ANZCTR search results

This study aims to demonstrate that an immunotherapy made from a patient's own blood cells, (known as Rheumavax) can safely modify (reduce or desensitize) the body’s immune response to a specific rheumatoid arthritis antigen.

This project involves the evaluation via a randomised control trial (RCT) of an on-road Assisted Ride Program for Victoria based on best practice rider training and education for newly licensed motorcycle riders. Qualified and experienced motorcycle rider training instructors will provide coaching and feedback to newly licensed rider participants on their riding skills and behaviours over the course of a 4 hour supervised on-road ride. The anticipated benefits of the project are safer on-road riding by participants, and reduced engagement in risk taking behaviours and crash involvement. If the program produces road safety benefits for participants, then it may be introduced on a state-wide basis to reduce road trauma among this vulnerable group of road users.

Investigation of the brain activation patterns of 4 acupoints ( LR14, CV14 HT7 and LR8) found to be highly significant in the treatment of unipolar depression in a double blind randomised controlled trial and an additional acupoint KI3 considered useful in associated anxiety and fatigue in depression.

While it is known that patients with Parkinson’s disease (PD) lose more weight and have a higher risk of decreased bone mineral density and increased inflammation when compared with age-matched controls, and deep brain stimuation of the subthalamic nucleus (STN-DBS surgery) in PD is followed by weight gain, there has been limited research that has investigated specific factors that impact upon nutritional status in PD. There has also been limited research in regards to the measurement of nutritional status in Parkinson’s disease. The overall aim of this project is to determine the influence of motor and non-motor symptoms and inflammation on nutritional status in people with Parkinson’s disease and how deep-brain stimulation modifies the severity of symptoms and inflammation and therefore their impact on nutritional status. The specific aims of the proposed project are to: *Identify potential factors influencing nutritional status changes in Parkinson’s disease. *Evaluate the effectiveness of available subjective and objective tools in the assessment of nutritional status in Parkinson’s disease. *Provide evidence to inform effective nutritional interventions aiming to address the decline in nutritional status associated with Parkinson’s disease.

An experimental study to investigate the brain effects of laser acupuncture on 4 acupoints found to be highly significant in a pilot study on the use of laser acupuncture in mild to moderate depression- using functional magnetic resonance imaging.

The aim of the research is to evaluate the effectiveness of the following treatments for lifelong Premature Ejaculation (PE): (a) Priligy alone, (b) Cognitive-Behavioural Therapy (CBT) alone, and (b) Combined Priligy and CBT. The effectiveness of the interventions will be measured by pre and post treatment measures including intra-vaginal ejaculation latency time (IELT), distress, satisfaction with treatment, sexual satisfaction, relationship satisfaction, self-esteem, self confidence, masculinity, and partner sexual dysfunction. It is expected that all three treatments will be effective, but that the combination therapy will be more effective than Priligy alone or CBT alone in improving all of the above variables.

The purpose of this study is to compare hair drug analysis with urine and blood drug analysis which is currently used for investigating allegations of drug facilitated sexual assault (DFSA). Our hypothesis is that hair drug analysis will detect additional drugs than those detected in urine and blood samples. In addition, we hope to document drugs involved in suspicions of DFSA in the South Australian population, identify which drugs may have improved detection with hair toxicology and document time frames for drug detection in different biological specimens.

This study has been designed to investigate how the extent of hydrolysated protein effects gut motility, gut hormones and appetite sensations. Volunteers are required to visit the clinic on 3 occassions no less than 3 days apart. Visits will last for approximately 5 hours. A long flexible tube will be inserted through an anaesthetised nostril and passed through into the small intestine to monitor stomach and small intestinal contractions. Through this tube, a protein solution will be infused into the small intestine over a 90 minute period. Blood samples will be taken (through a cannula, which is a long flexible tube inserted into a vein) and questionnaires on appetite sensations will be completed every 15 minutes. At the end of the 90 minute solution infusion, a buffet meal will be provided. This meal will be consumed over 30 minutes until the volunteer is confortably full.

Neutropenia is a complex haematological disorder charactarised by a abnormally low level of neutrophils in the blood. F-627 is being developed to treat neutropenia especially for the management of neutropenia in patients with cancer. F-627 is being developed by Generon (Shanghai) Corporation to provide additional benefits to cancer patients by shortening the duration and lessening the severity of neutropenia after chemotherapy. The purpose of this study is to researech the safety of the use of F-627 in Healthy Male Volunteers. There will be no benefits from participating in this trial, Patients will receive only one dose of study drug.

Modern anaesthesia incorporates the use of short-acting opioids such as remifentanil. Lately, there has been emerging evidence in the literature that some opioids might influence postoperative sleep quality for up to many months. We aim to compare sleep quality after exposure to 2 opioids regularly used in the clinical routine at Royal Perth Hospital.