ANZCTR search results

This study aims to determine if blood flow restriction (BFR) during rehabilitation improves muscle strength in the quadriceps and hamstrings more effectively than standard recovery methods following ACL reconstruction surgery. It is a randomised controlled pilot trial where participants will receive either BFR or a sham treatment in addition to standard rehabilitation. Strength in the operated leg will be measured at 6, 12, and 24 weeks post-surgery using specialised equipment. The results will help decide if a larger study is needed to further explore BFR’s benefits. Participants will be recruited from private practices in Northern Tasmania and will be fully informed about the study and their options. We believe that using BFR during rehabilitation after ACL reconstruction surgery will lead to greater improvements in muscle strength in the quadriceps and hamstrings compared to standard recovery methods. This means that patients who undergo BFR will likely recover more effectively and regain strength in their legs more quickly after surgery.

This is a Phase 1 study to evaluate the effect of food on the PK of SION-719, and the bioequivalence of a solid oral formulation compared to the oral suspension.

The iSISTAQUIT Ngurrajili project aims to determine the best method of implementation for iSISTAQUIT smoking cessation training for health providers to address smoking in Aboriginal and/or Torres Strait Islander pregnant women. It will determine the process of implementation that is sustainable and cost-effective in Aboriginal and mainstream health services in Australia.

The present clinical investigation aims to investigate the safety and feasibility of a novel bioscaffold in patients requiring defect repair and restoration of anatomic contour in non-critical sized, non-load bearing portions of the craniofacial skeleton following routine craniofacial operations. This is a first-in-human pilot study for this bioscaffold. It is hypothesised that there are no serious adverse events associated with the actv-graft bioscaffold.

This study aims to evaluate the impact and effectiveness of a new AR education package used in conjunction with daily INCS/INAH in reducing AR symptomatology and improving quality of life, in comparison to the standard of care education that is currently provided via treating healthcare professionals. Ultimately, it is hoped the results of this study will improve education management of those living with the burden of AR. This flows on to benefit families, carers, the healthcare system and the wider community.

Poor dietary patterns such as a high-calorie, high-fat (HCHF) diet can contribute to insulin resistance (IR), which is a condition where body does not respond to insulin as it should, and eventually lead to type 2 diabetes (T2D). Several human studies have confirmed that even 3-7 days of a HCHF diet impairs glucose metabolism, that is it impairs the ability of the body to remove glucose from the blood stream for energy storage and/or energy production. Our team has recently completed a human study (funded by Diabetes Australia, Ethics No: 2019-014) that showed 7-days of a HCHF diet in 14 healthy individuals led to increased meal-induced insulin concentrations within 3 days, followed by reduced meal-induced blood flow in the smallest capillaries of the muscle, also known as muscle microvascular blood flow after 7 days, compared to pre-intervention. However, the above-mentioned studies focused on saturated fat as their main source of fat. Whether the incorporation of high omega-3 polyunsaturated fats into a HCHF diet may protect against HCHF diet-induced hyperinsulinemia and impairments in skeletal muscle microvascular blood flow in healthy humans is not known and is the aim of the current study. We hypothesise that increasing omega-3 fat content in diet will protects against high fat diet-induced ‘early’ vascular impairments.

This study aims to explore whether consuming eggs in the evening can improve sleep and overall health for perimenopausal women. Perimenopause often leads to sleep disturbances due to hormonal changes, which can impact anxiety, appetite regulation, and overall well-being. Eggs contain nutrients like protein and melatonin that may promote better sleep. The study's primary goal is to determine if evening egg consumption, along with sleep hygiene education, can enhance sleep duration. Secondary aims include reducing perimenopausal symptoms, assessing the acceptability of evening egg consumption, evaluating changes in urinary melatonin, appetite responses and body composition.

This study is a first in human (FIH) clinical trial evaluating a drug called LAVA-1266 in patients with myelodysplastic syndrome (MDS) and relapsed/refractory acute myeloid leukaemia (R/R AML). Who is it for? You may be eligible for this study if you are an adult who has a confirmed diagnosis of CD123 positive R/R AML or intermediate risk, high risk, or extremely high risk MDS. Study details Participants will undergo a 1-month screening period and then receive every 2 weeks (or bi- weekly) intravenous infusions of escalating doses of LAVA-1266 for up to 12 months, or until disease progression, unacceptable toxicity, or withdrawal of consent or other study discontinuation criterion is met. Participants will be asked to provide data on side effects as well as blood and bone marrow samples for outcome assessment. It is hoped that findings from this study help researchers develop a new treatment option for patients with AML and MDS.

This is a retrospective and prospective observational study where data will be collected on participants who have received Remplir™ during a peripheral nerve surgical procedure in a real world setting. This study is aiming to provide data on the safety and performance of Remplir™ in a wide range of peripheral nerve surgical procedures and patients in the real world.

This randomised controlled trial of VR versus traditional care using pharmacological anxiolytics aims to test the hypothesis that immersive VR distraction is non-inferior to drug therapy when used to provide peri-operative anxiolysis for patients admitted for hand surgery