ANZCTR search results

This project is a prospective registry which is designed to evaluate the contemporary patterns of care for patients who are admitted to hospital with an acute coronary syndrome (ACS) in Australia and New Zealand. More than 400 centres that treat ACS patients will participate and the researchers expect to enrol approximately 4,000 patients over a 2 week period. The main objective of the registry is to provide a greater understanding of the management and health outcomes of patients across the full breadth of hospitals in both countries. Information on the clinical characteristics, the in-hospital investigations and management patterns will be collected. This will be compared to guidelines for recommended practice. These data will inform future strategies to improve ACS care within Australia and New Zealand.

Samll pilot cross over study comparing two differen tmean arterial pressures in patient having cardiac surgery

Background Asthma is a huge social and economic burden on our community. Acute exacerbations of asthma are linked with worse lung outcomes for children. In school aged children a risk for acute exacerbations include viral infections, which occur mainly in winter, and allergy. A drug called omalizumab may help prevent acute exacerbations by damping the allergy response. Aim We want to see if omalizumab will decrease the number of children with asthma having an acute exacerbation.

This study will assess whether cereals can improve mineral bioavailability in postmenopausal women.

This RCT compares the efficacy of a 2 session enhanced BMI (Quik Fix) compared to assessment/information (AI/F) only control, among young people with cannabis/alcohol use and high levels of psychological distress. It was hypothesized that Quik Fix would result in significantly larger reductions on the primary outcome variables of psychological distress and alcohol/cannabis use. It was also hypothesized that Quik Fix would result in significantly larger improvements on the secondary outcome variables of motivation to change alcohol/drug use, the severity of mental health symptoms and alcohol/cannabis use and functioning.

To cross-validate two new peripheral aberrometers: the EyeMapper and the Hartmann-Shack (HS) Scanner with dilated and undilated pupils.

This study aims ot assess the effectiveness of ketamine as an pain reliever when administered into the nasal passages in doses that do not produce sedation or anaesthesia in a group of adult emergency department patients coming to hospital with moderate to severe pain. We hypothesise that ketamine will reduce pain effectively without significant sedation at the proposed dose. A positive result may allow ketamine to be considered as an alternative pain reliever for acute pain in the emergency department that could be adminsitered through the nose and reduce the need for insertion of intravenous catheters in some patients suffering from moderate to severe pain.

Chiropractic care is currently being provided by chiropractic Interns, under supervision, to residents of Palmerston Farm a therapeutic community, with this service having been provided to date for over 4 years. This study will measure the outcomes of this service in terms of students’ perception of the service and residents’ satisfaction with care and treatment outcomes. All eligible participants (interns and residents of Palmerston Farm) will be provided an Information Sheet concerning the project and will be required to provide written informed consent prior to participation in the study. Volunteers for the treatment part of the study will undergo a standard case history and physical examination, including a relevant orthopaedic evaluation and consent to procedures. Patients that do not demonstrate any contradictions to chiropractic care (manual and manipulative therapy) will then enter the study and undergo chiropractic care, as required. Treatment will consist of conservative care such as manual and manipulative therapy, soft tissue therapy, exercise prescription and rehabilitation programmes, applied based on the presentation of the patient. Treatment will be provided on a weekly basis to those residents (patients) that volunteer for the study, over a 6-week period. Hence, each participating patient will typically receive 6 treatments over a 6-week period. Participants in the control group will anonymously complete PSQ and R-36 forms. Data will be collected at baseline and at the end of each participant course of treatment, or after six visits whichever is sooner, using the stated outcome measures; PSQ and RAND-36. Data will be collected from the participating chiropractic Interns at the end of their outreach programme at Palmerston Farm; using a modified SPSLE. The questionnaires used for this data collection will be provided online using the so called 'SurveyMonkey' tool. No identifiable risks or problems are anticipated to arise as a result of the implementation of this study, beyond the usual issues that may be encountered when offering this care in the context of a substance misuse recovery facility.

This randomised, double-blind and standardised clinical trials investigated the clinical effectiveness of pulsed Nd:YAG Laser induction of pulpal analgesia compared with 5% EMLA The current study strengthens other reports of the clinical effectiveness of Nd:YAG Laser induction of pulpal analgesia in a carefully planned and standardised, blinded controlling manner. Further studies are however needed to define the optimal Laser parameters, the reversibility of the analgesic effect and the follow-up induced changes on tooth morphology and the pulp for Laser-induced pulpal analgesia. Of particular significance is that Laser-induced pulpal analgesia is effective, minimally invasiveness and therefore, has significant implications world-wide particularly in underdeveloped countries. anaesthetic cream.

Traumatic brain injury (TBI) is the leading cause of death and disability amongst adolescents and young adults. The incidence of TBI in Australia is 300 per 100,000, of which 20% are classified moderate to severe. The prevalence of TBI in the community is high because of the survival rate and the demographic groups at most risk are adolescents and young adults. Although a minority of people who sustain a moderate to severe TBI can expect to make a full recovery, over 75% of victims never return to full independence and function. In contrast to the vast literature on neuropsychological impairments following TBI, surprisingly little information is known about the effect of the brain injury on gait. My recent systematic review found the key biomechanical abnormalities of gait were yet to be determined. Further, the key physical impairments contributing to mobility limitations have not been established. Several studies have suggested balance may be primarily responsible. Although balance, spasticity, contracture, muscle weakness and inco-ordination may all contribute to mobility limitations, my research has identified that balance and strength deficits are most prevalent, but the primary cause of mobility limitations was muscle weakness. Physiotherapy is routinely provided to treat the physical impairments that contribute to mobility limitations in order to optimize rehabilitation outcomes for people with TBI. Balance training and muscle strengthening programs are widely used. Strong evidence exists indicating balance training improves balance disorders and strength training improves muscle weakness in neurological populations, yet little evidence exists supporting the impact of either intervention on mobility limitations. Further, a recent international symposium on research priorities for TBI highlighted the urgent need for rehabilitative therapy research as virtually no level 1 evidence exists. The primary aim of this research program is to investigate whether ballistic strength training is more effective than usual carer for improving mobility following TBI. The research program constitutes a randomised controlled trial (RCT) comparing ballistic strength training and usual care for improving mobility following TBI.