ANZCTR search results

The GLAMA study is a pilot program to evaluate the provision of leadership training to Year 10 girls so they can implement physical activities during Physical Education with Year 7 students and then independently during lunchtimes. The activities have been designed to provide opportunities for thinking, team work and physical activity to promote positive attitudes to physical activity.

No research data supports decisions regarding the impact of increasing supervisor to student ratios on learner performance, to increase system capacity (Lekkas L, et al 2007, Ladyshewsky,1995). Our study will determine the best model of education to be utilised when clinical educators are supervising multiple students. This will then allow for studies to effectively evaluate the typical one-to-one clinical educator to student teaching ratio with higher student to educator, supplying essential data with which to evaluate the potential for capacity growth associated with a shift in the design of clinical educator and student models.

Surfactant replacement is the mainstay in prevention and therapy of respiratory distress syndrome (RDS) in preterm neonates. Early treatment with surfactant reduces mortality, and incidence of chronic lung disease (CLD) and air leaks in preterm infants at risk of RDS. Current therapy consists of instilling a liquid bolus of surfactant into the trachea through an endotracheal tube, followed by mechanical ventilation of variable duration. This treatment actually requires the patient to be admitted to a level III care nursery and a risk of ventilator induced lung injury. We propose a new approach to surfactant treatment for moderately preterm infants born with respiratory distress, as well as for more mature infants born in a non-tertiary hospital setting. By using nebulised surfactant, we propose that babies will have their mild-moderate respiratory disease treated without the need for invasive ventilation or transport to a tertiary neonatal unit.

The purpose of this study is to investigate the amount of movement, if any, of a metal backed partial knee replacement using x-rays taken at follow-up visits. A computer program will be used to analyse the x-rays to measure if the replacement has moved and how much it has moved since it was put in or since the previous follow-up visit.

The main goal of asthma treatment is to achieve good asthma control. This cluster randomised trial will test the effectiveness of two brief asthma management interventions, delivered by GPs, for improving asthma control in primary care. The effect of both interventions separately and their interaction will be tested by multiple linear regression.

The aim of this clinical study is to determine the safety and effectiveness of the cemented Total Hip System (E2 stem/P2 cup). This will be done by collecting information and data on measured outcomes on the Total Hip System, using RSA method to provide early results on the implant. The intended use of this implant is for patients with degenerative joint disease who require a primary total hip replacement.

Clinically significant levels of emotional distress and behavioural avoidance are quite frequent after a traumatic brain injury. Interventions with a traumatic brain injured (TBI) population have demonstrated general benefits of group programmes in addressing some of these issues but to date, programs have utilised cognitive behavioural therapy (CBT) as a treatment protocol. At this time, there appears to be no published studies using acceptance and commitment therapy (ACT) with a TBI population. Acceptance and Commitment Therapy (ACT) is one of the ‘third wave’ of behavioural therapies. It aims to change our relationship with internal experiences (thoughts, feelings, memories and physical sensations) so they no longer act as barriers to valued behaviour. The aim of the study is to implement a psychological treatment program to improve psychologically functioning following a traumatic brain injury utilising Acceptance and Commitment Therapy (ACT). With improved psychological functioning it is anticipated that participants will increase their participation in rehabilitation and movement towards a more valued life. The study will be a randomised controlled group treatment programme. Clients of the brain injury rehabilitation unit demonstrating clinically significantly levels of psychological distress will be randomly allocated to either the treatment group or the control group (consisting of an active control based on Befriending protocol). It is anticipated that the treatment will be offered over a two year period. The intervention will consist of six by two hour group treatment sessions offered weekly at the brain injury unit with a one month follow up session. Content of the sessions will be based on ACT theory including identification of values, defusing techniques, self as context and mindfulness. Testing will be undertaken prior to the commencement of treatment and after the one month follow up with brief measures being undertaken weekly at the beginning and conclusion of each treatment sessions relating to motivation and capacity to complete homework tasks. Demographic information will be collected and elicited from the existing brain injury unit database. Participants on the wait list control will be given the opportunity to participate in the intervention after the second outcome measures are undertaken. De-identified data form the outcome measures will be analysed statistically for changes pre and post intervention. De-identified demographic and medical information will provide descriptive data about the participants. Attendance at other therapy appointments in the brain injury unit will be reviewed to measure level of participation.

The objective of the study is to determine the acute neurocognitive effects of a dose of Panax quinquefolius in healthy middle aged volunteers. The Cognitive Drug Research (CDR) computerized assessment battery will be used to evaluate effects of Ginseng on attention, working memory and secondary memory. Mood will also be assessed. Several paper and pencil questionnaires will also be completed which are designed to evaluate state and trait feelings of anxiety and depression and also to asses any symptomatology associated with the extract. Furthermore the neurophysiological effects will be measured using high spatial resolution electrical brain recordings measured by the Steady State Probe Topography technique (SSPT)

Gabapentin is a drug that is officially used to treat chronic pain. This study looks at whether it can help with the more acute pain from having broken bones in the wrist or ankle repaired with screws and plates. This is very painful for a relatively short period and if we find that gabapentin can help with this pain then this could become part of normal treatment.

This study looks at the effectiveness of valproate in combination with interferon alpha in treating relapsed, recurrent or progressive neuroblastoma in children. Who is it for? You can join this study if you are 21 years or younger with relapsed or refractory (stubborn and resistant to treatment) neuroblastoma and you have no other effective treatment options available. Participants will receive treatment with a specific combination of valproic acid and interferon. Valproic acid is an anticonvulsant that has been shown to have an anti-cancer effect. New data has shown that the combination of valproic acid and interferon has an anit-neuroblastoma effect. The study aims to assess the effectiveness of this treatment, and monitor toxicity and side effects.