ANZCTR search results

The study examines the efficacy of online CBT for the treatment of adolescent anxiety disorders, with minimal therapist assistance, compared to clinic-based therapy. In turn, the effects of both treatments are compared with a wait list control condition. The role of factors such as working alliance, therapy compliance, and family factors in the prediction of outcome of online CBT will also be examined.

Very little research has examined the potential interventions for the treatment of post-traumatic stress disorder in children following accidental injury. This trial aims to evaluate and compare child only and child plus parent versions of a cognitive-behavioural early intervention. It is hypothesised that children within the treatment conditions will significantly reduce in their post-trauma symptoms compared to those children who do not receive any therapeutic intervention. Furthermore, it is hypothesised that children in the child plus parent condition will reduce in their post-trauma symptoms at a greater rate than those children who receive the intervention without parental assistance. The principal clinical question under investigation is the efficacy of an early, trauma-focused cognitive-behavioural intervention for the treatment of PTSD in children following accidental injury. Specifically, we compare the efficacy of two active treatments (child-focused and family-focused CBT) and a waitlist control (no therapy) to determine which is associated with greater reductions in psychological and health-related outcome measures over time. The primary outcome will be a reduction in trauma symptoms on a diagnostic interview in the active treatments compared to the waitlist control and greater reductions in the family- compared to the child-focused condition. In doing so, this project will also trial a method of stepped screening and assessment to determine those children requiring early intervention for PTSD following accidental injury.

Traditionally, youth anxiety programs have adopted a generic approach where the same treatment program is used regardless of the particular anxiety disorder. The failure to tailor treatment to the specific anxiety disorder may partly explain why a significant proportion of young people fail to respond to such treatments. We propose that a disorder-specific approach will more effective than a generic program in internet-based therapy for youth anxiety. The study involves a randomised controlled trial in which young people with social phobia are randomly assigned to either generic (transdiagnositic) or specific cognitive behaviour therapy, through online delivery, or to a wait list control condition. The impact on anxiety symptoms will then be evaluated over time.

This study examines factors that predict treatment outcome in cognitive behaviour for child and adolescent anxiety disorders. In particular, it will examine the role of family factors (such as parental mental health problems, parent relationship problems, and family environment), and the role of compliance and the quality of the working alliance between the online therapist and family members, in predicting the impact of treatment. The study will have sufficient sample size to enable us to examine whether family factors and working alliance have their impact upon treatment outcome through their influence upon compliance with therapy tasks.

The Victorian Government’s commitment to improving breastfeeding rates includes the development of the Victorian Breastfeeding Action Plan. The Victorian Breastfeeding Research Project (SILC project ) is part of this action plan. The SILC project will assess strategies to increase the maintenance of breastfeeding. The research will consist of a three arm cluster randomised control trial. It will determine if home visiting by a Maternal and Child Health Nurse (MCHN) for women with breastfeeding issues increases the maintenance of breastfeeding, and then if a drop-in centre additional to the home-visiting further enhances breastfeeding rates. The three arms of the trial will consist of a comparison (control) group receiving standard care, a targeted home-visiting group receiving home-based breastfeeding support visits by a MCHN and the third group receiving the targeted home visits plus access to a facilitated local drop-in centre.

The purpose of this study is to research one aspect, the non-therapeutic targeting and tracking functionality, of the Kona Renal Denervation System. The research project is being conducted to gather information about how the system functions when placed in a clinical setting. Information gathered from this research project will be used for the development of the Kona Renal Denervation System.

This project is part of a research program to develop and evaluate an Internet-based education and treatment program for people with chronic pain. This preliminary project examines the efficacy and acceptability of a treatment program to enhance management of pain, anxiety, depression and disability amongst people with chronic pain. We expect that people in either immediate or delayed treatment groups will report similar benefit following the active component of their program.

This is an open-label, fixed regimen clinical study. Enrolled patients were administered low dose metformin (250mg or 500mg) to examine the effect and exposure of metformin in patients with chronic renal impairment. Patients were monitored frequently to ensure metformin concentrations and lactic acid concentrations were not high. The aim of this study is to determine whether metformin can be safely administered to patients with renal impairment.

We have conducted a RCT sub-study within the recruitment phase of a larger project utilising an Australian Cancer Registry to recruit survivors of a haematological study. This sub-study aimed to test the effect of two different patient invitation and reminder letters on participation rates to the study from patients. The first invitation and reminder letters were the standard letters sent by the Cancer Registry. Patients receiving this letter acted as the control arm of the intervention. The second invitation and reminder letters were modified versions of the standard letters incorporating specific changes to wording and formatting which have been identified as potentially increasing suitability, readability and legibility.

Arthralgia (joint pain) and other joint related symptoms are common side effects of taking letrozole (hormone therapy). As such, some patients stop taking their hormone therapy earlier than the recommended 5 years after breast surgery. The purpose of this study is to find out if glucosamine can ease joint pain in patients taking letrozole, and therefore reduce the chance that they will stop their hormone therapy early. Participants (ER and/or PR receptor positive, postmenopausal, early breast cancer) will receive either crystalline glucosamine sulphate (1500mg tablet) or placebo that will be taken concurrently with letrozole and will be followed for a total of 24 months (maximum treatment period of 18 months followed by an off study treatment visit 6 months later). The discontinuation rate of letrozole will be determined at 12 months and 18 months. Off study treatment visit should be 24 months post-randomisation or, if discontinued study treatment prior to 18 months post-randomisation, off study visit should be 6 months post permanent cessation of CGS/placebo.