is part of larger trial that is comparing the effectiveness of a red meat based, low fat diet and a white meat based, low fat diet on weight loss, immune function, blood fats, glucose, insulin and iron levels.

Almost a decade ago, the SAFE study provided information on the effect of saline and albumin resuscitation fluids in adult patients in intensive care. Despite further studies, there remains a paucity of data on the most appropriate resuscitation fluid in infants and children in intensive care. The SAFE Extrapolation to Paediatric Intensive Care (SAFE-EPIC) study is an international point prevalence study of fluid resuscitation practice in paediatric patients in intensive care. The SAFE-EPIC study aims to describe the type of fluid used and the patient and intensive care unit factors associated with the use of this fluid in paediatric patients (0 – 16 years) in registered intensive care sites in countries throughout the world on two study dates (one in December 2012, and one in July 2013).

Indigenous Australians comprise a major proportion of the Central Australia population and there are a number of issues relating to those requiring critical care for sepsis, including higher rates of bacteraemia and poorer socio-economic status compared with non-indigenous populations in Australia. Despite high sunlight exposure in this region, it is thought that a combination of factors is likely to contribute to lower vitamin D levels among this population. The study will aim to establish baseline vitamin D levels in critically ill patients with sepsis in a Central Australian population. Our hypothesis is that there will be a significant degree of vitamin D deficiency in the critically ill, particularly among the septic cohort, and that it may be so prevalent as to justify routine supplementation in all critically ill patients without prior screening, further down the track

Background: Physical activity is reduced during the post-partum period. Facebook is frequently used by Australian mothers, and offers flexibility, high levels of engagement and the ability to disseminate information and advice via social contacts. The Mums Step it Up Program is a newly developed 50 day team-based physical activity intervention delivered via a Facebook app. The program involves post-partum women working in teams of 4-8 friends aiming to achieve 10,000 steps per day measured by a pedometer. Women are encouraged to use the app to log their daily steps and undertake social and supportive interactions with their friends and other participants. This study aims to determine the effectiveness of the Mums Step it Up Program. Method/Design: A sample of 126 women up to 12 months post-partum will be recruited through community-based health and family services. Participants will be randomly allocated into one of three groups: control, pedometer only and the Mums Step it Up Program. Assessments will be completed at baseline, 6 weeks and 6 months. The primary outcome (objective physical activity) and the secondary outcomes (sleep quality and quantity, depressive symptoms, weight and quality of life) will be used to determine the effectiveness of the Mums Step it Up Program compared with the control and pedometer only groups. Analyses will be undertaken on an intention to treat basis using random effects mixed modeling. The effect of theorized mediators (physical activity attitudes, subjective norms and perceived behavioral control) will also be examined. Discussion: This study will provide information about the potential of a Facebook app for the delivery of health behavior interventions. If this intervention proves to be effective it will be released on a mass scale and promoted to the general public.

Although intramuscular injections of androgen's are known to be effective, they result in varying degrees of pain at the injection site that may last for a day or two. These injections need to be given into a precise location of the buttocks and require staff with expert training. Unlike many other injections these cannot be self-injected due to the difficulty of safely injecting into the buttocks. A SC injection, if effective, may be given by yourself in your own home, which would be more convenient to avoid extra medical visits as well as saving GP and hospital resources. Many men who require androgen replacement therapy may have bleeding disorders or are on medications that may intentionally slow the ability of their blood to clot. These men have a theoretical risk of bleeding and a very large bruise deep in an important muscle may later become infected and cause significant disability. As a result men using these anti-clotting drugs are usually prescribed other forms of androgen replacement therapy that are not always optimal. A SC injection, if effective, may be used in these men. Nandrolone decanoate (ND) Subcutaneous (SC) will be trialed in healthy volunteers,with a historical, intramuscular (IM) control data set. This is the first stage of a 2 stage research study

It is well established that parents of primary school aged children substantially influence the food and physical activity home environment through behaviours, attitudes, feeding styles and role modelling. However, the contribution of fathers’ influence on children’s physical activity and eating behaviour is often overlooked.The Healthy Dads Healthy Kids (HDHK) project is based on research that shows the eating habits and exercise routine of fathers and father figures influence the ways in which the whole family approaches their health. The program was developed and successfully trialled at the University of Newcastle, with trial results showing that the major aims of HDHK were achieved. These were (i) to help overweight/obese fathers achieve a healthy weight, and (ii) to improve the activity and eating behaviours of their children (using fathers as the key agents of behaviour change). Phase 1 of the HDHK community effectiveness trial (http://www.anzctr.org.au/trial_view.aspx?ID=335368 ) was to evaluate the impact of the program in a community setting with trained local facilitators, employing a RCT design. The intention of this current project (Phase 2) is to research the effectivenss of the HDHK program on a larger scale community roll-out using a non-randomized, prospective design.