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DAILIES TOTAL1 RegisteredTradeMark by CIBA VISION is one of the new silicone hydrogel daily disposable lenses recently released into the contact lens market. This study intends to provide more information on the clinical performance of DAILIES TOTAL1 RegisteredTradeMark in terms of ocular health, vision and subjective comfort. It will allow for comparisons to previous and future contact lens related studies in the hope that it can contribute to further understanding on what causes cotnact lens related discomfort and dryness. The hypothesis of this study is that the ocular responses and subjective comfort ratings will be dissimilar in participants wearing DAILIES TOTAL1 RegisteredTradeMark and other lens types.

Progressive Supranuclear Palsy (PSP) is an idiopathic, rapidly progressive neurodegenerative disease for which there is currently no diagnostic test or any disease modifying treatment. It is caused by an accumulation of mictotubule associated tau protein in the basal ganglia, midbrain and cortical regions. There is selective loss of inhibitory interneurones and corticocortical projections leading to frontal atrophy which may correlate with the motor and cognitive disabilities. Transcranial Magnetic Stimulation is capable of inducing action potentials in cortical neurones, and provides the capacity to measure cortical neuronal excitabilityand interneuronal function. Preliminary data shows this may be a method for measuring neuronal function in PSP, which may enable its use as a biomarker. The intention of this study is to determine if these measure ments are able to distinguish PSP from other parkinsonian syndromes with similar clinical features, and if these measurements correlate with advancing clinical features over time.

The aim of this study is to find out if people following a distal radal fracture recover better if they receive a progressive exercise program. Our hypothesis is that a progressive exercise program imiplemented during the rehabilitation phase following a distal radius fracture in addition to advice will achieve better recovery of upper limb activity and functional activities than advice alone.

Clariti TradeMark 1day by Sauflon Pharmaceuticals is one of the new silicone hydrogel daily disposable lenses recently released into the contact lens market. This study intends to provide more information on the clinical performance of Clariti TradeMark 1 Day in terms of ocular health, vision and subjective comfort. It will allow for comparisons to previous and future contact lens related studies in the hope that it can contribute to further understanding on what causes contact lens related discomfort and dryness. The hypothesis of this study is that the ocular responses and subjective comfort ratings will be dissimilar in participants wearing Clariti TradeMark 1 Day and other lens types.

A major focus on weight gain prevention is urgently needed in all population groups including adults who are still within the healthy weight range as well as in those already overweight. Women are an important target group with greater prevalence of obesity, in particular abdominal obesity. Weight gain prevention has the potential to underpin and reduce the need for, intensive and costly obesity treatment programs. information alone. Women in rural communities are living with greater disadvantage, limited access to health services, and according to the longitudinal data from Women’s Health Australia, are gaining weight faster than urban dwelling women. The positive effect of the HeLP-her intervention requires confirmation in larger studies, over longer time periods, in diverse populations and settings. The proposed trial presents an opportunity to evaluate the effectiveness of HeLP-her in young, rural women with benefits to physical, metabolic and reproductive health. If, as appears likely, we can prevent weight gain with a simple intervention which proves to be cost effective and can be delivered easily to most women in Australia, we can make a significant contribution toward preventing the predicted upward shift in population weight and the consequences of obesity related illness. The Healthy Lifestyle Program (HeLP-her) is voluntary and participants were able to withdraw at any stage within the program. Written consent was provided by all participants and data collected was stored in a de-identified manner to ensure participant confidentiality.

Our group has recently found that women with primary Sjogren’s syndrome (an autoimmune disease causing dry eyes and mouth) are considerably more likely to suffer obstructive sleep apnoea (OSA) compared to women without Sjogren’s syndrome. OSA is a common condition in which the upper airway repeatedly closes during sleep and can lead to severe daytime sleepiness, one of the common problems reported by Sjogren’s sufferers. A likely key cause of OSA in Sjogren’s syndrome is reduced and stickier airway secretions that may predispose to airway obstruction and disturbed sleep at night. Recent research in OSA patients without Sjogren’s syndrome has shown that lubricating the upper airway with a substance called surfactant improves OSA. Surfactants are naturally produced in the lung and work by decreasing the “stickiness” (surface tension) of fluids. Therefore, at least in OSA patients without Sjogren’s syndrome, surfactants applied to the upper airway appear to help the airway to stay open and reopen more easily if it becomes closed. Women with Sjogren’s syndrome are likely to similarly benefit from this form of treatment. The aim of this study is to determine whether the topical application of surfactant in women with primary Sjogren’s Syndrome who have obstructive sleep apnoea as well, will reduce the severity of their OSA and salivary stickiness and will improve their symptoms of overnight dryness and general morning well-being or not.

This project aims to see if a 4 week rehabilitation program will improve the health of older people living in an aged care facility who have recently had a hip fracture.

This study will evaluate a new model of care which aims to improve the introduction process for new patients coming into the palliaitve care service. Palliative care is based on a philosphy that acknowledges the physical, social, psychological, spiritual and cultural elements which make up the total patient. By introducing a comprehensive multidisciplinary assessment process it is hoped that patients will feel that they have been understood and that their presenting illness is understood within a context of their own value and belief base. As a result of this multidisciplinary assessment clinic the care plan will reflect the domains of care that contribute to 'good palliative care'and that patients and their families will have a solid understanding of what they can expect from a referral to a specialist palliative care service.

Malnutrition is a significant and highly prevalent problem in those undergoing peritoneal dialysis (PD), and has been associated with increased morbidity and mortality. PD patients often experience gastrointestinal symptoms and together with a fluid restricted diet can limit the tolerance to nutritional supplements. The goal of this study is to evaluate the efficacy of provision of a nutritional supplement, given as a liquid (drink) or a food (snack bar) for improving the health outcomes of PD patients who are malnourished.

The Brien Holden Vision Institute (previously known as the Institute for Eye Research) conducted a clinical trial to test commercially-available multifocal contact lenses for their potential to control the progression of myopia in children(IERP2007-009, ACTRN12611001148965). The trial was completed in 2008. Approximately half of the 40 children who participated in trial IERP2007-009 were enrolled in a subsequent myopia control trial at the Brien Holden Vision Institute (IER2008-001, ACTRN12611001141932) in which all participants wore the test product of trial IERP2007-009. This research is based on the hypothesis that the peripheral retina plays a role in controlling the refractive development of the eye as shown in animal experiments (Smith et al. 2007).