ANZCTR search results

We sought to introduce and evaluate the practice of ‘nurse-initiated analgesia’ in the emergency department of a busy tertiary hospital in Western Australia, whereby the ED triage nurse (or other specifically trained ED nurse) administered analgesic medications according to a pre-defined protocol, without the patient being first assessed by a medical officer.

The Vitamin D study in ACT Residential Care Facilities (RCFs)will examine whether a maintenance dose of vitamin D3 is effective in improving outcomes such as illness presentations, exacerbations of chronic illness, fractures and death in residents of aged care facilities. The main features of this trial are the assessment of 25(OH)D insufficiency and the commencement of the study drug or a placebo while a control group continues on the usual medications prescribed by thier GPs. After treatment with vitamin D3 or placebo for 12 months, the frequency of unplanned GP visits, hospitalisation, falls and mortality will be assessed.

This study was designed to test the efficacy and social validity of a group program in helping war-exposed young people with posttraumatic stress symptoms. The content of the intervention includes, psychoeducation, techniques to manage intrusive memories, relaxation, and planning for the future. We expect that participants in the intervention condition will report a reduction in posttraumatic stress, depression and anxiety symptoms, as well as improvement in general functioning after receiving the intervention. We also expect the intervention to be socially aceptable to the participants and their parents.

Many Psychostimulant users do not seek treatment for their drug use. Several barriers to treatment have been identified including confidentiality: stigma, socio-demographic factors: employment (particularly full-time employment), gender, and immigrant status, which suggest both physical and cultural barriers to accessing treatment. This study will evaluate the effectiveness of an on-line intervention which uses cognitive behavioural therapy and motivational techniques designed to reduce harmful psychostimulant use.

Although the lungs in children with cystic fibrosis (CF) are essentially normal at birth, airway infection and inflammation may begin within the first few weeks of life. As postnatal lung development, including significant alveolarisation continues during the first 2-3 years of life, this is a vulnerable period where undiagnosed infection and chronic inflammation may lead to irreversible tissue damage and lung disease. Identifying and treating infection (especially with Pseudomonas), in early childhood may prevent significant lung disease, reduce morbidity and improve survival. Early infection is often subclinical and conventional screening methods such as sputum microbiology, chest radiology and lung function, are either not possible or insensitive to detect disease in this age group. Upper airway cultures such as throat swabs or cough suction specimens correlate poorly with lower airway pathogens and the currently available systemic markers of inflammation lack sensitivity. Bronchoaclveolar lavage (BAL) is considered the gold standard for identifying airway infection and inflammation in young children with CF. The association between BAL markers of infection and inflammation and sensitive infant lung function testing such as the multiple breath washout test which determines the lung clearance index has not been studied. This study will investigate early CF lung disease by assessing the relationships between BAL markers of infection/inflammation, the lung clearance index, systemic markers of neutrophil inflammation (S100 proteins) and urinary desmosine. The study will also determine the prevalence of gastro-oesophageal reflux and the relationship between BAL pepsin and airway infection and inflammation.

Recently some neonatal intensive care units have adopted the side lying position for bottle feeding preterm babies. It is thought that there may be a benefit in preterm babies’ bottle feeding in this way. The usual method to give a bottle feed is with a cradle hold. We think that the side lying position more closely resembles the position babies adopt for breastfeeding. Some clinicians have observed that some preterm babies appear to feed better in the side lying position as they seem to be better able to regulate the flow of milk and have been shown to have a more stable heart rate and to be able to breathe better in this feeding position. There is a small amount of evidence to show that the side lying position may have some benefits when bottle feeding preterm infants. However, there are no good studies comparing the effect of the two bottle feeding positions, side lying versus the cradle hold. The aim of this study is to investigate the two bottle feeding positions in a small group of preterm infants. We want to find out if one position is better than the other in terms of a baby’s breathing and heart rate during the feed.

Patients referred to the community rehabilitation programs (CRPs) at the Peter James Centre (PJC) and Wantirna Health (WH) have traditionally been placed on a waiting list and given a triage category, which guides clinicians as to who should be seen first when demand exceeds supply. This study is trialling an alternative model of triage within the orthopaedic team at the PJC CRP in which all patients are seen for a face to face assessment soon after referral, with a subsequent decision on priority and patient management made by the treating clinician. The aim of the trial is to compare the outcomes with the traditional model at WH, and determine whether the new model improves waiting times without negatively impacting on the quality of service received, patient outcomes or staff and patient satisfaction

This study will be a randomised controlled trial to evaluate the clinical benefits of two feeding intervention programs for children with a history of fussy eating, but no major medical history. Baseline assessment will include parent completed questionnaires and on-site feeding and growth assessments. There are two arms of intervention. Arm One is an individual operant conditioning arm. Arm Two involves small group systematic desensitisation therapy. Both arms will involve group parent education sessions regarding nutrition, behaviour management and feeding development. Intervention will be provided in either an intensive format (10 times over the course of a week) or in a weekly format (10 times over 10 weeks) at the discretion of the parent.

This study has been designed to investigate how a high-protein or high-fat preload effect thermogenesis, antropyloroduodenal motility, gut hormones, gastric emptying and appetie. Volunteers are required to visit the department on 3 occasions (6 if they wish to take part in Study 2 as well) approximately 7 days apart. They will be required to injest one of the three preloads on each occassions, and lie supine under a calorimetry hood. Venous blood samples will be taken at set intervals and appetite questionnaire will be answered after a blood sample has been collected. A buffet meal will be presented at 180min and consumed over 30 minutes until comfortably full.

A randomized, placebo-controlled, double-blind, parallel study designed to evaluate the effect of intra-articular knee injection of Ampion (Trademark) in male or female subjects 40 years to 85 years old (inclusive) with symptomatic primary knee osteoarthritis for 6 months preceding screening. The study consists of a 3 week screening period and a 4 day study participation period. Each subject will be randomized to receive a single 10 mL knee injection of one of the following: 1. Ampion(TM) combined with lignocaine/betamethasone suspension 2. Ampion(TM) combined with betamethasone suspension 3. Saline placebo combined with lignocaine/betamethasone suspension