ANZCTR search results

The current study will investigate the feasibility and effectiveness of a combined treatment approach for primary school aged children who are suffering from traumatic stress and sleep disturbance after experiencing a traumatic event. The 10-session treatment utilises both Cognitive Behaviour Therapy for Insomnia (CBT-i) and Trauma-Focused Cognitive Behaviour Therapy (TF-CBT) that are recommended evidence-based treatments for sleep and posttraumatic stress, respectively. Outcome measures will be assessed at pre-, during- and post-treatment, and at a 3-month follow-up. Primary outcomes are posttraumatic stress (diagnosis, good end-state achievement, severity reduction) and sleep (onset, duration, awakenings, efficiency). Important secondary outcomes include behavioural sleep problems, quality of life, and feasibility (i.e., ease of delivery). It is hypothesised that this approach will be feasible, and we predict that most clients will achieve good end state functioning in terms of posttraumatic stress symptoms and sleep disturbance.

PRSE’s naturally occur in plant derived foods and beverages and holds great potential for enhancing human health. However, further research is required to understand the broad-spectrum of effects of PRSE’s by assessing its potential short and long-term benefits to general well-being. This study is a 6 month double-blinded randomised controlled cross over trial. Participants will receive either the control sample (placebo) or the PRSE sample for a duration of 3 months, followed by the reversal of conditions for the subsequent 3 months. The nutritional intervention is to be completed in the participants own setting (i.e. home/work). This study aims to investigate the prebiotic effects of PRSE, as well as the effects on inflammation and key blood biomarkers, including HbA1c, C-reactive protein, and triglycerides/omega-3 status. The study will also explore the influence of PRSE on general mood and well-being.

The purpose of this study is to determine whether it is feasible for Early Career Pharmacists (ECPs) in Australia to take part in an online peer support program. The program is inspired by Hand-N-Hand Peer Support, an initiative originally created for medical personnel in 2020. In the future, it is hoped that more in-depth studies will be conducted to trial the efficacy of such a program as well. If deemed feasible and effective, an aim is for the pharmacy profession to adapt a similar model to boost morale and maintain employee retention.

This project involves consumption of two mixtures of herbs and spices by overweight and obese subjects for a period of six months. Body composition, body weight, blood pressure and blood lipid levels of the subjects were measured throughout the study (baseline, 3 months and at 6 months) to investigate the effects of the mixtures on these health outcomes.

This study is trialing a digitally enabled model of care to improve glycaemic outcomes in people with type 2 diabetes. The digital tools will enable remote monitoring of diabetes related measures, provide contextual feedback through SMS, easier communication with healthcare professionals and earlier identification of individuals that need enhanced care. It is hypothesized that digital tools for remote monitoring that provide contextual feedback to patients and smart monitoring by healthcare professionals will improve self-management leading to improved glycaemic profile and efficient diabetes care. We will use the REMODeL primarily to: A1: examine glycaemic outcomes in people with type 2 diabetes (T2DM) at 6 months. Assess the impact of REMODeL model of T2DM care pathway on: A2: glycaemic control at 12 months and blood pressure and lipids A3: diabetes distress, patient self-management A4: did-not-attend rates and earlier discharge to primary care. A5: attendance rates at diabetes specialist clinic outpatients, emergency department and hospital admissions A6: healthcare delivery cost and the cost-effectiveness of this model of care

The purpose of this study is to assess the effect of adding channels to scleral contact lenses upon corneal tissue swelling and tear flow behind the contact lens in young healthy adults during short-term lens wear (6 hours). The null hypothesis is that the incorporation of scleral lens channels will have no significant effect upon the primary outcome measures.

This project will investigate the effects of exercise with blood flow restriction on sensitivity to pain and subsequent physical performance. It is hypothesised that the application of blood flow restriction during low volume resistance exercise will reduce pain perceptions whilst maintaining subsequent physical performance. The data will inform best practice for treating athletes suffering from pain due to musculoskeletal injuries in a sporting context.

Safewards is a model that was developed in the United Kingdom for use in mental health inpatient services. The model is based on training staff, and giving staff the resources, to implement 10 psycho-social interventions that allow staff to reduce resident distress, agitation and anger. By doing so, the interventions reduce escalation of conflict between staff and residents, and in reducing conflict, there is a reduction in the use of restrictive practices, such as the use of physical restraint. The study we are undertaking is testing if the Safewards model is effective in residential aged care.

Children with cerebral palsy (CP) participate less in physical activity and have high levels of sedentary behaviour compared to children without CP. In this research we will conduct a mixed methods randomised controlled trial called Active Start Active Future with families who want to support their child’s physical activity participation and consider their own physical activity. We are aiming to determine whether Active Start Active Future is effective in changing the amount of physical activity, physical activity participation and reduce sedentary time for the child at home, in the community, preschools and schools. We will ask parents about their understanding and beliefs around physical activity and sedentary behaviour for their child with CP, explore the parents’ own physical activity behaviours, and explore ways they can support their child be more active. Our aim is to recruit 40 children aged 3-7 years with CP in Gross Motor Function Classification System (GMFCS) levels II-V inclusive of children who need gait aids for mobility or do not walk. We will conduct a physical activity behaviour-change intervention once a week, for 8 weeks face-to-face (with telehealth opportunities if requested). Our trial is innovative because it intervenes earlier in the development of sedentary behaviour and will be one of the first studies to include children who cannot walk independently. The intervention is grounded in evidence-based theories of health behaviour change, individualised for each family, and will be delivered by a paediatric physiotherapist or occupational therapist. Anticipated benefits include gaining a greater understanding of physical activity participation in young children with CP and mechanisms to help change behaviours.

We intend to measure the effectiveness of psychedelic assisted medicines (methylene dioxy methamphetamine - MDMA) when combined with talking therapy; for the treatment of Post Traumatic Stress Disorder in real world patient groups We will test how effective MDMA is for PTSD and treat patients who have had limited benefits with existing treatments for these hard to treat conditions.