ANZCTR search results

Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most discussed health topics on social media, with an increasing rate of individuals self-diagnosing based on online content. However, some of the content consists of misleading or misrepresentative symptom descriptions, which may contribute to misdiagnosis, overidentification, and unnecessary distress. This study aims to examine the impact of different types of ADHD-related TikTok posts (personal anecdotes vs. awareness campaigns) and the accuracy of symptom descriptions (evidence-based vs. misrepresentative) on participants' perceptions, emotions, and self-diagnosis intentions. It is hypothesised that personal anecdotes will evoke higher intentions to self-diagnose, internalized stigma and emotional engagement, but lower intentions to seek an official diagnosis and perceptions of credibility compared to awareness campaigns. Further, content featuring misrepresentative symptoms is hypothesised to lead to higher intention to self-diagnose, stigma, and stronger emotional responses. Interaction effects are anticipated, with personal anecdotes containing misrepresentative symptoms eliciting the highest intention to self-diagnose, stigma, and emotional response, while awareness campaigns containing evidence-based symptoms are expected to result in the highest intention to seek an official diagnosis and credibility. Given the increasing influence of social media on health perceptions and self-diagnosis behaviors, this study will provide valuable insights into how different types of ADHD-related online content affect individuals' understanding and decision-making. The findings can contribute to discussions on responsible health communication, misinformation, and the potential risks of self-diagnosis based on social media content.

This study is being undertaken to evaluate the safety and clinical effectiveness of the M-Finity Femoral stem with a Medacta Acetabular Cup in primary total hip arthroplasty through a CT-based migration analysis. The purpose of this study is to assess the safety and clinical effectiveness of the M-Finity in a pilot study on a small patient series. This will be achieved by both assessing the adverse events and conducting a stem migration and rotation analyses on patients who are having the M-Finity device.

This study aims to investigate whether laser acupuncture can enhance brain and motor function in healthy adults. Laser acupuncture is a non-invasive technique that applies low-level laser therapy to specific acupuncture points to stimulate physiological responses. This research will compare the effects of real and sham laser acupuncture on corticospinal excitability and sensorimotor function. The findings may help improve our understanding of how laser acupuncture influences the nervous system and whether it has potential applications in rehabilitation or performance enhancement.

This study aims to investigate whether eating mussels as a snack can improve recovery and nutritional status in female endurance athletes. Participants will consume either mussels or an isocaloric portion of nuts five times per week for 12 weeks. We will measure omega-3 index, iron status, vitamin D levels, and post-exercise recovery to compare the effects of the two snacks. We hypothesise that mussel consumption will lead to greater improvements in these health markers compared to nuts. The findings may help support new dietary strategies to enhance athletic recovery using sustainable whole foods.

Young adults have the poorest diet quality out of all age groups, however, are motivated towards climate action. A potential way to improve their diets is to promote healthy and sustainable diets in this group. This study involves the development of a targeted healthy and sustainable nutrition program for young adults, and an assessment of its feasibility. It is expected that the program will have acceptable feasibility i.e. high response rates and low drop out rates.

This study is to investigate the safety, tolerability, and PK of EIK1005 in healthy participants. EIK1005 is a potent and selective inhibitor of WRN, which has been identified as a synthetic lethal target in MSI-H cells. MSI-H is a marker of cancer cells with defective mismatch repair. WRN inhibition (WRNi) acts on MSI-H cells, and thus WRNi is not expected to have an effect on healthy tissue. EIK1005 is noncytotoxic and is been considered has as potential targeted therapy in patients with MSI-H or dMMR solid tumors.

The primary purpose of the study is to assess the safety and tolerability of a single oral dose of EP102 600 or 400 mg self-administered at home by adult participants experiencing moderate-to-severe migraine headache.

The present study aimed to evaluate the impact of the Body Blocks program on early learning educators’ knowledge, attitudes, and teaching practices by conducting a randomised controlled trial, with participants randomised to either an intervention group or waitlist control. We anticipated that participants randomised to the intervention group would report higher educator knowledge and attitudes about body image compared to educators in the waitlist control group, as well as greater confidence and capabilities in promoting positive body image. In addition, we explored the moderating role of demographic variables (i.e., age, years in the profession, socio-economic-status), as well as educators’ own body and functionality appreciation and fat attitudes on our main outcome of interest (i.e., knowledge and awareness).

Temperament-Based Therapy with Support (TBT-S) is an innovative, adjunctive eating disorder treatment that incorporates the neurobiology of eating disorders. Patients and their support person(s) attend a 5 day intensive multi-family therapy program that involves psychoeducation, group activities and meals. This study will investigate both the feasibility and acceptability of the TBT-S program in Victorian mental health services from the experience of the patient, their support person and the clinicians involved in the program. It is hypothesised that TBT-S will be an acceptable and feasible treatment option for patients and their supports.

Binge eating disorder (BED) is the most common eating disorder and is associated with obesity and psychiatric comorbidities. Psilocin taken in combination with talk therapy might be a useful treatment for BED by reducing overall anxiety, anxiety around food, perseveration, and repetitive and intrusive thinking, as well as improving mindfulness and self-compassion. This open-label study will evaluate the safety and efficacy of a novel intravenous (IV, i.e. into the vein) formulation of the psychedelic psilocin (TRP-8803) in 12 people with BED. IV administration of TRP-8803 permits a more rapid start to the psychedelic state compared to psilocin taken orally as a tablet, and allows the administering therapist to control and optimise the dose and if required, rapidly reduce the depth of the psychedelic experience by stopping the infusion (i.e., in case of an adverse effect). Eligible participants will complete two doses of TRP-8803, administered in conjunction with psychotherapy over a treatment period of 6 weeks, and followed up until 12 weeks post second dose. Safety will be assessed. Other indicators of clinical severity will also be explored from baseline through to 12 weeks post second dose.