ANZCTR search results

This study investigates the use of metformin in Australian Aboriginal and Torres Strait Islander patients with type 2 diabetes. The aim of this study is to compare the pharmacokinetics of metformin in Australian Aboriginal and non-Aboriginal Australians patients. It involves obtaining a medical history of the patient and asking patients about their metformin formulation, dose, dosing times and their compliance to the medication.

The aim is to determine whether 4 fingerprick BGLs routinely performed at nominal times of 0700, 1200, 1700 (these three timeslots are just before meals) and 2100 hours accurately assess the efficacy and safety of basal bolus insulin in hospitalized patients.

People living in residential aged care facilities (RACF) are amongst the most vulnerable Australians. Their acute healthcare needs are great yet we do not know whether the current system of providing much of this care in hospitals meets their interests or those of the broader community. This trial will test a new model of caring for people in RACF, to determine whether it can reduce hospital utilisation and improve quality of life.

The current research aims to determine whether changing the treatment paradigm from a drug to a non-drug (i.e psychological) approach will result in improved outcomes for those with a unipolar non-melancholic depression. By altering the primary treatment approach, we hypothesise that more positive outcomes are likely to occur.

The primary purpose of the study is to investigate telmisartan as a novel therapy for patients with abdominal aortic aneurysms. We hypothesize that telmisartan will reduce AAA growth.

The trial aims to assess whether in women undergoing simple gynaecological laparoscopy, the Proseal (TM) airway device reduces post-operative pain and/or nausea and vomiting. We will also assess whether the device reduces sore throat or hoarse voice.

The purpose of this project is to explore whether a clinician-guided treatment program can help to reduce anxiety symptoms in a population of mature adults (aged 60-75), when administered over the internet. A secondary purpose is to determine how acceptable people find this form of treatment. The study will inform how services can best improve future treatment programs for mature adults with anxiety.

The purpose of this project is to explore the efficacy of a clinician-guided treatment program for symptoms of depression in older adults (aged 60-75), administered over the internet in a Ramdomised Controlled Trial. A secondary purpose is to determine the acceptability of the treatment protocol and materials to older adults with symptoms of depression. A tertiary purpose of this project is to explore the efficacy of a self-guided version of the program, with participants from the Waitlist Control Group.

Currently, patients who are suspected of having obstructive sleep apnea (OSA) need to be seen by a sleep specialist and undergo a full sleep study in a laboratory to confirm the diagnosis. A full sleep study involves monitoring of brain waves, eye and chin muscle movements to determine different stages of sleep, breathing patterns, oxygen levels, heart rate and leg movements. Waiting lists to see a specialist and have a laboratory sleep study can often be long, even up to 6-12 months in some centres. To address this problem, increasing numbers of simplified sleep recording devices designed to be used in the patients’ own home are being developed, and have a smaller number of channels recording only breathing patterns and/or oxygen levels overnight, without recording of brain waves to determine stages of sleep. It is currently unclear whether patients who undergo simplified sleep study recordings to test for OSA have treatment results (for example, in the degree of improvement in their symptoms) compared to patients who undergo full sleep studies. In this study, patients referred to a sleep specialist for investigation of possible OSA will be randomly assigned to one of three groups for diagnosis: (1) an overnight sleep study with full monitoring of brain waves, eye and chin muscle movements, breathing patterns, oxygen levels, heart rate and leg movements; (2) an overnight sleep study with monitoring of only breathing patterns, oxygen levels, and heart rate or (3) an overnight sleep study with monitoring of only oxygen levels. The aim of the study is see whether patients who receive treatment from a sleep specialist on the basis of a simplified sleep study recording will do as well (in terms of improvement in symptoms and ability to perform usual daily activities) as patients who have had a full sleep study after 3 months of follow-up.

This study examines the potential of a web-based tool to help cancer doctors explain survival time to their patients with advanced cancer who wish to receive information about their likely survival time. Who is it for? You may be eligible for this study if you have been diagnosed with incurable cancer, you wish to receive information on your prognosis and you are able and willing to complete a written study questionnaire about your attitudes to the web-based tool anfd the information you received. The study will also collect information from medical oncologists and other health professionals involved in the care of the cancer patients, along with family members and carers of the patient in order to build an overall picture of the usefulness of the tool. The overall duration of the study is 6 months but if you participate you are only required to complete one questionnaire that takes less than 10 minutes to complete. Trial details: The aim of this study is to find out if patients and their family members find the information provided by the web-based tool helpful and if cancer doctors find using the web-based tool helpful. We will also be providing information on likely survival time to other doctors and nurses helping to care for these patients to find out if they find receiving this sort of information on their patients helpful. The overall duration of the study will be for 6 months and each participating cancer patients will be given 2 weeks to complete and return a written questionnaire.