ANZCTR search results

The aim of this research project is to create partnerships with Indigenous local community agencies and three local high schools to increase the physical activity levels, educational interests and goals, and life skills of their Indigenous students. Additionally, this will provide University of Sydney preservice physical education teachers with a sociocultural teaching experience that increases and deepens their competence and knowledge of Indigenous youth, their current health, physical inactivity levels and educational goals.

The study involves double blinded randomised controlled trial, the surgeon is blinded to which local anaesthetic is used and the assessor is also blinded to which agent has been used. Pudendal nerve block is performed by the colorectal surgeon prior to preceeding to perform open haemorrhoidectomy

This trial has two aims: 1. To determine the characteristics of children who have poorly controlled asthma despite optimal management. 2. Whether using an electronic monitoring device (Smart-inhaler) which includes a reminder function and which can be used to provide feedback on adherenve improves adherence with preventive medication.

Approximately 50% of preterm children born very early have problems at school. Difficulty remembering things, using something technically known as “working memory”, contributes to these school problems. Working memory is the ability to temporarily store information for everyday activities. It is critical for learning information and developing basic academic skills. This study aims to investigate if an adaptive working memory training program, known as Cogmed, can improve school performance in very preterm children at 7 years of age. It will also be the first study to incorporate advanced neuroimaging techniques in a randomised controlled trial of Cogmed, and will be essential for determining and monitoring the neural changes that occur as a result of adaptive working memory training.

This study is observing changes which occur to bone density and structure, muscle mass, and glucose metabolism (the way that the body converts sugars to energy), after stroke. We are investigating how these outcomes are influenced by physical activity after stroke. This information will be used in future designs of rehabilitation programs aimed at improving stroke patients' health and recovery.

This RCT examined the effectiveness and safety of herbal medicine in conjunction with lifestyle changes, for overweight women with polycystic ovary syndrome (PCOS). PCOS is a common disorder with 11-21% prevalence in the Australian and other populations(1). PCOS is associated with short and long term health consequences including significantly increased risks for diabetes, cardiovascular disease and cancer. Up to 75% of women with PCOS have underlying metabolic disease(3) and women with PCOS have increased risks for infertility, pregnancy and neonatal complications, hyperlipidaemia, sleep apnoea, anxiety and depression(1). The progression of disease is exacerbated by increased body weight and improved by weight loss (1). The evidence based guidelines for the management of women with PCOS, commissioned by the National Health and Medical Research Council indicates that lifestyle intervention including diet and exercise, is first line treatment for women with PCOS (1), The strength of evidence however is limited by high attrition in RCTs and clinical uptake remains impeded by the lack of evidence for optimal dietary and exercise practices. In addition physical and psycho-social barriers are often observed in overweight women, particularly in those with established obesity(1). Many women use complementary medicines (CMs) (4-5). This study investigated one of the CMs, naturopathy in combination with lifestyle intervention for improved menstrual regularity, and other outcomes. Naturopathy was defined as a new herbal medicine regime including five herbal extracts. Herbal medicine is chemically complex and may improve several aspects of PCOS, however the current evidence base is limited (6). This randomized controlled trial will examine the effectiveness and safety of combined herbal medicine and lifestyle intervention in overweight women with PCOS. 1. AAPCOS. Evidence based guidelines for the assessment and management of polycystic ovary syndrome. March 2011, https://www.nhmrc.gov.au/guidelines-publications/ext2 2. ESHRE. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertility and Sterility. 2004;81(1):19-25. 3. Hart R, Norman R. Polycystic ovarian syndrome – prognosis and outcomes. Best practice & research Clinical obstetrics & gynaecology. 2006;20(5):751-78. 4. Williamson M, Tudball J, Toms M, Garden F, Grunseit A. Information use and needs of complementary medicines users. National Prescribing Service. Sydney: Department of Health and Ageing, NSW Government; 2008. 5. .Arentz, S., Smith, C.A., Abbott, J.A., Bensoussan, A. A survey of the use of complementary medicine by Australian women with PCOS. BMC Complementary and Alternative Medicine 2014 14 (1) p.472 6. Zhang J, Li T, Zhou L, Tang L, Xu L, Wu T, Chinese herbal medicine for sub-fertile women with polycystic ovarian syndrome. Cochrane Database of Systematic Reviews 2010 (9)

DAILIES TOTAL1 RegisteredTradeMark by CIBA VISION is one of the new silicone hydrogel daily disposable lenses recently released into the contact lens market. This study intends to provide more information on the clinical performance of DAILIES TOTAL1 RegisteredTradeMark in terms of ocular health, vision and subjective comfort. It will allow for comparisons to previous and future contact lens related studies in the hope that it can contribute to further understanding on what causes cotnact lens related discomfort and dryness. The hypothesis of this study is that the ocular responses and subjective comfort ratings will be dissimilar in participants wearing DAILIES TOTAL1 RegisteredTradeMark and other lens types.

Progressive Supranuclear Palsy (PSP) is an idiopathic, rapidly progressive neurodegenerative disease for which there is currently no diagnostic test or any disease modifying treatment. It is caused by an accumulation of mictotubule associated tau protein in the basal ganglia, midbrain and cortical regions. There is selective loss of inhibitory interneurones and corticocortical projections leading to frontal atrophy which may correlate with the motor and cognitive disabilities. Transcranial Magnetic Stimulation is capable of inducing action potentials in cortical neurones, and provides the capacity to measure cortical neuronal excitabilityand interneuronal function. Preliminary data shows this may be a method for measuring neuronal function in PSP, which may enable its use as a biomarker. The intention of this study is to determine if these measure ments are able to distinguish PSP from other parkinsonian syndromes with similar clinical features, and if these measurements correlate with advancing clinical features over time.

The aim of this study is to find out if people following a distal radal fracture recover better if they receive a progressive exercise program. Our hypothesis is that a progressive exercise program imiplemented during the rehabilitation phase following a distal radius fracture in addition to advice will achieve better recovery of upper limb activity and functional activities than advice alone.

Clariti TradeMark 1day by Sauflon Pharmaceuticals is one of the new silicone hydrogel daily disposable lenses recently released into the contact lens market. This study intends to provide more information on the clinical performance of Clariti TradeMark 1 Day in terms of ocular health, vision and subjective comfort. It will allow for comparisons to previous and future contact lens related studies in the hope that it can contribute to further understanding on what causes contact lens related discomfort and dryness. The hypothesis of this study is that the ocular responses and subjective comfort ratings will be dissimilar in participants wearing Clariti TradeMark 1 Day and other lens types.