ANZCTR search results

This study evaluates the effects of adding Bodyflow therapy to the standard of care treatment after patients underwent a surgical procedure for total knee replacement (TKR). The Bodyflow treatment will consist of an in-hospital component, as well as a self-administered component after the patient has been discharged. The effect of the treatment on the duration of the post-operative hospital stay will be the primary objective, while its effects on peripheral tissue oedema and patient’s pain scores are evaluated as secondary objectives.

This study involves 3 drugs called MK-0906A, Proscar and Tamsulosin intended for treatment of benign prostate hyperplasia (BPH). BPH is a very common medical condition in most men above 50 years of age and is characterised by enlarged prostate gland resulting in difficulty in urination. This study is testing and comparing the safety, tolerability and pharmacokinetics (level of drug in your blood) of a single dose of MK-0906A, Tamsulosin and Proscar in different treatment combinations and sequence.

The trial is investigating how, and to what extent an injection of stem cells, obtained from your own fat tissue, reduces pain & inflammation, repairs structural damage, affects mobility, and affects quality of life in knee osteoarthritis.

There are currently very few criteria to guide as to which youth would benefit most from using more advanced diabetes technologies, for example continuous subcutaneous insulin infusion (CSII). The lack of robust selection criteria means that intermittently, patients who may not benefit are commenced on CSII and subsequently encounter disappointment and regimen disruption if they elect to switch back to injected insulin. The ability to reliably predict lower self-care, as extrapolates to technology usage, would be helpful when advising an individual regarding their regimen. The purpose of this study is to see if this questionnaire can accurately predict which individuals will be most likely to use technology so that they gain the most benefit from it for their diabetes control. We wish to explore its ability to predict use of the two most commonly used technologies presently - continuous glucose monitoring (CGM) and CSII. Studies have shown that individuals get a clinically significant improvement in their HbA1c from usage of CGM when they use it 70% of the time, which equates to 5 days in any week. From CSII, most clinical benefit is gained when users enter 5 or more blood glucose measurements in their pump per day. Our hypothesis is that our questionnaire will predict individuals who will/will not display this usage of their device. Usage of CGM will be assessed after three months, as usage at this point has previously been shown in studies to be predictive of medium to long term usage. Likewise, usage of CSII at six months after commencement has been shown to be indicative of medium term usage.

The purpose of this study is to find out whether adult patients admitted to the Intensive Care Unit with septic shock who are given hydrocortisone compared to placebo (a dummy solution), will have an improved rate of survival 90 days later. Septic shock is the result of an infection, which triggers a complex response by the body (the inflammatory response) that causes a decrease in blood pressure and subsequently one or more organ systems to fail when blood supply to these organs is reduced. This may result in poor recovery and death. About a quarter of the people who suffer septic shock that is not rapidly reversed, will die. When patients are admitted to Intensive Care with sepsis and/or septic shock they receive a number of therapies. These include fluids given through a drip, antibiotics, drugs to boost your blood pressure and other organ systems. In addition to these therapies, steroids (hydrocortisone) are sometimes administered. Whether steroids are useful or not in the treatment of severe infections has been studied for more than 50 years. Previous research has suggested that the use of low dose steroid may have shortterm benefits in improving the circulation. However, there is no agreement amongst doctors around the world about whether treatment with or without low dose steroids improves the overall recovery and survival in patients with septic shock. This study would allow doctors to make informed decisions about whether the addition of low dose steroid therapy is better for patients with septic shock in intensive care. The study will include 3800 intensive care patients who have septic shock. Each enrolled patient will be randomised to receive either Hydrocortisone 200mg or placebo daily for 7 days as a continuous intravenous infusion while in intensive care. The patient will be followed for 90 days. If the patient is discharged prior to 90 days a telephone call will be made for the followup information. At six months the patient will be contacted again for completion of a quality of life questionnaire.

In Australia Pulmozyme is licensed for use in CF with mild/moderate lung function impairment. All CF patients are eligible for an initial one-month trial, but continued funding after one month dependent on a 10% improvement in FEV1. The purpose of this one month trial of Pulmozyme is to provide information for each individual patient as to whether they benefit more with Pulmozyme before or Pulmozyme after their physiotherapy technique. Following a period of optimization of their therapy, the patients undergo 2 two-week periods: Pulmozyme given before physiotherapy, and saline nebulized after physiotherapy with the second two weeks in the reverse direction. The other half of the subjects are randomly allocated to the reverse order of interventions. Outcomes include lung function, quality of life, sputum, weight and exercise testing.

Comparison of group, individual and home based treatments for speech and language delays and disorders in young children.

The purpose of this study is to assess the safety and tolerability of BMS-929075 in healthy subjects.

This study will compare novel pulmonary rehabilitation (community nurse telephone-delivered) with rehabilitation. Community nurses will be trained in the ‘CENTREd’ Model of Self-Management Support. There is a focus on walking for exercise and other health-behaviours identified in the ‘SNAPPS’ Health-Management Framework according to current guidelines (Smoking cessation, Nutrition, Alcohol consumption, Physical activity, Psychosocial well-being, Symptom management). The study addresses the continuum of care for people with COPD from referral from the Royal Hobart Hospital (RHH)/private practitioner until discharge from out-patient pulmonary rehabilitation.

The number of Australians with dementia is increasing and so is the frequency of people with dementia presenting to general medical practice. This project aims to improve the care of people with suspected cognitive impairment in general practice. We have conducted interviews with 30 GPs from urban and rural settings in Victoria, Australia to determine their clinical behaviours and knowledge with respect to the detection, diagnosis and management of cognitive impairment and dementia and their perceived barriers to implementing evidence-based recommendations. A national survey is currently being conducted to further explore GPs’ current clinical practice in this area. Using this information we have designed a targeted theory-based intervention to implement these evidence-based recommendations into clinical practice once cognitive impairment is suspected by the GP. We will conduct a cluster randomised controlled trial to test the effect of this targeted intervention and establish if the intervention is effective in increasing the number of cognitively impaired patients in whom the GP undertakes the recommendations to formally diagnose or exclude dementia. Automated search strategies will be developed to extract evidence-based recommendations from de-identified patient electronic medical files including completion of a Mini-Mental State Examination and a screen for co-morbid depression using a validated scale. General practices (n= 126) will be randomised to receive either the targeted theory-based intervention, or to a control group receiving access to the evidence-based clinical practice guideline alone. This project will contribute to the body of knowledge about how to bring about practice change. The outcomes of the study have the potential to improve the detection and diagnosis of people with suspected dementia in primary care.