ANZCTR search results

Suntinib is a drug with variable PK and toxicity profile that impacts upon its clinical use. This study will be targeted to patients receiving Sunitinib for the treatment of advanced renal cell cancer or GIST. Patients will have functional hepatic imaging and blood taken for pharmacogenomic studies of drug handling and drug target enzyme genes. During treatment patients will be monitored for response and toxicity and have bloods taken for steady state PK. We will then try to correlate PK, toxicity and response with liver imaging and genomic parameters in an attempt to develop doing nomograms.

The aim of this study is to determine the efficacy of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids. It is hypothesised that 1. Paracetamol prescribed in addition to regular opioids will not improve analgesia compared to opioids alone in patients with pain from advanced cancer, and; 2. combining n-of-1 trials from multiple subjects provides a feasible variation on randomised controlled trials (RCTs) in palliative care (PC) to produce population evidence of high quality.

The purpose of this study is to determine if the use of the word ‘pain’ when asking for pain scores in the post-anaesthesia review after caesarean section results in higher scores than if the word ‘comfort’ is used instead.

The aim of the study is to determine if adequate local analgesia can be obtained to undertake dental extractions of permanent teeth in the upper jaw among children by buccal administration of local analgesia only without the need for palatal administration of local analgesia.

The consumption of rye foods has been shown to improve some markers of bowel and metabolic health in humans. However, the effects of rye foods on the activity and numbers of bacteria of the large bowel, which are increasingly being shown to be important mediators of gut health and health more broadly, are poorly understood. It is the primary objective of this study to determine whether the consumption of a rye bread selectively stimulates the growth of the bacteria Bifidobacteria and Lactobacilli in the large bowel of humans.

The purpose of this project is to study how ventilators (breathing machines) support babies. We are investigating how we use the ventilator with the aim of better matching the babies' natural breathing patterns. The ventilator can vary the pressure it uses to adjust to your baby’s breathing. We set a maximum inflation pressure limit for how high it can go. Previous experience suggests that this having this limit set higher means babies can get a mixture of higher and lower pressures which may irritate some babies. Setting the limit lower means the ventilation pressures are more even. If the ventilator senses that the pressure limit is too low it will sound an alarm.

The purpose of this project is to study how ventilators (breathing machines) support babies. We are investigating how we use the ventilator with the aim of better matching the babies' natural breathing patterns. The flow rate affects the speed at which air and oxygen come from the ventilator and affects how quickly your baby’s lungs are filled. Previous experience suggests that higher flow rates can fill the lungs faster but may irritate some babies. Lower flow rates fill your baby’s lungs more slowly and may mean that your baby needs longer to breathe completely in and out. If the ventilator senses that the flow is too low it will sound an alarm

The purpose of this project is to study how ventilators (breathing machines) support babies. We are investigating how we use the ventilator with the aim of better matching the babies' natural breathing patterns. The backup rate is the speed at which the ventilator works if your baby does not breathe fast enough. Previous experience has suggests that higher backup rates do not give your baby as much chance to breathe for themselves. Slower backup rates give your baby more change to breathe naturally, but when the ventilator takes over it works more slowly.

This study aims to determine the efficacy of arthritis relief plus for knee osteoarthritis pain. THis is a mix of 20 natural therapies. The design is randomised and double blind for 3 months followed by a one month wash out in 140 patients with significant knee pain due to arthritis.

This study is aiming to determine if playing the Nintendo Wii is potentially a useful addition to a therapy program in adults with an acquired brain injury