ANZCTR search results

Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung disease in which airways become thick and inflamed, making it hard to breathe. Cells in the airways make more mucus than usual, which tends to obstruct the airways, contributing to cough and difficulty getting air in and out of the lungs. Chronic inflammation present in COPD is a complex response of the immune system that may occur for a long period of time and cause undesirable consequences in the body tissues and organs. Inflammation may not only damage the lungs but also affect one’s daily living activities. Neutrophils are a type of white blood cells found in your lungs, that if increased, may cause lung damage. SCH 527123 is a new investigational drug that is intended to block the movement of neutrophils into the airways. Treatment with SCH 527123 may decrease the number of neutrophils in the airways which may lead to the improvement of lung function, COPD symptoms, COPD exacerbations and quality of life. Reducing the number of neutrophils in the airways may also prevent or delay the progression of disease as measured by the deterioration in lung function. The primary purpose of this study is to evaluate the safety and effectiveness of SCH 527123 in subjects with COPD.

An experimental study to investigate the afferent nerves involved in laser acupuncture at HT7 in healthy subjects : using functional MRI.

Recruitment will be through the Black Dog Institute, UNSW. Due to the twice weekly intervention and then weekly intervention in the second month, only metropolitan participants will be accepted. The study is expected to continue until at least 50 subjects are recruited or until June 2010 ,whichever is first.

This study looks the effectiveness of a web-based toolkit for young women, explaining how to reduce the risks of cervical cancer. You can join this study if you are a woman aged 19-26 years, have access to the internet and are considering a GP visit to discuss cervical cancer prevention. Trial details Participants visiting their GP will be divided into two groups. One group will be provided with an online ‘decision tool’ prior to the consultation. The other group will have a standard consultation only. The web-based toolkit will be a one-stop source of information for the latest information about cervical cancer, and will also provide feedback on consultation length, HPV knowledge, etc. Women will ideally learn to access the tool before their Pap test every two years. The aim is see whether the toolkit is effective in increasing the proportion of young women adequately informed about HPV without increasing the consultation time. The preparation of patients before the consultation is an important model that could be transferable to other aspects of general practice.

A very strong predictor for developing diabetes is having diabetes during pregnancy. In the vast majority of cases, pregnancy diabetes resolves after the delivery of the baby, but these women are then at high risk of subsequently developing type 2 diabetes. This project aims to reduce this risk. Women who have developed diabetes during pregnancy will be invited to take part. A lifestyle modification program will be developed and evaluated for these women so that their risk of progressing to diabetes is reduced. Reduced risk will be assessed by monitoring clinical and behavioural outcomes of participants in the lifestyle program before and after completion (particularly any reduction in diabetes risk, weight and central body obesity, and changes in quality of life) and by comparing these with another group receiving usual care at the same time.

A prospective randomized trial of the method of follow-up: cases registered in a national registry who were 3-months post-stroke receive the survey by mail or telephone. Data included collection of stroke and re-hospitalisation rates, and health-related quality of life. Response rates, time to response, and completeness of data were compared. Factors potentially associated with the outcome were explored.

An experimental study to compare the brain effects of needle versus laser acupuncture on one acupoint (LR8) in healthy subjects using functional MRI.

The study investigated the pharmacokinetics of phenoxodiol given as an intravenous bolus and a continuous intravenous infusion in a first-in-human study, to patients with advanced cancer.

The study compares the feasibility of two different consent mechanisms for parental participation in data linkage of their infants’ vaccination and health records to evaluate vaccine safety. When their infant is 6 weeks of age (prior to their 2 month vaccinations) parents will be sent an information sheet about the study. In the opt-in arm, parents will be asked to signal willingness to participate in data linkage by returning a signed reply form (or can phone or email). In the opt-out arm, all parents will be included unless they indicate an unwillingness to participate by returning a signed reply form (or can phone or email). When their infant is 10 weeks of age (after their 2 month vaccinations), every household will be called and a parent will be asked to participate in a 20 minute telephone interview, in order to elicit attitudes, and knowledge about, data linkage, consent preferences, and their baby’s vaccination status. This study will examine the following null hypotheses: Primary hypothesis That an opt-in or opt-out method of consent will result in an equal proportion of parents consenting to participate in a study of vaccine safety data linkage. Secondary hypotheses Neither consent option will result in parental participation >90%. That there are no differences in parental demographics between those who choose to participate in data linkage and those who do not.