ANZCTR search results

This study is a randomised study that will investigate the safety and effacy of intravenous Zoledronic Acid and standard care compared to Standard Care in children and young adolescents, diagnosed with Perthes Disease. The hypothesis is that 12 months of intravenous zoledronic acid will retard femoral head collapse resulting in: improved femoral head sphericity at 24 months and improved hip function and reduced hip pain at 24 months

Patients with relapsed ALL will receive 18 days of oral Everolimus (RAD001) in combination with HyperCVAD therapy. The first 6 patients will receive 2.5mg dose of RAD001. The data of these 6 will be reviewed to assess whether or not subsequent patients can progress to 5mg dose of RAD001, or the trial should be closed.

The primary aim of this study is to determine the efficacy of EPA-rich fish oil in the amelioration of chronic work stress. A secondary aim is to contribute to the understanding of the causal relationship between dietary fatty acids and psychological stress. The primary hypothesis is that that EPA-rich fish oil will significantly reduce chronic work stress in comparison to a placebo over a 16 week period.

There is much controversy in the literature around the identification and treatment of malnutrition. There has been little previous work done in this field. Recent local research has quantified potential misidentification of categories of malnutrition which is relevant as all malnourished individuals are currently treated as if they are starving. This is inappropriate as some wasting conditions are not reversed by refeeding. This project will survey members of the Dietitians Association of Australia to provide information on professional opinions and current dietetic practice with reference to malnutrition as a whole, and to different categories of wasting syndrome. The perspective of the dietetic profession in Australia is vital to the production of well rounded, and locally relevant, research.

Primary purpose is to assess the effect of the hospital based walk-in clinic on hospital Emergency Department workload

The purpose of this study is to evaluate the safety and potential effectiveness of CCX140-B in subjects with type 2 diabetes mellitus.

The purpose of this research study is to compare the rate of healing and your perception of pain associated with the treatment of your skin graft donor site. The donor site is the wound left behind when a skin graft has been taken. It is frequently a very uncomfortable wound which usually heals by itself in 10-14 days. Two different types of dressing are being studied. One dressing is currently used typically for donor site care in burn patients on the Burns Unit at the Royal Adelaide Hospital (Duoderm®). This dressing is approved by the Therapeutic Goods Administration for sale and use in Australia. AWBAT-D™ is approved by the Federal Drugs Administration for use and sale in the United States, but in Australia can only be used currently as part of a clinical trial (like this one). The decision regarding which dressing you will receive will be 'random'. If you require two separate donor sites, both materials will be used (one on each site.

Aim: To conduct a prospective trial in a cohort of elderly people to discover the prevalence of dehydration and any association with Omega 3 fatty acid deficiency. This will be followed by a pilot clinical trial aiming to test if 3 month nutritional supplementation with Omega 3 fatty acid may improve thirst sensation, voluntary fluid intake and improve quality of life in comparison with elderly on placebo control. Hypothesis We hypothesise that, there is a positive correlation between prevalence of dehydration and omega 3 fatty acid deficiency in the elderly and supplementation with omega 3 fatty acid will reduce the occurrence of dehydration and improve Quality of life Factors that predispose elderly to dehydration 1. Changes to kidney function and insufficient sensation of thirst. 2. Hormonal changes; normal /increased production of vasopressin, increased response to osmotic stimulation and decreased nocturnal secretions. Atrial natriuretic peptide (ANP) increases secretions with increased stimulation, decreased renin activity and aldosterone production. 3. Neurological impairments altering the hypothalamus and pituitary gland, which affect sensation of thirst. 4. Medication (for example, diuretics and laxatives). 5. Chronic illness, communication issues cognitive difficulties and limited mobility. 6. Not drinking enough water to avoid occurrence of incontinence. 7. Fuid loss due to diarrhoea or vomiting and not compensating for loss. Outcome Improved thirst sensation, voluntary fluid intake and improve quality of life in elderly subjects.

The LoDoCo VRIC study aims to investigate the effect of low dose colchicine on inflammatory markers and coronary artery disease as measured by a surrogate marker, brachial artery flow mediated dilation in a stable coronary artery disease population.

The standard clinical advice for individuals who suffer from recurrent headaches is that ‘the best way to prevent headaches is to avoid the triggers’. There is a plausible argument that such advice may be counter to the interests of headache suffers as it could lead to increased sensitisation and decreased tolerance of headache triggers and therefore more headaches. Research results suggest that it should be possible to increase individual’s tolerance of headache triggers through prolonged exposure for desensitisation or providing exposure as an opportunity to practice coping with headache triggers. The proposed study seeks to compare a psychological treatment that advocates avoidance of headache triggers, with a coping approach that uses exposure to triggers (supported by relaxation and cognitive techniques) except where this is not possible or would seem inappropriate. It is predicted that exposure will increase tolerance to headache triggers and lead to fewer headaches in the long term, whereas avoidance may at best provide short term relief. The study results will have important implications for our understanding of how headache disorders can be more effectively managed in the future.