ANZCTR search results

In this study, we hope to examine tDCS effects on global arousal and attention levels. Combining evidence gathered from animal models, psychological models, pharmaceutical research, and neurostimulatory research - we hope not only to better elucidate the overall arousal/attention correlation, but also to determine if noninvasive brain-modulation can produce effects comparable to certain drug classes.

A 2011 multicentre randomized control trial, undertaken by Aujesky et al, has supported recent changes to European and American Guidelines, and provides convincing evidence that the outpatient management of low-risk pulmonary embolism (PE), is non-inferior to standard inpatient management. EDPED is a comparative cost analysis (randomised control feasability study) between outpatient and delayed outpatient management of low risk PE diagnosed in the emergency department (ED). This study aims primarily to quantify the savings to the Health Department (cost per patient and cost per institution), and qualify patient satisfaction as a result of early discharge from ED. We hope to identify potential areas where health resources may be better directed in the management of low-risk PE. Secondary outcomes will address safety issues of managing PE in the Outpatient Setting (HITH). Patients who are discharged directly from ED (the intervention group) will be closely monitored for complications of their PE / venous thromboembolism or anticoagulation by HITH until their INRs have been stabilized. They will all receive a Respiratory Outpatient appointment 1 week after discharge from ED. Patients who are admitted to Respiratory Medicine from ED will be discharged to HITH in the conventional way (the control group). EDPED will examine primary and secondary outcomes within 90 days of patient arrival to ED.

The project seeks to measure oxygen consumption by precision addition of oxygen to the mixed expired gas until the mixed expired pO2 equals the inspired pO2

Bacterial Vaginosis (BV) is very common clinical condition with prevalence rates between 10 and 30 % of women in the reproductive age group. While in some cases BV is asymptomatic, in many women BV produces annoying symptoms (vaginal discharge, offensive smell). BV may also interfer with successful implantation of an embryo during IVF treatment, as these bacteria may be introduced from the vagina into the uterus at the time of the embryo transfer, causing inflammation of the uterine lining (endometrium). BV has been linked with a reduction in implantation rates in IVF and an increase risk of miscarriage. Therefore effective long term treatment/ prevention of BV in an IVF setting is important. The aim of this study is to determine if the oral administration of a probiotic can result in vaginal colonization and a subsequent reduction in reoccurance of BV infection after antibiotic (tinidazole) treatment.

To see if the broader lateral shoulder of the CPT stem affords more rotational stability than that recorded for other polished tapered stems.

The primary aim of this study will be to conduct a small trial to test the effectiveness of a GAD-specific program with a group of children suffering from GAD, by comparing a treatment group with a wait-list control group. It is hypothesised that children in the active treatment condition, will demonstrate significantly greater reductions from pre-treatment to post-treatment in primary GAD diagnostic status, self and parent-reported anxiety, overall global functioning.

Endoscopic retrograde cholangiopancreatoscopy (ERCP) is a procedure that can assist in the treatment and diagnosis of liver disease as well as gallstone disease. Like all medical procedures, ERCP is associated with complications specifically infalmmation of the pancreas (pancreatitis). Pancreatitis is often associated with more difficult procedures that take longer than normal to complete. In these situations special techniques may be used to successfully complete the procedure, such as directly cutting into the drainage tube (bile duct)from the liver - this is called a needle knife cutting technique. This study looks at whether the use of this needle knife cutting technique may prevent or reduce the risk of pancreatitis complications if performed at an earlier stage.

The purose of this study is to understand how well Oxycodone in combination with tocopheryl phosphate mix (TPM), is absorbed through the skin and into the bloodstream, with the use of a patch.

Fatty meals can cause damage to the body, known as oxidative damage. They do this by decreasing protective antioxidant levels/activity, through using them up. When this oxidative damage occurs, an inflammatory response can occur, with the release of inflammatory signalling molecules (cytokines). Over time oxidative damage and inflammation can lead to detrimental health effects such as cardiovascular disease, diabetes and cancer. This current study aims to determine if consumption of an antioxidant containing cocoa drink at the same time as a high fat meal can improve the body's own antioxidant defenses, as well as reduce oxidative damage markers and inflammatory cytokine levels. We anticipated that cocoa consumed at the same time should help to stop the unhealthy effects (eg. lower antioxidants, increased oxidative stress, and higher inflammatory response) caused by a high fat meal.

This project aims to discover the contribution of certain mechanisms of action within sleep restriction therapy for insomnia disorder. Insomnia disorder can be treated by the use of Cognitive Behavioural Therapy for insomnia (CBT-I). Within this Sleep Restriction Therapy is considered a key component. Yet, a lack of evidence exists to determine the mechanisms of action within this treatment option. Therefore, this study will look to examine changes in the contribution of certain sleep-wake mechanisms. Namely, the circadian drives for sleep and the homeostatic sleep drive or ‘pressure’ for sleep. In addition, we will also look to measure subjective changes in the perception of sleep through questionnaire response.