ANZCTR search results

This study will investigate whether providing cognitive behaviour therapy provides better reduction of postconcussive syndrome symptoms than education about postconcussive syndrome in patients following mild traumatic brain injury. Patients will be randomly allocate patients with postconcussive syndrome to either (a) cognitive behavior therapy, or (b) education, and assessed for postconcussive symptoms following treatment.

A randomised controlled trial (RCT) will be used to evaluate the effectiveness of the BO program; an internet-based CBT program for BN. Participants will be randomly assigned to one of three conditions; (1) BO with therapist assistance (BO-TA); (2) BO automated self help (BO-ASH); or (3) a wait-list control (WLC) group. Participants in the BO-TA condition will be allocated an online therapist (who will be a fully or provisionally registered psychologist) who will email them once per week and whom they can email as often as they wish. Participants in the BO-ASH condition will be sent a weekly automated email reminding them to complete the modules and encouraging them to think about important points from each module. Participants in the WLC condition will have access to the BO-ASH condition after three months. Participants randomised to the intervention conditions (BO-TA and BO-ASH) will complete online assessments at pre, post- and 3-month follow-up. Participants randomised to the waitlist control condition will complete online assessments at pre and post waitlist, as well as post and 3- month follow-up BO. This study is a repeated measures design with three time points. We will employ multi-level modelling to allow for the comparison of the two BO programs and waitlist control condition in terms of changes in clinical diagnosis, BN specific symptomatology, general psychological functioning and quality of life, drop-out, and program engagement while controlling for and testing for any important participant variables such as age, gender and education. In addition, pre-, post- and follow-up variables will be subjected to correlational and multiple regression analyses to determine significant correlates of treatment adherence and attrition and potential predictors and discriminators of successful intervention outcome.

The incidence of bacteria in the urine after radical prostatectomy when patients still have their catheters is not known. How qucikly the bacteria clears after the catheter is removed is also not known. Presence of bacteria is a risk for infection which can increase patient morbidity. We want to investigate the rate of bacteria in the urine before and after catheter removal and the incidence of symptomatic urinary tract infection

This project aims to determine if 12 weeks (three times per week) of high intensity intermittent exercise (HIIE) and green tea consumption leads to significant fat loss and improvements in metabolic markers for diabetes and cardiovascular disease in overweight men. We have shown that HIIE leads to significant fat loss and increase in insulin sensitivity in women and now want to demonstrate this effect in men. The ability of HIIE to increase catecholamline secretion may be the reason why this form of exercise combined with green tea consumption results in more fat loss compared to exercise such as walking and jogging. We hypothesize that exposure to 12 weeks of HIIE and green tea will result in: - significant subcutaneous and visceral fat loss - significant increases in insulin sensitivity - significant increases in aerobic and anaerobic fitness We also hypothesize that: - greater hepatic fat loss will occur when green tea is consumed with HIIE

Due to the results of previous studies both in vivo and in vitro, we hypothesised that curcumin may decrease paraproteinemia and bone turnover in MGUS and indolent myeloma patients. A pilot study conducted by us showed a reduction in paraprotein levels and the uNTX bone turnover marker in a select group of MGUS patients. This trial is a continuation of the pilot study and we aim to prove that curcumin may act to prevent the progression of MGUS to active myeloma.

This study is designed to evaluate the pharmacokinetics, safety and tolerability EMA401 in healthy elderly subjects (56 years and over) after two single oral doses of EMA401 Sodium Salt administered on the same day with a 10 hour interval between doses, for a total daily dose of 200 mg.

This study will involve taking a venous sample from the same venepuncture uses as a part of their normal routine treatment and an additional two capillary finger stick samples from all participants. Samples collected are tested on both the medical device and the laboratory reference.

The purpose of the trial is to conduct a prospective randomised controlled trial of Versajet hydrosurgery debridement (removal of necrotic/ non-viable tissue) of burns versus conventional tangential excisional debridement in paediatric patients. To date no trial has compared excisional debridement with Versajet hydrosurgery in paediatric burns patients. Our hypotheses is that 1.Versajet debridement leads to increased dermal preservation and accuracy of debridement 2.Versajet debridement is faster than conventional tangential excision in areas that are difficult to debride such as the hands, feet or perineum. 3.Graft healing time is equivalent following Versajet or classical blade debridement 4.Versajet debridement leads to improved outcomes post skin grafting such as hypertrophic scarring and contracture 5.Bacterial load is lower in the Versajet group following debridement

Obesity and asthma are two of the most common conditions affecting Australian children and adolescents. Epidemiological studies have indicated a link exists between obesity and asthma. Obesity is associated with chronic systemic inflammation. Given that asthma is characterised by chronic inflammation of the airways, we hypothesise that obesity is amplifying airway inflammation and impacting adversely on clinical asthma outcomes in children and adolescents.

This study aims to assess the effects of testosterone on endothelial progenitor cells numbers and function in men. By understanding the effects of testosterone on endothelial progenitor cells, we may be able to better understand the potential role that male sex hormones may play in maintaining heart and blood vessel function in men. This research may ultimately lead to new treatments to help with heart and blood vessel repair. To Public: This study aims to assess the effect of male sex hormone on the male stem cells. By understanding the effect we may be able to use male sex hormone to maintain human heart and blood vessel function in men.