ANZCTR search results

These search results are from the Australian New Zealand Clinical Trials Registry (ANZCTR).

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31382 results sorted by trial registration date.
  • Total and free serum Ropivacaine Concentrations for patients receiving Continuous Transversus Abdominis plane block for Postoperative analgesia after abdominal surgery: Pilot Study

    This is a pilot study looking into safety of giving bolus of ropivacaine followed by continous infusion for 48 hrs in Transversus Abdominis Plane Block. Safety of this regime will be established by serial blood samples to analyse toal & free ropivacaine concentration , Serail ECG 's looking into QTc interval & patient will be observed for sign & symptoms of Local anaesthetic toxicity

  • Preventing falls in older people in residential care settings: improving balance through Tai Chi and Yoga - a randomised controlled study.

    The main aims of the study are to: 1. Determine the feasibility of conducting a 14- week Tai Chi or Yoga program in a residential care setting. 2. Observe and record the modified Tai Chi and Yoga approaches used for older people with different levels of balance ability 3. Determine the feasibility of detecting changes in balance, pain experience, quality of life and incidence of falls in older residents who follow the Yoga/ Tai Chi programs compared to those who receive usual care.

  • Validating fatigue crash risk and ocular measures of alertness in drivers

    This study will evaluate which ocular measures of alertness are capable of detecting driving impairment during a two hour track driving session. Drivers will be assessed twice: once when rested and once following 30 hours of continuous wakefulness. Additional assessments of reaction time and sustained attention will be undertaken. These findings will help to determine the validity of ocular measures as a tool for fatigue detection, with the aim of reducing sleep-related motor vehicle accidents. In addition, ten professional drivers will be observed carrying out their normal driving duties for 2000km. Assessments will include lane deviation and ocular measures using Optalert. Daily measures of PVT performance and KSS scores will be taken.

  • Phase 3 Study to Compare the Efficacy and Safety of Eribulin With Treatment of Physician's Choice in Subjects With Advanced Non-Small Cell Lung Cancer

    This is a randomized, open-label, multicenter, Phase 3 study, comparing the efficacy and safety of eribulin with TPC in subjects with advanced NSCLC and disease progression following at least two prior regimens for advanced disease, which should have included a platinum-based regimen.

  • Determining risk factors for surgical wound dehiscence (splitting) after surgery and the development of a surgical wound dehiscence risk tool (SWDRT).

    The study will be investigating the suspected causes of surgical wound dehiscence and will develop a diagnostic tool to be used in a clinical setting.

  • DNA damage and Nutritional Profile of ApoE4 carriers, the Major Genetic Risk Factor for Alzheimer’s Disease

    Alzheimer’s disease (AD) is the most common form of dementia, currently affecting at least 35 million people worldwide and expected to double every 20 years. The risk of acquiring Alzheimer’s doubles every five years after the age of 65 and may be affected by common alterations in the fat transporter gene (APOE). The brain contains large proportions of fats such as cholesterol and omega-3 fatty acids. APOE plays a crucial role in maintaining healthy fat distribution such as cholesterol and omega-3 fatty acids, as well as brain cell repair and scavenging of toxins. Common alterations in the APOE gene, may directly or indirectly increase DNA damage and accelerate brain aging and degeneration. This disease is currently considered incurable and greatly highlights the need for preventative measures and therapeutic interventions, such as nutritional supplementation, that may improve DNA stability and mental health.

  • Can exercise reduce treatment toxicity during the initial phase of testosterone suppression in prostate cancer patients?

    This study aims to determine if immediate exercise therapy can improve health by reducing initial adverse effects during the initial phase of AST and if this provides superior benefits to delayed exercise therapy. Who is it for? You may be eligible to join this study if you are a man with prostate cancer who is about to initiate AST. Trial details. Participants in this trial will be randomly (by chance) allocated to one of two groups. One group will immediately undergo supervised exercise training 3 times per week for 6 months. This involves aerobic (walking/jogging, cycling, rowing), resistance (lifting weights), and impact (hopping, jumping) exercises and then monitored (without training) for a further 6months. The other group will be assigned to usual care for the first 6 months. After this time participants in this group will commence the exercise program for the next 6 months. Participants will have measurements of bone mineral density, body composition, blood markers, blood pressure, arterial stiffness taken at 4 occasions (baseline, 3-, 6-, and 12-months). Participants will also complete tests of their muscle strength, balance and physical function as well as complete a series of questionnaires at these time points.

  • A randomised controlled trial to improve depression in family carers through a physical activity intervention

    Most older people with disabilities live in the community with support from informal carers. Whilst carers are generally willing to take on the caring role, it often has an adverse impact on their physical and emotional health, particularly depression. There is evidence that the lower the care recipient’s function, the more their carer experiences these problems. Whilst the effectiveness of exercise interventions for older individuals has been demonstrated, to our knowledge this is the first RCT that targets both the care recipient and the carer. This study will address the question of whether an individualised physical activity program for care recipient/carer dyads (that they can do together) can improve both the physical and psychological wellbeing of the care recipient and their carer. It will also examine whether the intervention is cost effective.

  • Prostaglandin gel versus oxytocin for induction of labour in term prelabour rupture of membranes

    Term PROM is a common problem. Women have traditionally been offered oxytocin infusion. This requires intravenous fluids, continuous FHR monitoring and the woman is restricted to bed. PG gel has been shown in a large RCT to be safe and effective but has not become widely used in the public sector. This study will address safety and efficacy as well as womens satisfaction of the two methods of induction.

  • A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial to Assess the Efficacy and Safety of 12 Weeks of Satiereal(R) Supplementation on Food Cravings and Preferences, Body Composition, Satiety and Appetite Regulatory Hormones, and Clinical Safety Markers in Overweight/Obese Individuals

    The primary purpose of the study is to assess the efficacy and safety of 12 Weeks supplementation of a novel extract of saffron stigma, Satiereal (Registered Trademark) on food cravings and preferences, body composition, satiety and appetite regulatory hormones, and clinical safety markers in overweight/obese individuals. We hypothesize that oral supplementation with Satiereal may reduce snacking and enhance satiety through its suggested mood-improving effect, and thus contribute to weight loss and/or maintenance.

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