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This study will evaluate a new model of care which aims to improve the introduction process for new patients coming into the palliaitve care service. Palliative care is based on a philosphy that acknowledges the physical, social, psychological, spiritual and cultural elements which make up the total patient. By introducing a comprehensive multidisciplinary assessment process it is hoped that patients will feel that they have been understood and that their presenting illness is understood within a context of their own value and belief base. As a result of this multidisciplinary assessment clinic the care plan will reflect the domains of care that contribute to 'good palliative care'and that patients and their families will have a solid understanding of what they can expect from a referral to a specialist palliative care service.

Malnutrition is a significant and highly prevalent problem in those undergoing peritoneal dialysis (PD), and has been associated with increased morbidity and mortality. PD patients often experience gastrointestinal symptoms and together with a fluid restricted diet can limit the tolerance to nutritional supplements. The goal of this study is to evaluate the efficacy of provision of a nutritional supplement, given as a liquid (drink) or a food (snack bar) for improving the health outcomes of PD patients who are malnourished.

The Brien Holden Vision Institute (previously known as the Institute for Eye Research) conducted a clinical trial to test commercially-available multifocal contact lenses for their potential to control the progression of myopia in children(IERP2007-009, ACTRN12611001148965). The trial was completed in 2008. Approximately half of the 40 children who participated in trial IERP2007-009 were enrolled in a subsequent myopia control trial at the Brien Holden Vision Institute (IER2008-001, ACTRN12611001141932) in which all participants wore the test product of trial IERP2007-009. This research is based on the hypothesis that the peripheral retina plays a role in controlling the refractive development of the eye as shown in animal experiments (Smith et al. 2007).

This is a pilot study looking into safety of giving bolus of ropivacaine followed by continous infusion for 48 hrs in Transversus Abdominis Plane Block. Safety of this regime will be established by serial blood samples to analyse toal & free ropivacaine concentration , Serail ECG 's looking into QTc interval & patient will be observed for sign & symptoms of Local anaesthetic toxicity

The main aims of the study are to: 1. Determine the feasibility of conducting a 14- week Tai Chi or Yoga program in a residential care setting. 2. Observe and record the modified Tai Chi and Yoga approaches used for older people with different levels of balance ability 3. Determine the feasibility of detecting changes in balance, pain experience, quality of life and incidence of falls in older residents who follow the Yoga/ Tai Chi programs compared to those who receive usual care.

This study will evaluate which ocular measures of alertness are capable of detecting driving impairment during a two hour track driving session. Drivers will be assessed twice: once when rested and once following 30 hours of continuous wakefulness. Additional assessments of reaction time and sustained attention will be undertaken. These findings will help to determine the validity of ocular measures as a tool for fatigue detection, with the aim of reducing sleep-related motor vehicle accidents. In addition, ten professional drivers will be observed carrying out their normal driving duties for 2000km. Assessments will include lane deviation and ocular measures using Optalert. Daily measures of PVT performance and KSS scores will be taken.

This is a randomized, open-label, multicenter, Phase 3 study, comparing the efficacy and safety of eribulin with TPC in subjects with advanced NSCLC and disease progression following at least two prior regimens for advanced disease, which should have included a platinum-based regimen.

The study will be investigating the suspected causes of surgical wound dehiscence and will develop a diagnostic tool to be used in a clinical setting.

Alzheimer’s disease (AD) is the most common form of dementia, currently affecting at least 35 million people worldwide and expected to double every 20 years. The risk of acquiring Alzheimer’s doubles every five years after the age of 65 and may be affected by common alterations in the fat transporter gene (APOE). The brain contains large proportions of fats such as cholesterol and omega-3 fatty acids. APOE plays a crucial role in maintaining healthy fat distribution such as cholesterol and omega-3 fatty acids, as well as brain cell repair and scavenging of toxins. Common alterations in the APOE gene, may directly or indirectly increase DNA damage and accelerate brain aging and degeneration. This disease is currently considered incurable and greatly highlights the need for preventative measures and therapeutic interventions, such as nutritional supplementation, that may improve DNA stability and mental health.

This study aims to determine if immediate exercise therapy can improve health by reducing initial adverse effects during the initial phase of AST and if this provides superior benefits to delayed exercise therapy. Who is it for? You may be eligible to join this study if you are a man with prostate cancer who is about to initiate AST. Trial details. Participants in this trial will be randomly (by chance) allocated to one of two groups. One group will immediately undergo supervised exercise training 3 times per week for 6 months. This involves aerobic (walking/jogging, cycling, rowing), resistance (lifting weights), and impact (hopping, jumping) exercises and then monitored (without training) for a further 6months. The other group will be assigned to usual care for the first 6 months. After this time participants in this group will commence the exercise program for the next 6 months. Participants will have measurements of bone mineral density, body composition, blood markers, blood pressure, arterial stiffness taken at 4 occasions (baseline, 3-, 6-, and 12-months). Participants will also complete tests of their muscle strength, balance and physical function as well as complete a series of questionnaires at these time points.