ANZCTR search results

Intravenous crytsalloid fluids are one of the mainstays of in-hospital patient treatment with fluid intervention being ubiquitous for surgical and critical care patients. Cognitive changes such as a perceived difficulty in abstract thinking or mental arithmetic has been reported in subjects exposed to a commonly prescribed crystalloid solution - Normal Saline (0.9%). The postulated mechanism for the altered cognition is unclear but could be a result of NS 0.9% induced hyperchloraemia or NS 0.9% induced acidaemia (normal anion gap metabolic acidosis) that frequently occurs following saline administration. No study has attempted to formally investigate cognitive changes after the administration of saline or other commonly administered crystalloid solutions. Plasmalyte solution is a frequently used crystalloid solution with similiar properties to saline. However it is a more physiological and balanced crystalloid solution compared to saline as it has a significantly lower chloride concentration and physiochemical profile similar to normal plasma. Study hypothesis: Is normal saline associated with greater cognitive changes than Plasmalyte in healthy volunteers?

Study C2011-0301 is the first study in man for SAN-300. SAN-300 is being developed for the treatment of rheumatoid arthritis. SAN-300 will be administered intravenously in 9 cohorts and subcutaneously in 3 cohorts. Approximately 66 healthy volunteers and approximately 8 patients with active rheumatoid arthritis will be enrolled to receive a single dose of SAN-300 or Placebo. Participation in the study is approximately 1 month, including dosing and follow-up visits. Subjects will receive the dose of study drug and remain in the clinic for 24 hours. There are 5 follow up visits conducted over 1 month.

This project investigates the efficacy of a novel internet-based insomnia treatment program (SHUTi) as a prevention tool for Major Depressive Disorder.

The main aims of this research project are to compare the effects of routine therapy, considered as the combination of stretching, strengthening, casting and the application of botox, to the proposed therapy consisting only of stretching, strengthening and myofascial trigger point therapy. The effects of weekly myofascial trigger point therapy alongside stretching and strengthening will be measured in a group of children aged between 4 and 12 years with muscle spasticity. It is proposed that the study will be small due to limited resources, but the intention is to publish the results for further research in this area. We hypothesise that myofascial trigger point therapy when applied to spastic muscles is successful at maintaining or increasing muscle length.

The general aim of this research is to investigate whether continuous tri-axial accelerometry is a usfull tool for the qunatification, and characterisation of movements during sleep in a clinical diagnosis setting. This research targets: - Movements as a consequence of movement disorders (Such as Periodic Leg Movements During Sleep), - Movements as a consequence of arousals during the night - Movements as a conqequence of respiratory events during the night 50 adults attending The Princel Charles Hospital Sleep Service for a Diagnostic Polysomnogram (sleep study) will be recruited. In addition to the standard physiological channels recorded in a sleep study, Multiple accelerometers will be strategically placed on each subject (ankle and big toe, wrist and middle finger and central thorax). Data will be analysed to determine whether: - The amplitude of movements observed using accelerometry predict cortical arousal - Continuous triaxial accelerometry may be used to automatically classify sleep from wake more accurately than commercial actigraphs - Multisite accelerometry allows primary limb movements to be distinguished from gross body movements as a consequence of arousal or other events - Indices of movement events correlate with qualtiy of life measures

Patients with complex lower limb trauma experience severe pain. Opioids and inflammation activate glia which may increase the severity of pain experienced. Minocycline acts via inhibiting Toll Like Receptor 4 and may reduce pain severity if given early. This and drugs with similar effects at TLR4 receptors appear to work well in animal models of severe pain. Minocycline may also reduce opioid tolerance and opioid side effects particularly respiratory depression.

The aim of this study is to evaluate the efficacy of an internet guided education program for OCD and a guided bibliotherapy education program for OCD compared to waitlist control. It is hypothesized that: 1. Participants in the Internet Group will obtain results at least equivalent to those obtained in the recent pilot study (ACTRN12610000687099), and superior to those in the Waitlist Group. 2. Participants in the Bibliotherapy Group will obtain improvements significantly greater than those in the Waitlist Group. 3. There will be no difference in outcome between the two active groups 4. Both active treatment groups will find the treatment acceptable.

Patient matched instruments use pre-operative MRI and radiographs to produced custom instruments for total knee replacement surgery. We aim to verify the accuracy of these blocks using standard intra-operative navigation with computer assisted surgery, and post-operatively with xray assessment.

The aim of this study is to investigate the feasibility of implementing low intensity interventions within a university health service. The objectives are to: 1. Increase the identification and early intervention of students who are experiencing high levels of distress. 2. Evaluate the effectiveness of low intensity intervention on student wellbeing (vs. screening and treatment information alone); 3. Evaluate uptake, retention, and perceived relevance and utility of LI-CBTs within a health service context.

Chronic diseases such as chronic obstructive pulmonary disease (COPD) are characterised by chronic, underlying organ dysfunction with intermittent acute worsening of the disease that often results in hospital admission. There is good evidence to suggest that regular monitoring of certain physiological and symptom related variables in the homes of patients with COPD may be beneficial. If deterioration can be detected early and appropriate interventions instituted, it may be possible to achieve improved patient outcomes and a reduction in the use of healthcare resources. The technology to remotely monitor relevant physiological variables in the home situation is now available and there is some evidence that these devices are robust and capable of being reliably used by patients with COPD. Randomised controlled studies in this field are needed to establish the efficacy of RPM and to better define the role of this new technology in managing these conditions. We designed a randomised controlled trial to determine whether remotely monitoring symptoms, medication usage and physiological variables over 12 months was feasible in patients with moderate-severe COPD and whether this intervention could improve quality of life or reduce healthcare use.