ANZCTR search results

Sitting is recognised as a new risk factor for developing chronic illnesses that is independent of physical activity. Current knowledge is limited regarding effective strategies for reducing sitting in the workplace. This study will evaluate whether using sit-stand workstations in the office changes office workers’ sitting time at work and outside of work. Sit-stand workstations allow office staff to switch between sitting and standing while they are working at their desks. Participants (n=50) will trial the sit-stand workstations for 4 weeks and complete questionnaires about their sitting time before and during the trial. They will also wear activity monitors which will objectively measure their sitting time at each measurement time point. After the trial, participants will have a debrief session where they will give feedback about the sit-stand workstations.

Anaemia is prevalent among Aboriginal infants under 12 months old. Delayed cord clamping is a simple way to provide extra blood to the newborn baby. Strong evidence from randomized controlled trials has shown its benefits for neonatal health and reducing anaemia in early infancy. The beneficial effects on Aboriginal infants and beyond the first 6 months of life are still unknown. It is clinically important to determine if this simple intervention at birth will impact greatly the health of remote Aboriginal infants with high risk of anaemia due to poor access to nutrition later in infancy. This RCT will enroll 72 Aboriginal pregnant women from remote aboriginal communities who will give birth at 36-42 weeks gestation by uncomplicated NVD or CS. They will be randomly assigned to either receive the interventional delayed cord clamping until the cord stops pulsating or up to 3 minutes with baby held below level of placenta or vaginal introitus or the standard care immediate cord clamping soon after birth under 1 minute. The primary research question is whether haemoglobin level at discharge is greatest in babies after delayed cord clamping.

In this study, we hope to examine tDCS effects on global arousal and attention levels. Combining evidence gathered from animal models, psychological models, pharmaceutical research, and neurostimulatory research - we hope not only to better elucidate the overall arousal/attention correlation, but also to determine if noninvasive brain-modulation can produce effects comparable to certain drug classes.

A 2011 multicentre randomized control trial, undertaken by Aujesky et al, has supported recent changes to European and American Guidelines, and provides convincing evidence that the outpatient management of low-risk pulmonary embolism (PE), is non-inferior to standard inpatient management. EDPED is a comparative cost analysis (randomised control feasability study) between outpatient and delayed outpatient management of low risk PE diagnosed in the emergency department (ED). This study aims primarily to quantify the savings to the Health Department (cost per patient and cost per institution), and qualify patient satisfaction as a result of early discharge from ED. We hope to identify potential areas where health resources may be better directed in the management of low-risk PE. Secondary outcomes will address safety issues of managing PE in the Outpatient Setting (HITH). Patients who are discharged directly from ED (the intervention group) will be closely monitored for complications of their PE / venous thromboembolism or anticoagulation by HITH until their INRs have been stabilized. They will all receive a Respiratory Outpatient appointment 1 week after discharge from ED. Patients who are admitted to Respiratory Medicine from ED will be discharged to HITH in the conventional way (the control group). EDPED will examine primary and secondary outcomes within 90 days of patient arrival to ED.

The project seeks to measure oxygen consumption by precision addition of oxygen to the mixed expired gas until the mixed expired pO2 equals the inspired pO2

Bacterial Vaginosis (BV) is very common clinical condition with prevalence rates between 10 and 30 % of women in the reproductive age group. While in some cases BV is asymptomatic, in many women BV produces annoying symptoms (vaginal discharge, offensive smell). BV may also interfer with successful implantation of an embryo during IVF treatment, as these bacteria may be introduced from the vagina into the uterus at the time of the embryo transfer, causing inflammation of the uterine lining (endometrium). BV has been linked with a reduction in implantation rates in IVF and an increase risk of miscarriage. Therefore effective long term treatment/ prevention of BV in an IVF setting is important. The aim of this study is to determine if the oral administration of a probiotic can result in vaginal colonization and a subsequent reduction in reoccurance of BV infection after antibiotic (tinidazole) treatment.

To see if the broader lateral shoulder of the CPT stem affords more rotational stability than that recorded for other polished tapered stems.

The primary aim of this study will be to conduct a small trial to test the effectiveness of a GAD-specific program with a group of children suffering from GAD, by comparing a treatment group with a wait-list control group. It is hypothesised that children in the active treatment condition, will demonstrate significantly greater reductions from pre-treatment to post-treatment in primary GAD diagnostic status, self and parent-reported anxiety, overall global functioning.

Endoscopic retrograde cholangiopancreatoscopy (ERCP) is a procedure that can assist in the treatment and diagnosis of liver disease as well as gallstone disease. Like all medical procedures, ERCP is associated with complications specifically infalmmation of the pancreas (pancreatitis). Pancreatitis is often associated with more difficult procedures that take longer than normal to complete. In these situations special techniques may be used to successfully complete the procedure, such as directly cutting into the drainage tube (bile duct)from the liver - this is called a needle knife cutting technique. This study looks at whether the use of this needle knife cutting technique may prevent or reduce the risk of pancreatitis complications if performed at an earlier stage.

The purose of this study is to understand how well Oxycodone in combination with tocopheryl phosphate mix (TPM), is absorbed through the skin and into the bloodstream, with the use of a patch.